Clinical Evaluation of Glycolic Acid Chemical Peeling in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled, Split-Face Comparative Study

Background: Although various treatment options are available for the management of melasma, still it is challenging disorder to treat. Apart from topical therapies, newer modalities like laser toning and chemical peeling are being explored to manage this notorious dermatosis. To evaluate and compare the efficacy and side effects of laser toning versus 50% glycolic acid peel in the management of melasma.Methods: A split face comparative study was done in 30 female patients with melasma. Over the right half of patient’s face laser toning was done whereas other half was treated with 50% glycolic acid peel. 4 such sessions were given at an interval of 15 days. Response to treatment was assessed using melasma area and severity index (MASI) score.Results: Baseline mean MASI score on right and left half of patient’s face was 7.85±3.34 and 6.25±1.56 respectively. After completion of 4 treatment sessions, it was reduced to 4.23±1.45 and 3.71±1.10 respectively with statistically insignificant difference between two halves (p=0.08). Recurrence rate of melasma was higher (46.66%) with laser toning in comparison to glycolic acid peel (26.6% patients).Conclusions: Glycolic acid peel and laser toning were comparable in terms of outcome with laser toning showing slightly better results. In comparison to peels recurrence rate and complications like hypopigmentation in Asian patients were higher with laser toning.

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Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study

International Journal of Nanomedicine ◽

10.2147/ijn.s301597 ◽

2021 ◽

Vol Volume 16 ◽

pp. 4251-4276

Author(s):

Heba F Salem ◽

Rasha M Kharshoum ◽

Sara M Awad ◽

Mai Ahmed Mostafa ◽

Heba A Abou-Taleb

Keyword(s):

Comparative Study ◽

Clinical Evaluation ◽

Acne Vulgaris ◽

Retinyl Palmitate ◽

Split Face

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Clinical Evaluation of Roxithromycin: A Double-Blind, Placebo-Controlled and Crossover Trial in Patients with Acne Vulgaris

The Journal of Dermatology ◽

10.1111/j.1346-8138.2004.tb00496.x ◽

2004 ◽

Vol 31 (1) ◽

pp. 6-9 ◽

Cited By ~ 8

Author(s):

Ayten Ferahbas ◽

Serap Utas ◽

Deniz Aykol ◽

Murat Borlu ◽

Umit Uksal

Keyword(s):

Clinical Evaluation ◽

Crossover Trial ◽

Acne Vulgaris ◽

Double Blind ◽

Double Blind Placebo

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Persistent Effects of Adapalene Gel After Chemical Peeling with Glycolic Acid in Patients with Acne Vulgaris

The Open Dermatology Journal ◽

10.2174/1874372220130815004 ◽

2013 ◽

Vol 7 (1) ◽

pp. 42-46 ◽

Cited By ~ 2

Author(s):

Mikiko Uede ◽

Chikako Kaminaka ◽

Nozomi Yonei ◽

Fukumi Furukawa ◽

Yuki Yamamoto

Keyword(s):

Glycolic Acid ◽

Acne Vulgaris ◽

Inflammatory Lesion ◽

Treatment Method ◽

Double Blind ◽

The Third ◽

Chemical Peeling ◽

The Face ◽

Acne Treatment ◽

Skin Function

We investigated the usefulness of adapalene gel as maintenance therapy following chemical peeling with glycolic acid in patients with acne vulgaris. The study period was 14 weeks. The subjects were 23 patients with mild to moderate acne vulgaris (1 male, 22 females). After chemical peeling (CP) of the face was performed 3 times at 2-week intervals, adapalene was applied for 6 weeks using a randomized, double-blind half-side method. On the day of observation, dermatologists examined dermal findings, and measurement was conducted using instruments to analyze the physiological skin function. After the third session of CP was completed, both the inflammatory and non-inflammatory lesion counts significantly decreased. Subsequently, on the adapalene-treated side there were no change in the inflammatory and non-inflammatory lesion counts after the CP 3 times, but on placebo-treated side, there significant increase in the inflammatory and non inflammatory lesion counts. Concerning the results of measurement with instruments, the sebum capacity significantly decreased after the third session of CP. Subsequently, there were no changes after the 6-week application of adapalene or a placebo. These results suggest that post-CP adapalene application is an effective acne treatment method to improve efficacy and treatment adherence.

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