Fractional carbon dioxide laser‐assisted delivery of lyophilized‐growth factors is a promising treatment modality of post‐acne scars

Abstract Background Acne scars, is a challenge for dermatologists, despite having multiple treatment modalities like microneedling, dermabrasion, Fractional CO2 Laser, dermal fillers, etc. However, monotherapy has been hardly satisfactory because of the polymorphism seen with the scars. Objective Comparison between microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars. Patients and methods This study was carried out in department of dermatology, venereology and andrology, in Kobry El-Kobba Military complex during the period (from September 2018 to July 2020 ) on 20 patients of both sexes aged from 20 to 60 years old presenting with Goodman and Baron Grade II, III, IV acne scars . Results The study revealed a statistically significant difference (p = 0.017) between Goodman and Baron scar grades on the right side of the face before and after treatment indicating that microneedling with platelet rich plasma was effective in improving acne scars. Also, there is a statistically significant difference (p = 0.010) between Goodman and Baron scar grades on the left side of the face before and after treatment, indicating that fractional CO2 laser with platelet rich plasma was effective in improving acne scars. Conclusion and recommendation Further controlled and randomized studies are needed to validate our findings in a larger cohort of patients and longer follow up. Also, number of sessions might be more than 3 sessions.

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Comparison Study of Fractional Carbon Dioxide Laser Resurfacing Using Different Fluences and Densities for Acne Scars in Asians: A Randomized Split-Face Trial

Dermatologic Surgery ◽

10.1111/dsu.12467 ◽

2014 ◽

Vol 40 (5) ◽

pp. 545-552 ◽

Cited By ~ 11

Author(s):

Xing-Hua Yuan ◽

Shu-Xia Zhong ◽

Shan-Shan Li

Keyword(s):

Carbon Dioxide ◽

Carbon Dioxide Laser ◽

Comparison Study ◽

Laser Resurfacing ◽

Acne Scars ◽

Fractional Carbon Dioxide Laser ◽

Split Face

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Ablative Fractional CO2 Laser for Facial Atrophic Acne Scars

Facial Plastic Surgery ◽

10.1055/s-0037-1606096 ◽

2018 ◽

Vol 34 (02) ◽

pp. 205-219 ◽

Cited By ~ 11

Author(s):

Yaqin Xu ◽

Yunhua Deng

Keyword(s):

Carbon Dioxide ◽

Carbon Dioxide Laser ◽

Randomized Clinical Trials ◽

Treatment Plan ◽

Acne Vulgaris ◽

Treatment Session ◽

Efficacy And Safety ◽

Acne Scars ◽

Fractional Carbon Dioxide Laser ◽

Comprehensive Search

AbstractAblative fractional carbon dioxide laser resurfacing is a well-established treatment for acne scars. However, there are limited consensus and guidelines regarding the procedure, such as its treatment plan, efficacy, and safety. In this study, we performed a systematic review to assess the efficacy and safety of the fractional carbon dioxide laser treatment procedure, and to provide evidence-based recommendations concerning its practical use on atrophic acne scars. A comprehensive search was performed in, EMBASE, Ovid, Web of Science, and Cochrane databases, using the keywords “scar(s),” “acne vulgaris,” “carbon dioxide,” and “fraction* laser(s)” for the period from January 1987 to December 2016. The initial literature search identified 337 articles. The final selection included 30 studies: 12 retrospective studies and 18 prospective randomized clinical trials. Ablative fractional carbon dioxide laser is an effective therapy for the treatment of acne scars. The treatment session, interval, and parameters should be customized for each patient. Combination therapy should be considered for ice-pick type acne scars. The use of dermocosmetics in pre- and postoperative care may be beneficial to patients.

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Effectiveness of subcision using carboxytherapy plus fractional carbon dioxide laser resurfacing in the treatment of atrophic acne scars: comparative split face study

Journal of Dermatological Treatment ◽

10.1080/09546634.2019.1595505 ◽

2019 ◽

Vol 31 (3) ◽

pp. 296-299 ◽

Cited By ~ 1

Author(s):

Ibrahim Mohamed Abdel Kareem ◽

Mohamed Ahmed Fouad ◽

Mohamed Kotb Ibrahim

Keyword(s):

Carbon Dioxide ◽

Carbon Dioxide Laser ◽

Laser Resurfacing ◽

Acne Scars ◽

Fractional Carbon Dioxide Laser ◽

Split Face

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Fractional Carbon Dioxide Laser in Treatment of Acne Scars

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.004 ◽

2015 ◽

Vol 4 (1) ◽

pp. 38-42 ◽

Cited By ~ 3

Author(s):

Andrej Petrov ◽

Vesna Pljakovska

Keyword(s):

Carbon Dioxide ◽

Carbon Dioxide Laser ◽

The Other ◽

Hypertrophic Scars ◽

Skin Damage ◽

Acne Scars ◽

The World ◽

Fractional Carbon Dioxide Laser ◽

Skin Healing ◽

Residual Lesions

BACKGROUND: Scars appear as a result of skin damage during the process of the skin healing. There are two types of acne scars, depending on whether there is a loss or accumulation of collagen: atrophic and hypertrophic. In 80-90% it comes to scars with loss of collagen compared to smaller number of hypertrophic scars and keloids.AIM: The aim of the study was to determine efficiency and safety of fractional carbon dioxide laser in the treatment of acne scars.MATERIAL AND METHODS: The study was carried out in Acibadem Sistina Clinical Hospital, Skopje at the Department of Dermatovenerology, with a total of 40 patients treated with fractional carbon dioxide laser (Lutronic eCO2). The study included patients with residual acne scars of a different type.RESULTS: Comedogenic and papular acne in our material were proportionately presented in 50% of cases, while the other half were the more severe clinical forms of acne - pustular inflammatory acne and nodulocystic acne that leave residual lesions in the form of second, third and fourth grade of scars.CONCLUSION: The experiences of our work confirm the world experiences that the best result with this method is achieved in dotted ice pick or V-shaped acne scars.

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Comparison of the efficacy of Subcision with Fractional Carbon Dioxide Laser versus Subcision with Microneedling Fractional Radiofrequency in the Treatment of Atrophic Post acne Scars

American Journal of Dermatological Research and Reviews ◽

10.28933/ajodrr-2021-03-2305 ◽

2021 ◽

pp. 44

Author(s):

Keyword(s):

Carbon Dioxide ◽

Co2 Laser ◽

Carbon Dioxide Laser ◽

Response To Treatment ◽

Percentage Reduction ◽

Acne Scars ◽

Group A ◽

Fractional Carbon Dioxide Laser ◽

Group B ◽

Carbon Dioxide Co2

Background: Many interventions have been used to treat post-acne scars, with various degrees of efficacy and adverse reactions. Multimodal approach can achieve better results for improving the physical appearance that even if minor may result in significant distress and reduced quality of life. Objective: To compare the efficacy of subcision with fractional carbon dioxide (CO2) laser and subcision with microneedling fractional radiofrequency (RF) in treating post-acne scars and to study their adverse effects. Methods: In this prospective, interventional clinical study, a total of 64 patients with post-acne scars were enrolled. The patients were randomly allocated into two groups of 32 patients each, in which group A was treated with subcision plus fractional carbon dioxide laser (CO2) and group B was treated with subcision plus microneedling fractional radiofrequency (RF) every 6 weeks for a total of four sittings. An objective score was calculated for each patient using the Goodman and Baron scale to evaluate the outcome every visit during treatment and then 3 months after completion of therapy. Results: In group A, the percentage reduction in the mean objective scores was found to be 64%. In group B, the percentage reduction in mean objective scores was found to be 42%. Most of the changes were seen in the boxcar and rolling types of scars. Conclusions: Subcision and fractional CO2 laser were considered superior over subcision with microneedling fractional (RF) technique for the treatment of post-acne scars. Boxcar and rolling types of scars showed a high response to treatment than icepick scars

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