scholarly journals Topographic principles of cortical fluid-attenuated inversion recovery signal in temporal lobe epilepsy

Epilepsia ◽  
2018 ◽  
Vol 59 (3) ◽  
pp. 627-635 ◽  
Author(s):  
Sophie Adler ◽  
Seok-Jun Hong ◽  
Min Liu ◽  
Torsten Baldeweg ◽  
J. Helen Cross ◽  
...  
2011 ◽  
Vol 69 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Pedro Paulo Vasconcellos Varella ◽  
Joselita Ferreira Carvalho Santiago ◽  
Henrique Carrete Jr. ◽  
Elisa Mieko Suemitsu Higa ◽  
Elza Márcia Targas Yacubian ◽  
...  

We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.


2021 ◽  
Vol 170 ◽  
pp. 106540
Author(s):  
Daichi Sone ◽  
Noriko Sato ◽  
Yukio Kimura ◽  
Norihide Maikusa ◽  
Yoko Shigemoto ◽  
...  

Epilepsia ◽  
2013 ◽  
Vol 54 (12) ◽  
pp. 2174-2183 ◽  
Author(s):  
Emiko Morimoto ◽  
Tomohisa Okada ◽  
Mitsunori Kanagaki ◽  
Akira Yamamoto ◽  
Yasutaka Fushimi ◽  
...  

2019 ◽  
Vol 33 (7) ◽  
pp. 986-995 ◽  
Author(s):  
Elizabeth Stewart ◽  
Cathy Catroppa ◽  
Linda Gonzalez ◽  
Deepak Gill ◽  
Richard Webster ◽  
...  

2012 ◽  
Vol 43 (01) ◽  
Author(s):  
VE Bernedo Paredes ◽  
H Schwartz ◽  
M Gartenschläger ◽  
M Gartenschläger ◽  
HG Buchholz ◽  
...  

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
C Waisburg ◽  
E Sherman ◽  
L Byron ◽  
A Chapman ◽  
G Ainsworth ◽  
...  

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