scholarly journals Continuous digital hypothermia prevents lamellar failure in the euglycaemic hyperinsulinaemic clamp model of equine laminitis

2019 ◽  
Vol 51 (5) ◽  
pp. 658-664 ◽  
Author(s):  
S. M. Stokes ◽  
J. K. Belknap ◽  
J. B. Engiles ◽  
D. Stefanovski ◽  
F. R. Bertin ◽  
...  
Keyword(s):  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp

Glucose consumption by various tissues in pregnant rats: effects of a 6‐day euglycaemic hyperinsulinaemic clamp

1998 ◽  
Vol 164 (3) ◽  
pp. 325-334 ◽  
Author(s):  
NIEUWENHUIZEN ◽  
SCHUILING ◽  
BONEN ◽  
PAANS ◽  
VAALBURG ◽  
...  
Keyword(s):  
Glucose Consumption ◽  
Pregnant Rats ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp

scholarly journals Insulin resistance in polycystic ovary syndrome: a systematic review and meta-analysis of euglycaemic–hyperinsulinaemic clamp studies

2016 ◽  
Vol 31 (11) ◽  
pp. 2619-2631 ◽  
Author(s):  
Samantha Cassar ◽  
Marie L. Misso ◽  
William G. Hopkins ◽  
Christopher S. Shaw ◽  
Helena J. Teede ◽  
...  
Keyword(s):  
Systematic Review ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Ovary Syndrome ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp

scholarly journals Hyperinsulinaemia increases insulin action in vivo in white adipose tissue but not in muscles

1990 ◽  
Vol 272 (1) ◽  
pp. 255-257 ◽  
Author(s):  
F Takao ◽  
M C Laury ◽  
A Ktorza ◽  
L Picon ◽  
L Pénicaud
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Skeletal Muscles ◽  
Insulin Action ◽  
Glucose Utilization ◽  
Rat Tissues ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp

The effect of 4 days of stable hyperglycaemia and resulting hyperinsulinaemia on insulin-induced glucose utilization by individual rat tissues was studied in vivo. The treatment produced a net increase in the glucose utilization index under both basal and insulin-stimulated (euglycaemic/hyperinsulinaemic clamp) conditions in white adipose tissue. On the contrary, glucose utilization was unchanged in aerobic muscles but was decreased in glycolytic skeletal muscles during the clamp.

Recovery of 13C in Breath from Infused NaH13CO3 Increases During Euglycaemic Hyperinsulinaemia

1994 ◽  
Vol 87 (4) ◽  
pp. 415-419 ◽  
Author(s):  
D. Reaich ◽  
K. A. Graham ◽  
B. G. Cooper ◽  
C. M. Scrimgeour ◽  
T. H. J. Goodship
Keyword(s):  
Potato Starch ◽  
Normal Subjects ◽  
Substrate Oxidation ◽  
Time Dependent ◽  
Constant Infusion ◽  
The Third ◽  
Hyperinsulinaemic Clamp ◽  
Significant Difference ◽  
Euglycaemic Hyperinsulinaemic Clamp ◽  
Made In

1. The effect of euglycaemic hyperinsulinaemia on the recovery of 13C in expired CO2 has been assessed in six normal subjects. Each was studied on three occasions: once with a 6 h primed constant infusion of NaH13CO3 combined with a euglycaemic hyperinsulinaemic clamp for the last 3 h (study 1), once with a 6h primed constant infusion of NaH13CO3 alone (study 2) and once with a 6 h infusion of normal saline combined with a hyperinsulinaemic clamp for the last 3 h (study 3). Measurements of 13C enrichment of expired CO2 were made in the third and sixth hour of each infusion. 2. There was no significant increase in enrichment during study 3 (3 h 0.00047 ± 0.00016 versus 6 h 0.00069 ± 0.00028 atom per cent excess) with potato-starch-derived D-glucose used to maintain eugly-caemia. 13C recovery increased in the sixth hour of both study 1 and 2 (study 1: 3 h 74.4 ± 2.0 versus 6 h 85.5 ± 2.6%, P < 0.01; study 2: 3 h 72.1 ± 2.4 versus 6 h 81.7 ± 1.4%, P < 0.01). There was no significant difference in recovery between studies 1 and 2. 3. These results suggest that increased recovery during a sequential euglycaemic clamp is predominantly time-dependent. Studies which use this technique to examine the effect of insulin on substrate oxidation should take this into account.

scholarly journals Serum 25-hydroxyvitamin D and insulin resistance in people at high risk of cardiovascular disease: a euglycaemic hyperinsulinaemic clamp study

2016 ◽  
Vol 85 (3) ◽  
pp. 386-392 ◽  
Author(s):  
I.R. Wallace ◽  
M.C. McKinley ◽  
C.T. McEvoy ◽  
L.L. Hamill ◽  
C.N. Ennis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
High Risk ◽  
Hydroxyvitamin D ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp ◽  
25 Hydroxyvitamin D ◽  
Clamp Study

scholarly journals The link between metabolic features and TSH levels in polycystic ovary syndrome is modulated by the body weight: an euglycaemic–hyperinsulinaemic clamp study

2016 ◽  
Vol 175 (5) ◽  
pp. 433-441 ◽  
Author(s):  
Valeria Tagliaferri ◽  
Daniela Romualdi ◽  
Maurizio Guido ◽  
Antonio Mancini ◽  
Simona De Cicco ◽  
...  
Keyword(s):  
Body Weight ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
The Body ◽  
Oral Glucose ◽  
Ovary Syndrome ◽  
Insulin Metabolism ◽  
Hyperinsulinaemic Clamp ◽  
Euglycaemic Hyperinsulinaemic Clamp ◽  
Tsh Levels

Objective To evaluate the link among thyroid function, glucose/insulin metabolism and steroid hormones in women with polycystic ovary syndrome (PCOS), and to verify if the body mass index (BMI) might influence the interplay between PCOS features and subclinical hypothyroidism (SCH). Study design Case–control study conducted from January to December 2014. Methods One-hundred fifty-four young women with PCOS, according to Rotterdam criteria, and 88 controls were enrolled in an academic research environment. Anthropometric evaluation, hormonal and lipid assays, oral glucose tolerance test (OGTT) and euglycaemic–hyperinsulinaemic clamp were performed. Hirsutism was assessed with the Ferriman–Gallwey (FG) score. Main results SCH was found in 14% of PCOS subjects and in 1% of controls (P < 0.01). In PCOS women, TSH levels were directly correlated with fasting glycaemia, but not with other hormonal and metabolic parameters. When PCOS patients were classified on the basis of BMI, TSH levels significantly correlated with insulin secretion, insulin resistance, DHEAS and cortisol levels in obese PCOS women. Inverse correlations were found between TSH and both oestradiol and SHBG in the same group. In nonobese PCOS patients, only waist-to-hip ratio values were correlated with TSH. The prevalence of SCH was not different between nonobese and obese PCOS groups (14 and 15% respectively). However, SCH was associated with higher levels of insulin, DHEAS, cortisol and FG score only in the obese subgroup. Conclusions Our data confirm that the prevalence of SCH is increased in PCOS women. The presence of SCH is associated with endocrine and metabolic imbalances of PCOS, and the excessive body weight seems to promote this interplay.

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