Recovery of 13C in Breath from Infused NaH13CO3 Increases During Euglycaemic Hyperinsulinaemia

1994 ◽  
Vol 87 (4) ◽  
pp. 415-419 ◽  
Author(s):  
D. Reaich ◽  
K. A. Graham ◽  
B. G. Cooper ◽  
C. M. Scrimgeour ◽  
T. H. J. Goodship
Keyword(s):  
Potato Starch ◽  
Normal Subjects ◽  
Substrate Oxidation ◽  
Time Dependent ◽  
Constant Infusion ◽  
The Third ◽  
Hyperinsulinaemic Clamp ◽  
Significant Difference ◽  
Euglycaemic Hyperinsulinaemic Clamp ◽  
Made In

1. The effect of euglycaemic hyperinsulinaemia on the recovery of 13C in expired CO2 has been assessed in six normal subjects. Each was studied on three occasions: once with a 6 h primed constant infusion of NaH13CO3 combined with a euglycaemic hyperinsulinaemic clamp for the last 3 h (study 1), once with a 6h primed constant infusion of NaH13CO3 alone (study 2) and once with a 6 h infusion of normal saline combined with a hyperinsulinaemic clamp for the last 3 h (study 3). Measurements of 13C enrichment of expired CO2 were made in the third and sixth hour of each infusion. 2. There was no significant increase in enrichment during study 3 (3 h 0.00047 ± 0.00016 versus 6 h 0.00069 ± 0.00028 atom per cent excess) with potato-starch-derived D-glucose used to maintain eugly-caemia. 13C recovery increased in the sixth hour of both study 1 and 2 (study 1: 3 h 74.4 ± 2.0 versus 6 h 85.5 ± 2.6%, P < 0.01; study 2: 3 h 72.1 ± 2.4 versus 6 h 81.7 ± 1.4%, P < 0.01). There was no significant difference in recovery between studies 1 and 2. 3. These results suggest that increased recovery during a sequential euglycaemic clamp is predominantly time-dependent. Studies which use this technique to examine the effect of insulin on substrate oxidation should take this into account.

STUDY OF A LARGE STEROID SPECTRUM IN NORMAL SUBJECTS AND HYPERTENSIVE PATIENTS

1960 ◽  
Vol XXXV (III) ◽  
pp. 413-425 ◽  
Author(s):  
Jacques Genest ◽  
Erich Koiw ◽  
Wojciech Nowaczynski ◽  
Thomas Sandor
Keyword(s):  
Healthy Volunteers ◽  
Intravenous Infusion ◽  
Fold Increase ◽  
Normal Subjects ◽  
Extensive Study ◽  
Malignant Hypertension ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
Normotensive Subjects ◽  
Made In

ABSTRACT An extensive study made in 110 normal subjects and hypertensive patients has shown a statistically significant 2-fold mean increase in urinary aldosterone excretion and a statistically significant mean decrease in urinary pregnanetriol and in pregnanetriol/aldosterone ratio from groups of patients with essential, renal and malignant hypertension as compared to that of normal subjects. No significant difference was found in cortisone, cortisol and their tetrahydro derivatives, aetiocholanolone and the tetrahydro derivative of 17,21-dihydroxy-pregn-4-ene-3,20-dione excretion of hypertensive patients as compared to normotensive subjects. In four healthy volunteers, intravenous infusion of angiotensin was followed by a 2 to 10-fold increase in urinary aldosterone excretion.

scholarly journals Effect of Chlorpromazine on Rem Rebound in Normal Volunteers

1972 ◽  
Vol 17 (6) ◽  
pp. 463-469
Author(s):  
J. Naiman ◽  
R. Poitras ◽  
F. Engelsmann
Keyword(s):  
Analysis Of Variance ◽  
Total Sleep Time ◽  
Normal Subjects ◽  
Sleep Time ◽  
Normal Volunteers ◽  
The Third ◽  
Significant Difference ◽  
Dependent Variables ◽  
Rem Latency ◽  
Main Effects

The effect of chlorpromazine on the REM deprivation rebound was studied. Five normal subjects participated in the experiment which consisted of three periods of nine nights each. The first period was without medication, the second with medication and the third again without medication. Four dependent variables — Total Sleep Time, REM latency, REM time and REM percentage — were measured in each period as follows: baseline — three nights, REM deprivation — two nights and recovery — four nights. Analysis of variance (three-way classification) was computed in order to evaluate both the main effects as well as the interaction between medication and sleep conditions. The results showed significant difference over the three conditions of sleep — baseline, REM deprivation and recovery. While there were no significant differences due to medication the replication of the measurements in the same subjects proved to be a slightly significant source of the variance of the scores in all variables except REM latency.

Auditory Selective Attention in Cerebral-Palsied Individuals

1985 ◽  
Vol 16 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Lee Ann Laraway
Keyword(s):  
Selective Attention ◽  
White Noise ◽  
Normal Subjects ◽  
Auditory Selective Attention ◽  
Normal Individuals ◽  
Significant Difference

The purpose of this study was to determine whether there is a statistically significant difference between the auditory selective attention abilities of normal and cerebral-palsied individuals. Twenty-three cerebral-palsied and 23 normal subjects between the ages of 5 and 21 were asked to repeat a series of 30 items consisting of from 2 to 4 digits in the presence of intermittent white noise. Results of the study indicate that cerebral-palsied individuals perform significantly poorer than normal individuals when the stimulus is accompanied by noise. Noise was not a significant factor in the performance of the normal subjects regardless of age.

A Specific Immunologic Assay for Functional Plasminogen Activator Inhibitor 1 in Plasma – Standardized Measurements of the Inhibitor and Related Parameters in Patients with Venous Thromboembolic Disease

1992 ◽  
Vol 68 (05) ◽  
pp. 486-494 ◽  
Author(s):  
Malou Philips ◽  
Anne-Grethe Juul ◽  
Johan Selmer ◽  
Bent Lind ◽  
Sixtus Thorsen
Keyword(s):  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Normal Subjects ◽  
Tissue Type ◽  
Blood Collection ◽  
Plasminogen Activator Inhibitor 1 ◽  
Type Plasminogen Activator ◽  
Significant Difference ◽  
Activator Inhibitor ◽  
Pai 1

SummaryA new assay for functional plasminogen activator inhibitor 1 (PAI-1) in plasma was developed. The assay is based on the quantitative conversion of PAI-1 to urokinase-type plasminogen activator (u-PA)-PAI-l complex the concentration of which is then determined by an ELISA employing monoclonal anti-PAI-1 as catching antibody and monoclonal anti-u-PA as detecting antibody. The assay exhibits high sensitivity, specificity, accuracy, and precision. The level of functional PAI-1, tissue-type plasminogen activator (t-PA) activity and t-PA-PAI-1 complex was measured in normal subjects and in patients with venous thromboembolism in a silent phase. Blood collection procedures and calibration of the respective assays were rigorously standardized. It was found that the patients had a decreased fibrinolytic capacity. This could be ascribed to high plasma levels of PAI-1. The release of t-PA during venous occlusion of an arm for 10 min expressed as the increase in t-PA + t-PA-PAI-1 complex exhibited great variation and no significant difference could be demonstrated between the patients with a thrombotic tendency and the normal subjects.

Comparative Plasma Heparin Levels after Subcutaneous Sodium and Calcium Heparin

1978 ◽  
Vol 40 (02) ◽  
pp. 397-406 ◽  
Author(s):  
Joyce Low ◽  
J C Biggs
Keyword(s):  
Peak Plasma ◽  
Plasma Concentrations ◽  
Factor Xa ◽  
Normal Subjects ◽  
Sodium Salts ◽  
Sodium Heparin ◽  
Significant Difference ◽  
Heparin Plasma ◽  
Calcium Heparin ◽  
Plasma Heparin

SummaryComparative plasma heparin levels were measured in normal subjects injected subcutaneously with 5,000 units of the sodium and calcium salts of heparin. Plasma heparin levels were measured up to 7 hr post-injection by an anti-factor Xa assay (Denson and Bonnar 1973). Preliminary studies indicated that heparin levels were reproducible in subjects who received two injections of the same heparin. Peak plasma concentrations (Cmax) and the time at which peak concentration was reached (Tmax) varied greatly from subject to subject. In one group of subjects (15) two commonly used heparins, a sodium heparin (Evans) and a calcium heparin (Choay) were compared. Peak heparin concentrations were not significantly different. However the Tmax for the sodium heparin (1.5 hr) was significantly earlier than the Tmax for the calcium heparin (3 hr) and this was not due to a difference in the volume of the two heparin injections. No significant difference could be detected in the plasma clearance rate and the molecular weight distribution of the two heparins.In two other groups of subjects, sodium and calcium preparations from two manufacturers were compared. In general, the sodium salts gave rise to significantly higher plasma concentrations, which could be interpreted as a greater bioavailability of sodium salts. These results indicate that the salt of the heparin can influence the plasma concentration achieved after subcutaneous injection.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

IMMUNOLOGICAL REACTIVITY OF INSULIN IN HUMAN SERUM

1966 ◽  
Vol 53 (4) ◽  
pp. 673-680 ◽  
Author(s):  
Torsten Deckert ◽  
Kai R. Jorgensen
Keyword(s):  
Normal Subjects ◽  
The Other ◽  
Human Pancreas ◽  
Porcine Pancreas ◽  
Crystalline Insulin ◽  
Endogenous Insulin ◽  
Significant Difference ◽  
Human Sera ◽  
Normal Human ◽  
The One

ABSTRACT The purpose of this study was to investigate whether a difference could be demonstrated between crystalline insulin extracted from normal human pancreas, and crystalline insulin extracted from bovine and porcine pancreas. Using Hales & Randle's (1963) immunoassay no immunological differences could be demonstrated between human and pig insulin. On the other hand, a significant difference was found, between pig and ox insulin. An attempt was also made to determine whether an immunological difference could be demonstrated between crystalline pig insulin and crystalline human insulin from non diabetic subjects on the one hand and endogenous, circulating insulin from normal subjects, obese subjects and diabetic subjects on the other. No such difference was found. From these experiments it is concluded that endogenous insulin in normal, obese and diabetic human sera is immunologically identical with human, crystalline insulin from non diabetic subjects and crystalline pig insulin.

KERCH STRAIT IN KAMYSH-BURUN SPIT AREA: HIGH-RESOLUTION SEISMOACOUSTIC APPROACH

2018 ◽  
Author(s):  
В. Зинько ◽  
V. Zin'ko ◽  
А. Зверев ◽  
A. Zverev ◽  
М. Федин ◽  
...  
Keyword(s):  
High Resolution ◽  
Fracture Zone ◽  
Sedimentary Cover ◽  
Sedimentary Rocks ◽  
The West ◽  
Early Generation ◽  
The Third ◽  
Azov Sea ◽  
Kerch Strait ◽  
Made In

The seismoacoustical investigations was made in the western part of the Kerch strait (Azov sea) near Kamysh-Burun spit. The fracture zone with dislocated sedimentary rocks layers and buried erosional surface was revealed to the west of spit. Three seismofacial units was revealed to the east of spit. The first unit was modern sedimentary cover. The second ones has cross-bedding features and was, probably, the part of early generation of Kamysh-Burun spit, which lied to the east of its modern position. The lower border of the second unit is the erosional surface supposed of phanagorian age. The third unit is screened by acoustic shedows in large part.

Introduction

2018 ◽  
Author(s):  
Nora Goldschmidt ◽  
Barbara Graziosi
Keyword(s):  
Material Culture ◽  
The Body ◽  
Specific Site ◽  
Entire Volume ◽  
The Third ◽  
Religious Significance ◽  
Classical Poetry ◽  
Life Of The Mind ◽  
The Mind ◽  
Made In

The Introduction sheds light on the reception of classical poetry by focusing on the materiality of the poets’ bodies and their tombs. It outlines four sets of issues, or commonplaces, that govern the organization of the entire volume. The first concerns the opposition between literature and material culture, the life of the mind vs the apprehensions of the body—which fails to acknowledge that poetry emerges from and is attended to by the mortal body. The second concerns the religious significance of the tomb and its location in a mythical landscape which is shaped, in part, by poetry. The third investigates the literary graveyard as a place where poets’ bodies and poetic corpora are collected. Finally, the alleged ‘tomb of Virgil’ provides a specific site where the major claims made in this volume can be most easily be tested.

The Hydraulic Operation of Lathes for the Production of Shells

1944 ◽  
Vol 151 (1) ◽  
pp. 70-86
Author(s):  
W. Littlejohn Philip
Keyword(s):  
Machine Tools ◽  
Hydraulic Power ◽  
The Third ◽  
Hydraulic Machine ◽  
Hydraulic Machinery ◽  
Simple Machines ◽  
High Level ◽  
Shell Production ◽  
Hydraulic Operation ◽  
Made In

The paper is limited to the application of hydraulic power to lathes designed for shell making although, in the author's opinion, there is an immense field for the application of the same principles in other directions. Self-contained hydraulic machine tools have been dealt with by Mr. H. C. Town,† but in the system to be described all the machines are operated from a central hydraulic plant. Three complete installations on this principle have been established by the author, and the present paper contains an account of this work from the first experiments in 1915 until about four years ago. The first plant was constructed in 1915 for the production of 3·29-inch shells, known as “18-pounders”, from the solid bar. The output was 2,000 shells per week of 135 hours, with girl operators working on three shifts. The second plant was put down in 1916–17 for an output of 500 9·2-inch howitzer shells per week of 135 hours, also with girls working on three shifts. The third plant is of recent design. It was started in 1938 for the production of 3·45-inch shells, known as “25-pounders”; and was laid out for an output of 1,000 shells per week of 47 hours. This plant included four types of hydraulic lathes which the author was engaged to design for the War Office. Soon after the commencement of the last war in 1914 it became evident that shell production would have to be greatly increased, and engineering firms were pressed to take up shell manufacture. The author, on behalf of his firm, undertook to help in the movement, and he at once set about the construction of some simple machines for the job. These conformed on general lines to the practice of the period as regards design and operation. He soon realized, however, that drastic changes would have to be made if production was to reach the high level that circumstances demanded. Although quite familiar with hydraulic machinery of various types and of many applications in presses and certain types of heavy tools, he was not aware of any instance in which hydraulic power had been applied to the movements of a lathe. It appeared to him, nevertheless, that it would be possible to construct a very useful machine on these lines, and he accordingly started immediately to carry out experiments and to prepare designs. It was considered essential that machines for the duty which the author had in mind should be much heavier and more rigid than the ordinary machines of the time, so that they should be free from vibration and “chatter” or spring with the heaviest possible cutting. The standard of rigidity aimed at was that which would permit a half-crown coin to remain balanced on edge on the moving saddle or turret while the tools were making the heaviest cuts. This object was achieved, and the demonstration was frequently made in the presence of those who came to see the lathes at work.

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