scholarly journals Does autoimmune vitiligo protect against COVID‐19 disease?

2021 ◽  
Author(s):  
Nicoline F. Post ◽  
Rosalie M. Luiten ◽  
Albert Wolkerstorfer ◽  
Marcel Bekkenk ◽  
Markus Böhm
Keyword(s):  
Autoimmune Vitiligo

scholarly journals High Frequency of Skin-homing Melanocyte-specific Cytotoxic T Lymphocytes in Autoimmune Vitiligo

1998 ◽  
Vol 188 (6) ◽  
pp. 1203-1208 ◽  
Author(s):  
Graham S. Ogg ◽  
P. Rod Dunbar ◽  
Pedro Romero ◽  
Ji-Li Chen ◽  
Vincenzo Cerundolo
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Ex Vivo ◽  
Hla Class I ◽  
Peripheral Tolerance ◽  
Skin Homing ◽  
Autoimmune Vitiligo ◽  
Destruction Of Melanocytes

Vitiligo is an autoimmune condition characterized by loss of epidermal melanocytes. Using tetrameric complexes of human histocompatibility leukocyte antigen (HLA) class I to identify antigen-specific T cells ex vivo, we observed high frequencies of circulating MelanA-specific, A*0201-restricted cytotoxic T lymphocytes (A2–MelanA tetramer+ CTLs) in seven of nine HLA-A*0201–positive individuals with vitiligo. Isolated A2–MelanA tetramer+ CTLs were able to lyse A*0201-matched melanoma cells in vitro and their frequency ex vivo correlated with extent of disease. In contrast, no A2–MelanA tetramer+ CTL could be identified ex vivo in all four A*0201-negative vitiligo patients or five of six A*0201-positive asymptomatic controls. Finally, we observed that the A2–MelanA tetramer+ CTLs isolated from vitiligo patients expressed high levels of the skin homing receptor, cutaneous lymphocyte-associated antigen, which was absent from the CTLs seen in the single A*0201-positive normal control. These data are consistent with a role of skin-homing autoreactive melanocyte-specific CTLs in causing the destruction of melanocytes seen in autoimmune vitiligo. Lack of homing receptors on the surface of autoreactive CTLs could be a mechanism to control peripheral tolerance in vivo.

Seven cases of vitiligo complicated by atopic dermatitis: suggestive new spectrum of autoimmune vitiligo

2012 ◽  
Vol 22 (2) ◽  
pp. 279-280 ◽  
Author(s):  
Atsushi Tanemura ◽  
Tomoko Yajima ◽  
Mayuko Nakano ◽  
Megumi Nishioka ◽  
Saori Itoi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Autoimmune Vitiligo

Therapeutic implications of autoimmune vitiligo T cells

2006 ◽  
Vol 16 (Supplement 1) ◽  
pp. S40
Author(s):  
P. Oyarbide-Valencia ◽  
J. van den Boorn ◽  
M. Li ◽  
C. Denman ◽  
J. Carlson ◽  
...  
Keyword(s):  
T Cells ◽  
Therapeutic Implications ◽  
Autoimmune Vitiligo

scholarly journals A central role for inducible heat-shock protein 70 in autoimmune vitiligo

2013 ◽  
Vol 22 (9) ◽  
pp. 566-569 ◽  
Author(s):  
Jeffrey A. Mosenson ◽  
Jonathan M. Eby ◽  
Claudia Hernandez ◽  
I. Caroline Le Poole
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Autoimmune Vitiligo

scholarly journals Dysregulation of Circular Antigen-Specific T Cells Anergy in Autoimmune Vitiligo

2018 ◽  
Vol 08 (03) ◽  
pp. 133-139
Author(s):  
Atsushi Tanemura ◽  
Lingli Yang ◽  
Ichiro Katayama
Keyword(s):  
T Cells ◽  
Autoimmune Vitiligo

scholarly journals Autoimmune Vitiligo Does Not Require the Ongoing Priming of Naive CD8 T Cells for Disease Progression or Associated Protection against Melanoma

2014 ◽  
Vol 192 (4) ◽  
pp. 1433-1439 ◽  
Author(s):  
Katelyn T. Byrne ◽  
Peisheng Zhang ◽  
Shannon M. Steinberg ◽  
Mary Jo Turk
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Cd8 T Cells ◽  
Autoimmune Vitiligo

scholarly journals Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 ◽  
Vol 182 (5) ◽  
pp. 1609-1614 ◽  
Author(s):  
I Hara ◽  
Y Takechi ◽  
A N Houghton
Keyword(s):  
Immune Responses ◽  
Coat Color ◽  
Lung Metastases ◽  
Passive Immunization ◽  
Tumor Rejection ◽  
Immune Recognition ◽  
Differentiation Antigen ◽  
Differentiation Antigens ◽  
Autoimmune Vitiligo ◽  
Tyrosinase Related Protein

The immune system can recognize differentiation antigens that are selectively expressed on malignant cells and their normal cell counterparts. However, it is uncertain whether immunity to differentiation antigens can effectively lead to tumor rejection. The mouse brown locus protein, gp75 or tyrosinase-related protein 1, is a melanocyte differentiation antigen expressed by melanomas and normal melanocytes. The gp75 antigen is recognized by autoantibodies and autoreactive T cells in persons with melanoma. To model autoimmunity against a melanocyte differentiation antigen, mouse antibodies against gp75 were passively transferred into tumor-bearing mice. Passive immunization with a mouse monoclonal antibody against gp75 induced protection and rejection of both subcutaneous tumors and lung metastases in syngeneic C57BL/6 mice, including established tumors. Passive immunity produced coat color alterations but only in regenerating hairs. This system provides a model for autoimmune vitiligo and shows that immune responses to melanocyte differentiation antigens can influence mouse coat color. Immune recognition of a melanocyte differentiation antigen can reject tumors, providing a basis for targeting tissue autoantigens expressed on cancer.

scholarly journals Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants

2016 ◽  
Vol 48 (11) ◽  
pp. 1418-1424 ◽  
Author(s):  
Ying Jin ◽  
Genevieve Andersen ◽  
Daniel Yorgov ◽  
Tracey M Ferrara ◽  
Songtao Ben ◽  
...  
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Regulatory Variants ◽  
Genome Wide ◽  
Autoimmune Vitiligo ◽  
Key Pathways

scholarly journals Alterations in Blood Leukocyte Populations in Smyth Line Chickens with Autoimmune Vitiligo

1996 ◽  
Vol 75 (3) ◽  
pp. 351-356 ◽  
Author(s):  
G.F. ERF ◽  
J.R. SMYTH
Keyword(s):  
Autoimmune Vitiligo ◽  
Blood Leukocyte ◽  
Leukocyte Populations
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