scholarly journals Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review

2021 ◽  
Vol 30 (10) ◽  
pp. 1546-1553
Author(s):  
Rong Tao ◽  
Ruoyu Li ◽  
Ruojun Wang
Keyword(s):  
Systematic Review ◽  
Seborrheic Dermatitis ◽  
Skin Microbiome

scholarly journals Complete Genome Sequence of Malassezia restricta CBS 7877, an Opportunist Pathogen Involved in Dandruff and Seborrheic Dermatitis

2019 ◽  
Vol 8 (6) ◽  
Author(s):  
Stanislas C. Morand ◽  
Morgane Bertignac ◽  
Agnes Iltis ◽  
Iris C. R. M. Kolder ◽  
Walter Pirovano ◽  
...  
Keyword(s):  
Human Skin ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Seborrheic Dermatitis ◽  
Skin Microbiome ◽  
Basidiomycetous Yeasts ◽  
Content Type ◽  
Opportunist Pathogen ◽  
Malassezia Restricta

Malassezia restricta, one of the predominant basidiomycetous yeasts present on human skin, is involved in scalp disorders. Here, we report the complete genome sequence of the lipophilic Malassezia restricta CBS 7877 strain, which will facilitate the study of the mechanisms underlying its commensal and pathogenic roles within the skin microbiome.

scholarly journals Cutaneous Malassezia: Commensal, Pathogen, or Protector?

2021 ◽  
Vol 10 ◽  
Author(s):  
Shree Harsha Vijaya Chandra ◽  
Ramasamy Srinivas ◽  
Thomas L. Dawson ◽  
John E. Common
Keyword(s):  
Rational Design ◽  
Health Knowledge ◽  
Ductal Carcinoma ◽  
Genetic Manipulation ◽  
Seborrheic Dermatitis ◽  
Treatment Options ◽  
Pancreatic Ductal Carcinoma ◽  
Skin Microbiome ◽  
Targeted Interventions ◽  
Host Microbe Interactions

The skin microbial community is a multifunctional ecosystem aiding prevention of infections from transient pathogens, maintenance of host immune homeostasis, and skin health. A better understanding of the complex milieu of microbe-microbe and host-microbe interactions will be required to define the ecosystem’s optimal function and enable rational design of microbiome targeted interventions. Malassezia, a fungal genus currently comprising 18 species and numerous functionally distinct strains, are lipid-dependent basidiomycetous yeasts and integral components of the skin microbiome. The high proportion of Malassezia in the skin microbiome makes understanding their role in healthy and diseased skin crucial to development of functional skin health knowledge and understanding of normal, healthy skin homeostasis. Over the last decade, new tools for Malassezia culture, detection, and genetic manipulation have revealed not only the ubiquity of Malassezia on skin but new pathogenic roles in seborrheic dermatitis, psoriasis, Crohn’s disease, and pancreatic ductal carcinoma. Application of these tools continues to peel back the layers of Malassezia/skin interactions, including clear examples of pathogenicity, commensalism, and potential protective or beneficial activities creating mutualism. Our increased understanding of host- and microbe-specific interactions should lead to identification of key factors that maintain skin in a state of healthy mutualism or, in turn, initiate pathogenic changes. These approaches are leading toward development of new therapeutic targets and treatment options. This review discusses recent developments that have expanded our understanding of Malassezia’s role in the skin microbiome, with a focus on its multiple roles in health and disease as commensal, pathogen, and protector.

scholarly journals The role of the skin microbiome in atopic dermatitis: a systematic review

2017 ◽  
Vol 177 (5) ◽  
pp. 1272-1278 ◽  
Author(s):  
R.D. Bjerre ◽  
J. Bandier ◽  
L. Skov ◽  
L. Engstrand ◽  
J.D. Johansen
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Skin Microbiome

Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review

2016 ◽  
Vol 18 (2) ◽  
pp. 193-213 ◽  
Author(s):  
Aditya K. Gupta ◽  
Sarah G. Versteeg
Keyword(s):  
Systematic Review ◽  
Topical Treatment ◽  
Seborrheic Dermatitis

scholarly journals Features of the Skin Microbiota in Common Inflammatory Skin Diseases

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 962
Author(s):  
Iva Ferček ◽  
Liborija Lugović-Mihić ◽  
Arjana Tambić-Andrašević ◽  
Diana Ćesić ◽  
Ana Gverić Grginić ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Bacterial Species ◽  
Clinical Manifestations ◽  
Skin Microbiome ◽  
Bacterial Strains ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Bacterial Microbiome ◽  
Inflammatory Skin

Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term “microbiome” comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation, and consequently an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. The skin microbiome exhibits spatial distribution associated with the microenvironment (sebaceous, moist, and dry areas). However, although disturbance of the skin microbiome can lead to a number of pathological conditions and diseases, it is still not clear whether skin diseases result from change in the microbiome or cause such a change. Thus far, the skin microbiome has been studied in atopic dermatitis, seborrheic dermatitis, psoriasis, acne, and rosacea. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved the understanding of disease development, diagnostics, and therapeutics. The identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development of more effective therapies.

Systematic Review of Oral Treatments for Seborrheic Dermatitis

2013 ◽  
Vol 28 (1) ◽  
pp. 16-26 ◽  
Author(s):  
A.K. Gupta ◽  
M. Richardson ◽  
M. Paquet
Keyword(s):  
Systematic Review ◽  
Seborrheic Dermatitis

scholarly journals The skin microbiome in psoriatic disease: A systematic review and critical appraisal

2019 ◽  
Vol 2 ◽  
pp. 100009 ◽  
Author(s):  
Meital Yerushalmi ◽  
Ofir Elalouf ◽  
Melanie Anderson ◽  
Vinod Chandran
Keyword(s):  
Systematic Review ◽  
Critical Appraisal ◽  
Skin Microbiome ◽  
Psoriatic Disease

scholarly journals Neutral Processes Drive Seasonal Assembly of the Skin Mycobiome

mSystems ◽  
2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Xinzhao Tong ◽  
Marcus H. Y. Leung ◽  
David Wilkins ◽  
Hedwig H. L. Cheung ◽  
Patrick K. H. Lee
Keyword(s):  
Human Skin ◽  
Fungal Community ◽  
Community Dynamics ◽  
Seborrheic Dermatitis ◽  
Temporal Stability ◽  
Skin Microbiome ◽  
Skin Microbiota ◽  
Ecological Processes ◽  
Significant Difference ◽  
Healthy Chinese

ABSTRACT The importance of microorganisms to human skin health has led to a growing interest in the temporal stability of skin microbiota. Here we investigated the dynamics and assembly of skin fungal communities (mycobiomes) with amplicon sequencing of samples collected from multiple sites on 24 healthy Chinese individuals across four seasons (in the order of winter, spring, summer, and autumn in a calendar year). We found a significant difference in community compositions between individuals, and intrapersonal community variation increased over time at all body sites. Within each season, the frequency of occurrence of most operational taxonomic units (OTUs) was well fitted by a neutral model, highlighting the importance of stochastic forces such as passive dispersal and ecological drift in skin community assembly. Despite the significant richness contributed by neutrally distributed OTUs, skin coassociation networks were dominated by taxa well-adapted to multiple body sites (forehead, forearm, and palm), although hub species were disproportionately rare. Taken together, these results suggest that while skin mycobiome assembly is a predominantly neutral process, taxa that could be under the influence of selective forces (e.g., host selection) are potentially key to the structure of a community network. IMPORTANCE Fungi are well recognized members of the human skin microbiota and are crucial to cutaneous health. Common cutaneous diseases such as seborrheic dermatitis and dermatophytes are linked to fungal species. Most studies related to skin microbial community dynamics have focused on Western subjects, while non-Western individuals are understudied. In this study, we explore the seasonal changes of the skin mycobiome in a healthy Chinese cohort and identify ecological processes that could possibly give rise to such variations. Our work reveals the dynamic nature of host skin fungal community, highlighting the dominant roles neutral forces play in the seasonal assembly of skin mycobiome. This study provides insight into the microbial ecology of the human skin microbiome and fills a knowledge gap in the literature regarding the dynamics of skin fungal community.

scholarly journals Diagnostic Accuracy of Trichoscopy in Inflammatory Scalp Diseases: A Systematic Review

Dermatology ◽  
2021 ◽  
pp. 1-10
Author(s):  
Joanna Golińska ◽  
Marta Sar-Pomian ◽  
Lidia Rudnicka
Keyword(s):  
Systematic Review ◽  
Contact Dermatitis ◽  
Lupus Erythematosus ◽  
Seborrheic Dermatitis ◽  
Pemphigus Vulgaris ◽  
Discoid Lupus Erythematosus ◽  
Pemphigus Foliaceus ◽  
Lichen Planopilaris ◽  
Systemic Analysis ◽  
Scalp Diseases

<b><i>Background:</i></b> The common inflammatory scalp diseases, such as psoriasis, seborrheic dermatitis, lichen planopilaris, discoid lupus erythematosus, contact dermatitis, or pemphigus may share similar clinical features. <b><i>Objective:</i></b> To identify and systematically review the available evidence on the accuracy of trichoscopy in inflammatory scalp disorders. <b><i>Methods:</i></b> A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 58 articles were included in the analysis. <b><i>Results:</i></b> The following trichoscopy features were found to show the highest specificity for the respective diseases: in psoriasis: diffuse scaling, simple and twisted red loops, red dots and globules, and glomerular vessels; in seborrheic dermatitis: atypical vessels, thin arborizing vessels, and structureless red areas; in discoid lupus erythematosus: follicular plugs and erythema encircling follicles; in lichen planopilaris: milky red areas or fibrotic patches; in contact dermatitis: twisted red loops; in pemphigus foliaceus: white polygonal structures and serpentine vessels; in pemphigus vulgaris: red dots with whitish halo and lace-like vessels; and in dermatomyositis: lake-like vascular structures. <b><i>Limitations:</i></b> Different nomenclature and variability in parameters, which were analyzed in different studies. <b><i>Conclusion:</i></b> This systemic analysis indicates that trichoscopy may be used with high accuracy in the differential diagnosis of inflammatory scalp diseases.

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