Nosocomial Transmission of SARS-CoV-2 Involving Vaccinated Health Care Workers

COVID-19 vaccination has proven to be effective at preventing symptomatic disease but there are scarce data to fully understand whether vaccinated individuals can still behave as SARS-CoV-2 transmission vectors. Based on viral genome sequencing and detailed epidemiological interviews, we report a nosocomial transmission event involving two vaccinated health care-workers (HCWs) and four patients, one of them with fatal outcome.

Effectiveness of the WHO-Authorized COVID-19 Vaccines: A Rapid Review of Global Reports till 30 June 2021

Large clinical trials have proven the efficacy of the COVID-19 vaccine, and the number of studies about the effectiveness rapidly grew in the first half of the year after mass vaccination was administrated globally. This rapid review aims to provide evidence syntheses as a means to complement the current evidence on the vaccine effectiveness (VE) against various outcomes in real-world settings. Databases (PubMed, EMBASE, and MedRxiv) were searched up to 30 June 2021, (PROSPERO ID: 266866). A total of 39 studies were included, covering over 15 million participants from 11 nations. Among the general population being fully vaccinated, the VE against symptomatic SARS-CoV-2 infection was estimated at 89–97%, 92% (95% CI, 78–97%), and 94% (95% CI, 86–97%) for BNT162b2, ChAdOx1, and mRNA-1273, respectively. As for the protective effects against B.1.617.2-related symptomatic infection, the VE was 88% (95% CI, 85.3–90.1%) by BNT162b2 and 67.0% (95% CI, 61.3–71.8%) by ChAdOx1 after full vaccination. This review revealed a consistently high effectiveness of certain vaccines among the general population in real-world settings. However, scarce data on the major variants of SARS-CoV-2 and the shortness of the study time may limit the conclusions to the mRNA vaccines and ChAdOx1.

Comparisons of Two Approaches for Geotechnical Model Calibration with Scarce Data

Geotechnical models are usually built upon assumptions and simplifications, inevitably resulting in discrepancies between model predictions and measurements. To enhance prediction accuracy, geotechnical models are typically calibrated against measurements by bringing in additional empirical or semiempirical correction terms. Different approaches have been used in the literature to determine the optimal values of empirical parameters in the correction terms. When measured data are abundant, calibration outcomes using different approaches can be expected to be practically the same. However, if measurements are scarce or limited, calibration outcomes could differ significantly, depending largely on the adopted calibration approach. In this study, we examine two most commonly used approaches for geotechnical model calibration in the literature, namely, (1) purely data-catering (PDC) approach, and (2) root mean squared error (RMSE) method. Here, the purely data-catering approach refers to selection of empirical parameter values that minimize coefficient of variation of model factor while maintains its mean value of one, based solely on measured data. A real case of calibrating the Federal Highway Administration (FHWA) simplified facing load model for design of soil nail walls is illustrated to thoroughly elaborate the differences in practical calibration and design outcomes using the two approaches under scarce data conditions.

Nostalgia

Nostalgia is a longing for the past and the way we remember how things used to be done, including a wish for things to stay the same. Nostalgia is a central part of understanding societal responses to change because every new technology and way of doing something is, in effect, competing with nostalgia. In this chapter, I examine how nostalgia can hamper efforts at energy innovation, particularly in terms of how it blinds us to change already under way, and how memories of certain innovations can in subtle ways encourage or hinder innovation. I explore three diverse case studies about nostalgia: memories of pioneering international smart grid experiments, scarce data about off-grid households, and big infrastructure energy solutions.

COVID-19 and Diabetes

Diabetes mellitus (DM) is one of the most common comorbid conditions in persons with COVID-19 and a risk factor for poor prognosis. The reasons why COVID-19 is more severe in persons with DM are currently unknown although the scarce data available on patients with DM hospitalized because of COVID-19 show that glycemic control is inadequate. The fact that patients with COVID-19 are usually cared for by health professionals with limited experience in the management of diabetes and the need to prevent exposure to the virus may also be obstacles to glycemic control in patients with COVID-19. Effective clinical care should consider various aspects, including screening for the disease in at-risk persons, education, and monitoring of control and complications. We examine the effect of COVID-19 on DM in terms of glycemic control and the restrictions arising from the pandemic and assess management of diabetes and drug therapy in various scenarios, taking into account factors such as physical exercise, diet, blood glucose monitoring, and pharmacological treatment. Specific attention is given to patients who have been admitted to hospital and critically ill patients. Finally, we consider the role of telemedicine in the management of DM patients with COVID-19 during the pandemic and in the future.

Briefbeförderung des Ordens in Livland. Mit vorläufigen statistischen Bewertung

Delivery of Letters in the Teutonic Order in Livonia. With a preliminary statistical analysisThis contribution is on the organization and efficiency of the delivery of letters in the Teutonic Order in Livonia. Firstly, the scarce data on couriers is presented. Main part of the contribution is discussing the phenomenon of registration of time (hour) and place in some of the stations on the delivery routes of letters. This method, used extensively also in Prussia, was most likely introduced in Livonia in the beginning of the 15th century. It was used in case of most urgent letters and was first of all meant to monitor the efficiency of delivery. The majority of the places of registration of time are in the territory of the Order, but there are also some exceptions, when this was done in episcopal castles or manors. High number of letters of the Masters of the Teutonic Order in Tallinn City Archives is also allowing some preliminary statistical analysis, how the space and time was mastered on the route Riga-Wenden-Reval. It appears, that although the letters were ordered to be carried day and night, the calculated average speed is so low, that there were obviously made also some stops for rest on the road.

Prevalence and factors associated with lupus nephritis in Venezuelan patients

There are scarce data on lupus nephritis from single Latin American countries. We have assessed the prevalence and factors associated with lupus nephritis in a sample of Venezuelan patients with systemic lupus erythematosus (SLE).

Ertapenem for treatment of non-severe bacteremic urinary-tract infections due to ESBL-producing Enterobacterales in kidney transplant recipients: a propensity score and DOOR-based analysis.

There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to ESBL-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with non-severe bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem vs. meropenem and clinical cure at day 14 (principal outcome) was studied by logistic regression. Propensity score-matched and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29, 95% CI 0.51-3.22; P=0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14: 1.18, 95%CI 0.43-3.29; P=0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95%CI, 40.4-59.1%) when hospital stay was considered. It ranged from 59-67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost were considered besides outcomes. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat non-severe B-UTI due to ESBL-E in KT recipients and may have some advantages.