Matrix metalloproteinase‐2 mediates ribosomal RNA transcription by cleaving nucleolar histones

Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones

10.1101/2020.02.21.958280 ◽

2020 ◽

Author(s):

Mohammad A.M. Ali ◽

Javier A. Garcia-Vilas ◽

Christopher R. Cromwell ◽

Basil P. Hubbard ◽

Michael J. Hendzel ◽

...

Keyword(s):

Cell Proliferation ◽

Matrix Metalloproteinase ◽

Ribosomal Rna ◽

Ribosome Biogenesis ◽

Histone H3 ◽

Epigenetic Mechanism ◽

Matrix Metalloproteinase 2 ◽

Rrna Gene ◽

Rrna Transcription ◽

Genes Encoding

AbstractCell proliferation and survival require continuous ribosome biogenesis and protein synthesis. Genes encoding ribosomal RNA (rRNA) are physically located in a specialized substructure within the nucleus known as the nucleolus, which has a central role in the biogenesis of ribosomes. Matrix metalloproteinase-2 (MMP-2) was previously detected in the nucleus. However, its role there is elusive. Herein we report that MMP-2 resides within the nucleolus to regulate rRNA transcription. MMP-2 is enriched at the promoter region of rRNA gene repeats and its inhibition downregulates pre-rRNA transcription. The N-terminal tail of histone H3 is clipped by MMP-2 in the nucleolus and is associated with increased rRNA transcription. Knocking down/out MMP-2 or inhibiting its activity prevents histone H3 cleavage and reduces both rRNA transcription and cell proliferation. In addition to the known extracellular roles of MMP-2 in tumor growth, our data reveal an epigenetic mechanism whereby intranucleolar MMP-2 regulates cell proliferation through histone proteolysis and facilitation of rRNA transcription.

W01.18 Matrix metalloproteinase 2 and 9 evaluation in different patient groups with or without diabetes

Atherosclerosis ◽

10.1016/s0021-9150(04)90018-4 ◽

2004 ◽

Vol 5 (1) ◽

pp. 5

Author(s):

G DEROSA

Keyword(s):

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 2 ◽

Patient Groups

Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor-Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways

Yearbook of Pathology and Laboratory Medicine ◽

10.1016/s1077-9108(08)70678-9 ◽

2008 ◽

Vol 2008 ◽

pp. 231-233

Author(s):

C. Horbinski

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Matrix Metalloproteinase ◽

Growth Factor Receptor ◽

Glioma Cells ◽

Akt Signaling ◽

Matrix Metalloproteinase 2 ◽

Phosphatidylinositol 3 Kinase ◽

Epidermal Growth

Dinstinct pro-inflammatory cytokines regulate matrix metalloproteinase-2 and 9 levels in congestive heart failure

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(08)60384-7 ◽

2008 ◽

Vol 7 ◽

pp. 136-136

Author(s):

I ANDREOU ◽

D TOUSOULIS ◽

C VASILIADOU ◽

C TENTOLOURIS ◽

I KOTROGIANNIS ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Matrix Metalloproteinase ◽

Inflammatory Cytokines ◽

Matrix Metalloproteinase 2 ◽

Pro Inflammatory Cytokines

Inhibitory effect of panduratin A on the expression of matrix metalloproteinase-2 in Porphyromonas gingivalis supernatant-treated human gingival fibroblasts

Planta Medica ◽

10.1055/s-0029-1234981 ◽

2009 ◽

Vol 75 (09) ◽

Keyword(s):

Matrix Metalloproteinase ◽

Porphyromonas Gingivalis ◽

Inhibitory Effect ◽

Human Gingival Fibroblasts ◽

Matrix Metalloproteinase 2 ◽

Gingival Fibroblasts ◽

Panduratin A

The upregulation of matrix metalloproteinase -2 and -9 genes caused by resistin in human chondrocytes

Acta Medica Anatolia ◽

10.15824/actamedica.89675 ◽

2014 ◽

Vol 2 (1) ◽

pp. 19 ◽

Cited By ~ 1

Author(s):

Kürşat Oğuz Yaykaşlı ◽

Mustafa Doğan ◽

Ertuğrul Kaya ◽

Mustafa Özşahin ◽

Emine Yaykaşlı ◽

...

Keyword(s):

Matrix Metalloproteinase ◽

Human Chondrocytes ◽

Matrix Metalloproteinase 2

Faculty Opinions recommendation of Proteolysis of cell-surface tissue transglutaminase by matrix metalloproteinase-2 contributes to the adhesive defect and matrix abnormalities in thrombospondin-2-null fibroblasts and mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1028943.342441 ◽

2005 ◽

Author(s):

Helen Gruber

Keyword(s):

Cell Surface ◽

Matrix Metalloproteinase ◽

Tissue Transglutaminase ◽

Matrix Metalloproteinase 2

Faculty Opinions recommendation of Heavy smoking before coronary surgical procedures affects the native matrix metalloproteinase-2 and matrix metalloproteinase-9 gene expression in saphenous vein conduits.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718001896.793475279 ◽

2013 ◽

Author(s):

Andreas Deussen

Keyword(s):

Gene Expression ◽

Matrix Metalloproteinase ◽

Surgical Procedures ◽

Saphenous Vein ◽

Matrix Metalloproteinase 9 ◽

Matrix Metalloproteinase 2 ◽

Heavy Smoking ◽

Metalloproteinase 9

Faculty Opinions recommendation of Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718288683.793540036 ◽

2017 ◽

Author(s):

Cheng-Hock Toh

Keyword(s):

Systemic Lupus Erythematosus ◽

Endothelial Dysfunction ◽

Matrix Metalloproteinase ◽

Lupus Erythematosus ◽

Neutrophil Extracellular Traps ◽

Matrix Metalloproteinase 2 ◽

Systemic Lupus ◽

Extracellular Traps

Extracellular Matrix Regulations of Membrane Type 1-Matrix Metalloproteinasis (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts

10.21236/ada395355 ◽

2000 ◽

Author(s):

Sonia Hernandez-Barrantes ◽

Rafael Fridman

Keyword(s):

Extracellular Matrix ◽

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 2 ◽

Human Breast ◽

Membrane Type ◽

Breast Fibroblasts