Identification of prognostic factors for activities of daily living in elderly patients after hospitalization for acute infectious disease in Japan: A 6-month follow-up study

2017 ◽  
Vol 18 (4) ◽  
pp. 615-622 ◽  
Author(s):  
Ryohei Goto ◽  
Hiroki Watanabe ◽  
Junji Haruta ◽  
Madoka Tsutsumi ◽  
Shoji Yokoya ◽  
...  
2006 ◽  
Vol 18 (5) ◽  
pp. 352-358 ◽  
Author(s):  
Maria Victoria Zunzunegui ◽  
Olivier Nunez ◽  
Maria Durban ◽  
María-Jesús García de Yébenes ◽  
Ángel Otero

2019 ◽  
Vol 32 (6) ◽  
pp. 741-751 ◽  
Author(s):  
Toni Saari ◽  
Ilona Hallikainen ◽  
Taina Hintsa ◽  
Anne M. Koivisto

ABSTRACTBackground:Neuropsychiatric symptoms (NPSs) in Alzheimer’s disease (AD) are related to activities of daily living (ADLs), but longitudinal studies are sparse.Objectives:We investigated which NPSs were related to decline in instrumental ADLs (IADLs) and basic ADLs (BADLs) in a 5-year follow-up of individuals with AD.Methods:ALSOVA 5-year follow-up study data of 236 individuals with very mild or mild AD at baseline and their caregiver were analyzed. IADLs and BADLs were assessed with Alzheimer’s Disease Cooperative Study ADL inventory, and NPSs with Neuropsychiatric Inventory at annual follow-up visits. Generalized estimating equations (GEEs) were used for longitudinal data analysis, and NPS–ADL networks were estimated to demonstrate symptom interactions.Results:Apathy [rate ratio (RR) 1.23, 95% CI 1.06–1.44, p = 0.007], aberrant motor behavior (RR 1.24, 95% CI 1.07–1.44, p = 0.005), and appetite disturbances (RR 1.22, 95% CI 1.06–1.41, p = 0.005) were related to impairment in BADLs, and the same symptoms (RR 1.13, 95% CI 1.07–1.21, p < 0.001; RR 1.13, 95% CI 1.07–1.20, p < 0.001; RR 1.14; 95% CI 1.08–1.21, p < 0.001, for apathy, aberrant motor behavior, and appetite disturbances, respectively), in addition to delusions (RR 1.09, 95% CI 1.03–1.15, p = 0.004), were related to IADL impairment. Symptom networks varied at different time points.Conclusion:As AD progresses, common (apathy) and uncommon NPSs (aberrant motor behavior, appetite disturbances, delusions) seem to be related to ADLs through various symptom interactions. Previous literature suggests that frontal pathology could underlie these relationships.


PM&R ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. S182
Author(s):  
Chia-Ling Chen ◽  
Chung-Yao Chen ◽  
Hsieh-Ching Chen ◽  
Chia-Ying Chung ◽  
Wen-chung Tsai ◽  
...  

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1310-1310 ◽  
Author(s):  
Ulrich Wedding ◽  
Friedemann Honecker ◽  
Klaus Rettig ◽  
Susanne Huschens ◽  
Carsten Bokemeyer

Abstract Background: The internet based registry of IN-GHOα prospectively collects data of elderly cancer patients (pts) 370 yrs. We report data from 450 pts with hematological neoplasia (HE) out of 1580 cancer patients registered currently. To gain more insight into feasibility of treatment in elderly patients, results of a comprehensive geriatric assessment (CGA), physicians’ and pts’ judgement of fitness, and outcome measures were studied. Methods: Besides demographic data, activities of daily living (ADL), instrumental activities of daily living (IADL), Karnofsky-Performance-Statuts (KPS), co-morbidity (Charlson score), medication (number of drugs not related the HE treatment), mobility (Timed-Up&Go-Test), cognition (MMSE), and depression (SCID screening) results were collected. Age, results of CGA, physicians’ rating (fit vs. compromised vs. frail) and pts’ self rated fitness (lickert scale for 1= very fit to 6 very unfit) for treatment were analysed for their association with death. Follow up assessment was scheduled 8–12 weeks and 5–7 months after inclusion. Results: 450 patients, mean age 77.7 years (SD 5.7; range 69–97), 43.3%male, were included. Main diagnoses were aggressive lymphoma n = 135 (30%), chronic lymphocytic leukemia n = 66 (14.7), multiple myeloma n = 54, acute myeloid leukemia n = 27 (6.0%), and others. Physicians rating of patientś fitness for treatment: fit 54.4%, compromised 39.1%, frail 5.5%. Patients rating of patientś fitness for treatment: 1 = 19.6%, 2 = 31.8%, 3 = 25.1%, 4 = 13.6%, 5 = 3.8%, 6 = 1.1%. During follow up (median 178 days), 98 pts (21.8%) patients died: mean age (77.5 vs. 78.5; p=0.219), mean BMI (25.6 vs. 25.3; p=0.228), mean Charlson-score (2.0 vs. 2.3; p=0.28) and mean number of drugs (4.0 vs. 4.2; p=0.14) were not associated with death. However significantly associated with death during follow up were mean ADL score (94.0 vs. 87.4; p=0.047), mean IADL score (7.1 vs. 6.3; p&lt;0.001), mean KPS score (83 vs. 74; p=0.001), mean MMSE score (26 vs. 24; p=0.03), categorical Timed-Up&Go-Test (&lt; 10 sec 18% vs. &gt; 20 sec 38%; p&lt;0.001), categorical SCID screening (no depression 18% vs. depression 31%; p&lt;0.001), physicianś rating of fitness (fit 18.8%, compromised 21.6%, frail 52.0%; p=0.001) and patientś rating of fitness (lickert scale 2.3 vs. 3.4; p&lt;0.001). Conclusion: Patients characteristics as assessed by CGA and not age are associated with death in elderly patients with hematological malignancies. Results of CGA should be validated in treatment algorithm for this population.


2015 ◽  
Vol 50 (2) ◽  
pp. 237-246 ◽  
Author(s):  
Po-Wen Ku ◽  
Kenneth R. Fox ◽  
Paul A. Gardiner ◽  
Li-Jung Chen

2013 ◽  
Vol 48 (4) ◽  
pp. 437-443 ◽  
Author(s):  
Marjolein E.M. den Ouden ◽  
Marieke J. Schuurmans ◽  
Sigrid Mueller-Schotte ◽  
Y.T. van der Schouw

Sign in / Sign up

Export Citation Format

Share Document