Genetic analysis and clinicopathological features of ALK -rearranged renal cell carcinoma in a large series of resected Chinese renal cell carcinoma patients and literature review

2017 ◽  
Vol 71 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Wenjuan Yu ◽  
Yuewei Wang ◽  
Yanxia Jiang ◽  
Wei Zhang ◽  
Yujun Li
2016 ◽  
Vol 33 (2) ◽  
pp. 68-73
Author(s):  
Pedro Miguel Baltazar ◽  
Ana Meirinha ◽  
Raquel João ◽  
João Magalhães Pina ◽  
Hugo Pinheiro ◽  
...  

2009 ◽  
Vol 1 (2) ◽  
pp. 16
Author(s):  
Tobe Samuel Momah ◽  
Dhanan Etwaru ◽  
Phillip Xiao ◽  
Vasantha Kondamudi

2020 ◽  
Author(s):  
Naoto Nishii ◽  
Hiroaki Shimamoto ◽  
Toshimitsu Ohsako ◽  
Misaki Yokokawa ◽  
Yuriko Sato ◽  
...  

Abstract Background: Metastasis of renal cell carcinoma (RCC) to the oral cavity is rare. Given the poor prognosis of metastatic RCC, treatment choice is difficult. Here, we report a case of RCC metastasis to the maxillary bone, and provide a detailed literature review regarding the patient characteristics, treatments and outcomes of RCC metastasis to the oral cavity.Case presentation: An 89-year-old Japanese man presented with an 8 × 8-mm granulomatous tumor with palpable pulsation in the left upper gingiva, which had been clinically suspected as an arteriovenous malformation. The patient had undergone left nephrectomy for clear cell carcinoma 7 years prior. Pulmonary metastasis had appeared 3 years later. The patient underwent tumor resection of the maxilla after intravascular embolization, and the tumor was histopathologically diagnosed as a metastasis of clear cell RCC to the maxillary bone. Seventeen months after surgery, he died because of pulmonary metastasis without evidence of recurrence in the oral cavity.Conclusion: Our literature review reveals that oral metastatic lesions of renal cancer often exhibit rapid enlargement and cause severe symptoms, such as dysphagia and bleeding. Although oral metastasis of RCC has a poor prognosis due to the presence of concurrent disseminated metastases, surgical therapy may be recommended because of its high local control rate and ability to maintain quality of life.


2018 ◽  
Vol 46 (8) ◽  
pp. 3422-3426 ◽  
Author(s):  
Ercan Yilmaz ◽  
Fatih Oguz ◽  
Gorkem Tuncay ◽  
Rauf Melekoglu ◽  
Ali Beytur ◽  
...  

Diagnosing cancer during pregnancy is uncommon. Although pregnancies with concomitant malignancies have been reported, urological tumours are possibly the most rarely identified tumours during pregnancy. Renal cell carcinoma appears to be the most common urological malignancy during pregnancy. In this case report, we discuss successful management of a patient who was diagnosed with renal cell carcinoma during the antenatal period.


2019 ◽  
Author(s):  
hualin song ◽  
Peng xiang ◽  
Zhifu liu ◽  
shuai hu ◽  
Jie Jin

Abstract Background: There are a mass of studies declared the prognostic significance of C-reactive protein/albumin ratio (CRP/Alb) in renal cell carcinoma (RCC). Nevertheless, these works are controversial. In our study, we investigate the expression of CRP/Alb in RCC and its role in prognosis and clinicopathological features. Methods: The PubMed, Embase and Cochrane databases were searched systematically for correlative articles published before August 1, 2019. Hazard ratios (HRs) and 95% confidence intervals (CIs) were determined according to eligible studies. And we use fixed and random effects models to calculate on the basis of heterogeneity. Results: Six relevant studies were identified in this study, 1959 participants included in total. Our results showed that CRP/Alb was related to poor overall survival (HR=1.86, 95% CI: 1.56-2.21). In addition, CRP/Alb was also associated with tumor stage (OR=3.29, 95% CI: 1.66-6.50), lymph node involvement (OR=3.76, 95% CI: 2.57-5.51), metastasis (OR=5.69, 95% CI: 2.40-13.51), Fuhrman nuclear grade (OR=4.21, 95% CI: 3.14-5.64), pTNM (OR=4.34, 95% CI: 1.94-9.70) and tumor size (WMD=2.26, 95% CI: 1.86–2.67). However, CRP/Alb was not associated with necrosis. Conclusion: Our study illustrates that the higher CRP/Alb expression was correlated with poorer prognosis and more advanced clinicopathological features in RCC patients. High CRP/Alb expression may act as a valuable predictive biomarker for poor prognosis in RCC patients.


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