scholarly journals In search of lost time: Enhancers as modulators of timing in lymphocyte development and differentiation

2021 ◽  
Author(s):  
Jonathan M. Chu ◽  
Nicholas A. Pease ◽  
Hao Yuan Kueh
Keyword(s):  
Lymphocyte Development ◽  
Development And Differentiation ◽  
Lost Time

Residual lymphocyte development in γc deficient mice is not due to TSLP

1997 ◽  
Vol 56 (1-3) ◽  
pp. 276
Author(s):  
C Voßhenrich
Keyword(s):  
Lymphocyte Development ◽  
Deficient Mice

Sculpting in Lost Time: The Fragmentation of Bruno Schulz's The Street of Crocodiles in Jonathan Safran Foer's Tree of Codes

2013 ◽  
Vol 10 (supplement) ◽  
pp. 75-90
Author(s):  
James Randall
Keyword(s):  
Lost Time

Time Lost, Time Regained: Billy Wilder's The Private Life of Sherlock Holmes

2020 ◽  
Vol 1 (2) ◽  
pp. 189-202
Author(s):  
Laura Marcus
Keyword(s):  
Private Life ◽  
Sherlock Holmes ◽  
History Of ◽  
Part Structure ◽  
Lost Time

This article discusses Billy Wilder's 1970 film The Private Life of Sherlock Holmes, which, though not enthusiastically received by audiences at the time, has subsequently become a work highly valued by critics and cineastes. Radically cut from its original four-part structure by the studio, it has come to be perceived as a film about loss. This relates both to its themes – suppressed love, the vanished world of Holmes and Watson – and to the history of the film itself, whose missing episodes exist only in fragmentary form. The first part of the essay looks at the ways in which the film constructs an image of Sherlock Holmes (played by Robert Stephen), with a focus on the question of his sexuality, while the second part turns to the ways in which the film became an ‘obsession’ for one writer in particular, the novelist Jonathan Coe.

Metaphor's Lost Time: Notes on the New Translations of Proust

2005 ◽  
Vol 44 (2) ◽  
pp. 31-41 ◽  
Author(s):  
Michael O'Sullivan
Keyword(s):  
Lost Time

‘In search of lost time’, ‘friendship and archaeology’: a personal reminiscence of Ludovic Mann, Joseph Harrison Maxwell and George Applebey – my father

2020 ◽  
Vol 42 (Supplement) ◽  
pp. 7-22
Author(s):  
George Applebey
Keyword(s):  
Twentieth Century ◽  
Rock Art ◽  
Personal Reminiscence ◽  
Lost Time

In this paper, I will reflect on my personal memories of Ludovic Mann, friend and mentor to my late father George Applebey, whose archaeological career is also a focus of the paper. They both worked together on Mann's most famous excavations at Knappers Farm, and the nearby painting of the Cochno Stone rock-art panel. However, these are only two examples of their long-term collaboration and friendship, and this paper will explore the broader context within which they worked. This will include consideration of other collaborators, such as J Harrison Maxwell, part of the ‘Ludovic Group’ in the first half of the twentieth century. The important role that all three men played in the development of Scottish archaeology is noted. The paper concludes with developments following Mann's death in 1955 including George Applebey's emergence as a noted amateur archaeologist in his own right, and the fate of the Mann and Applebey collections.

Le théâtre, image de l’esthétique proustienne

2020 ◽  
Vol 65 (2) ◽  
pp. 189-202
Author(s):  
Yvonne Goga
Keyword(s):  
Important Place ◽  
Complex Theory ◽  
Artistic Conception ◽  
Lost Time

"Theatre as an Image of Proust’s Aesthetic. In In Search of Lost Time, theatre holds an important place, especially in the first three volumes. Being part of the frequent activities of society, it gives many occasions to the narrator to express his thoughts about theatre shows. Our aim will be to demonstrate that those thoughts are one of the ways used by Proust to bring out his complex theory about novelistic creation – a theory which shows to what extent art’s aim is to access the essence of things through sensitive experience. Keywords: art, theatre show, sensitive experience, essence, artistic conception."

Le premier moment de l’art dans À la recherche du temps perdu de Marcel Proust – une « leçon d’idéalisme » ?

2020 ◽  
pp. 25-40
Author(s):  
Larisa Botnari
Keyword(s):  
Essential Role ◽  
Marcel Proust ◽  
The Self ◽  
Philosophy Of Art ◽  
The Novel ◽  
Philosophical Interpretation ◽  
German Philosopher ◽  
Lost Time ◽  
Aesthetic Thinking

Although very famous, some key moments of the novel In Search of Lost Time, such as those of the madeleine or the uneven pavement, often remain enigmatic for the reader. Our article attempts to formulate a possible philosophical interpretation of the narrator's experiences during these scenes, through a confrontation of the Proustian text with the ideas found in the System of Transcendental Idealism (1800) of the German philosopher F. W. J. Schelling. We thus try to highlight the essential role of the self in Marcel Proust's aesthetic thinking, by showing that the mysterious happiness felt by the narrator, and from which the project of creating a work of art is ultimately born, is similar to the experiences of pure self-consciousness evoked and analyzed by Schellingian philosophy of art.

The Role of Retinoblastoma Protein in Cell Cycle Regulation: An Updated Review

2021 ◽  
Vol 20 ◽  
Author(s):  
Rabih Roufayel ◽  
Rabih Mezher ◽  
Kenneth B. Storey
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Transcription Factors ◽  
Cell Cycle Control ◽  
Expression Of Genes ◽  
E2f Transcription Factor ◽  
Cellular Energetics ◽  
Development And Differentiation ◽  
E2f Transcription Factors ◽  
Rb Phosphorylation

: Selected transcription factors have critical roles to play in organism survival by regulating the expression of genes that control the adaptations needed to handle stress conditions. The retinoblastoma (Rb) protein coupled with the E2F transcription factor family was demonstrated to have roles in controlling the cell cycle during freezing and associated environmental stresses (anoxia, dehydration). Rb phosphorylation or acetylation at different sites provide a mechanism for repressing cell proliferation that is under the control of E2F transcription factors in animals facing stresses that disrupt cellular energetics or cell volume controls. Other central regulators of the cell cycle including Cyclins, Cyclin dependent kinases (Cdks), and checkpoint proteins detect DNA damage or any improper replication, blocking further progression of cell cycle and interrupting cell proliferation. This review provides an insight into the molecular regulatory mechanisms of cell cycle control, focusing on Rb-E2F along with Cyclin-Cdk complexes typically involved in development and differentiation that need to be regulated in order to survive extreme cellular stress.

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