Indoor microbiome and risk of lower respiratory tract infections among children under‐five years: A meta‐analysis

Indoor Air ◽  
2020 ◽  
Vol 30 (5) ◽  
pp. 795-804
Author(s):  
Adekunle G. Fakunle ◽  
Nkosana Jafta ◽  
Akinkunmi P. Okekunle ◽  
Rajen N. Naidoo
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Meta Analysis ◽  
Lower Respiratory Tract Infections ◽  
Children Under Five ◽  
Under Five ◽  
Indoor Microbiome ◽  
Tract Infections

scholarly journals Home Assessment of Indoor Microbiome (HAIM) in Relation to Lower Respiratory Tract Infections among Under-Five Children in Ibadan, Nigeria: The Study Protocol

2020 ◽  
Vol 17 (6) ◽  
pp. 1857 ◽  
Author(s):  
Adekunle G. Fakunle ◽  
Babatunde Olusola ◽  
Nkosana Jafta ◽  
Adedayo Faneye ◽  
Dick Heederik ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Lower Respiratory Tract Infections ◽  
Community Based ◽  
Under Five ◽  
Under Five Children ◽  
Indoor Microbiome ◽  
Tract Infections ◽  
Ibadan Nigeria

The association between household air pollution and lower respiratory tract infections (LRTI) among children under five years of age has been well documented; however, the extent to which the microbiome within the indoor environment contributes to this association is uncertain. The home assessment of indoor microbiome (HAIM) study seeks to assess the abundance of indoor microbiota (IM) in the homes of under-five children (U-5Cs) with and without LRTI. HAIM is a hospital- and community-based study involving 200 cases and 200 controls recruited from three children’s hospitals in Ibadan, Nigeria. Cases will be hospital-based patients with LRTI confirmed by a pediatrician, while controls will be community-based participants, matched to cases on the basis of sex, geographical location, and age (±3 months) without LRTI. The abundance of IM in houses of cases and controls will be investigated using active and passive air sampling techniques and analyzed by qualitative detection of bacterial 16SrRNA gene (V3–V4), fungal ITS1 region, and viral RNA sequencing. HAIM is expected to elucidate the relationship between exposure to IM and incidence of LRTI among U-5Cs and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of LRTI on the subcontinent.

scholarly journals The burden and etiology of lower respiratory tract infections in children under five years of age in Indonesia

2021 ◽  
Vol 15 (05) ◽  
pp. 603-614
Author(s):  
Vincentia Rizke Ciptaningtyas ◽  
Quirijn De Mast ◽  
Marinus Isaäk De Jonge
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Case Fatality ◽  
Invasive Disease ◽  
Upper Respiratory Tract ◽  
Lower Respiratory Tract Infections ◽  
Children Under Five ◽  
Under Five ◽  
Tract Infections

Introduction: Lower respiratory tract infections (LRTI) are a substantial threat for children worldwide. Currently, there is a lack of knowledge about the burden and etiology of LRTI in children under five years of age in Indonesia. Methodology: We have systematically searched the available English and Indonesian scientific literature to review and summarize data on LRTI and LRTI-associated invasive disease, and bacterial carriage in the upper respiratory tract in children under five years of age in Indonesia. Results: Overall, data on the burden and etiology of LRTI in children under five years of age in Indonesia is very limited. The data are primarily collected in Java. Data from other parts of Indonesia, including Sumatra, Kalimantan, and Sulawesi, are scarce. The case fatality rate (CFR) of LRTI in children under five years of age in Indonesia was 0.11%. Influenza was the most commonly reported viral etiological agent of LRTI in children under five years of age in Indonesia. Klebsiella pneumoniae was the most frequently reported bacterial agent of LRTI. Streptococcus pneumoniae showed the highest carriage rates. Conclusions: Surveillance and diagnostic studies are urgently needed and should be conducted in different parts of Indonesia to improve insight in the burden and etiology of LRTI in Indonesia. These data are pivotal to increase the effectiveness of public health strategies, including vaccination and prevention of antimicrobial resistance.

scholarly journals Prevalence of respiratory bacterial infections in people with lower respiratory tract infections in Africa: the BARIAFRICA systematic review and meta-analysis protocol

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e023592
Author(s):  
Serges Tchatchouang ◽  
Jean Joel Bigna ◽  
Ariane Nzouankeu ◽  
Marie-Christine Fonkoua ◽  
Jobert Richie Nansseu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Bacterial Infections ◽  
Respiratory Tract Infections ◽  
Meta Analysis ◽  
Health Concern ◽  
Published Data ◽  
Lower Respiratory Tract Infections ◽  
Tract Infections

IntroductionThe burden of lower respiratory tract infections (LRTIs) is a substantial public health concern. However, the epidemiology of LRTI and its bacterial aetiologies are poorly characterised, particularly in the African continent. Providing accurate data can help design cost-effective interventions to curb the burden of respiratory infections in Africa. Therefore, the aim of this systematic review and meta-analysis will be to determine the prevalence of respiratory Bacterial Aetiologies in people with low Respiratory tract Infections in Africa (BARIAFRICA) and associated factors.Methods and analysisWe will search PubMed, EMBASE, Web of Science, African Journals Online, Cumulative Index to Nursing and Allied Health Literature, and Global Index Medicus to identify studies that reported the prevalence (of enough data to compute this estimate) of respiratory bacterial infections in people with LRTIs in Africa from 1 January 2000 to 31 March 2018, without any linguistic restrictions. Study selection, data extraction and risk of bias assessment will be conducted independently by two investigators. Heterogeneity will be evaluated using the χ² test on Cochran’s Q statistic and quantified with H and I² statistics. Prevalence will be pooled using a random-effect meta-analysis model. Subgroup and meta-regression analyses will be used to identify sources of heterogeneity of prevalence estimates. This study will be reported according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Ethics and disseminationSince this study will be based on published data, it does not require ethical approval. This systematic review and meta-analysis is intended to serve as a basis for determining the burden of LRTIs, for identifying data gaps and for guiding future investigations in Africa. The final report will be published in peer-reviewed journals, presented in conferences and submitted to relevant health policy makers.PROSPERO registration numberCRD42018092359.

Sign in / Sign up

Export Citation Format

Share Document