Association between oral clefts and periodontal clinical measures: meta‐analysis

2021 ◽  
Author(s):  
Tamer Marzouk ◽  
Mostafa Youssef ◽  
Alexandra Tsigarida ◽  
Christy McKinney ◽  
Cynthia Wong ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Oral Clefts ◽  
Clinical Measures

SYSTEMATIC REVIEW AND META-ANALYSIS SHOW POTENTIAL GENETIC MARKERS FOR NONSYNDROMIC ORAL CLEFTS IN BRAZILIANS

2020 ◽  
Vol 130 (3) ◽  
pp. e239
Author(s):  
RENATO ASSIS MACHADO ◽  
ISABELA PORTO DE TOLEDO ◽  
HERCíLIO MARTELLI-JÚNIOR ◽  
SILVIA REGINA REIS ◽  
ELIETE NEVES SILVA GUERRA ◽  
...  
Keyword(s):  
Systematic Review ◽  
Genetic Markers ◽  
Meta Analysis ◽  
Oral Clefts

scholarly journals The ability of clinical balance measures to identify falls risk in multiple sclerosis: a systematic review and meta-analysis

2017 ◽  
Vol 32 (5) ◽  
pp. 571-582 ◽  
Author(s):  
Gillian Quinn ◽  
Laura Comber ◽  
Rose Galvin ◽  
Susan Coote
Keyword(s):  
Multiple Sclerosis ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Predictive Ability ◽  
Timed Up And Go ◽  
Discriminative Ability ◽  
Cross Sectional ◽  
Falls Risk ◽  
Clinical Measures

Objective: To determine the ability of clinical measures of balance to distinguish fallers from non-fallers and to determine their predictive validity in identifying those at risk of falls. Data sources: AMED, CINAHL, Medline, Scopus, PubMed Central and Google Scholar. First search: July 2015. Final search: October 2017. Review methods: Inclusion criteria were studies of adults with a definite multiple sclerosis diagnosis, a clinical balance assessment and method of falls recording. Data were extracted independently by two reviewers. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 scale and the modified Newcastle–Ottawa Quality Assessment Scale. Statistical analysis was conducted for the cross-sectional studies using Review Manager 5. The mean difference with 95% confidence interval in balance outcomes between fallers and non-fallers was used as the mode of analysis. Results: We included 33 studies (19 cross-sectional, 5 randomised controlled trials, 9 prospective) with a total of 3901 participants, of which 1917 (49%) were classified as fallers. The balance measures most commonly reported were the Berg Balance Scale, Timed Up and Go and Falls Efficacy Scale International. Meta-analysis demonstrated fallers perform significantly worse than non-fallers on all measures analysed except the Timed Up and Go Cognitive ( p < 0.05), but discriminative ability of the measures is commonly not reported. Of those reported, the Activities-specific Balance Confidence Scale had the highest area under the receiver operating characteristic curve value (0.92), but without reporting corresponding measures of clinical utility. Conclusion: Clinical measures of balance differ significantly between fallers and non-fallers but have poor predictive ability for falls risk in people with multiple sclerosis.

Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis

2012 ◽  
Vol 40 (1) ◽  
pp. 3-14 ◽  
Author(s):  
Ana Paula Corrêa de Queiroz Herkrath ◽  
Fernando José Herkrath ◽  
Maria Augusta Bessa Rebelo ◽  
Mario Vianna Vettore
Keyword(s):  
Risk Factor ◽  
Meta Analysis ◽  
Parental Age ◽  
Oral Clefts

scholarly journals Folic acid–containing supplement consumption during pregnancy and risk for oral clefts: A meta-analysis

2007 ◽  
Vol 79 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Rachel L. Badovinac ◽  
Martha M. Werler ◽  
Paige L. Williams ◽  
Karl T. Kelsey ◽  
Catherine Hayes
Keyword(s):  
Folic Acid ◽  
Meta Analysis ◽  
Oral Clefts

Prevalence of Dental Anomalies in Nonsyndromic Individuals with Cleft Lip and Palate: A Systematic Review and Meta-analysis

2012 ◽  
Vol 49 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Patricia Nivoloni Tannure ◽  
Cristiana Aroeira G.R. Oliveira ◽  
Lucianne Copie Maia ◽  
Alexandre R. Vieira ◽  
José Mauro Granjeiro ◽  
...  
Keyword(s):  
Random Effects ◽  
Fixed Effects ◽  
Cleft Lip And Palate ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Permanent Teeth ◽  
Cochrane Library ◽  
Tooth Agenesis ◽  
Dental Anomalies ◽  
Oral Clefts

Objective To assess whether individuals born with nonsyndromic oral clefts display a higher frequency of dental anomalies. Design A search of MEDLINE, BIREME, OVID ALL EMB Reviews, and The Cochrane Library was conducted. The methodologic quality of the papers selected was assessed and scored. Papers reporting observational controlled studies of nonsyndromic forms of oral cleft matched for dental anomalies in primary and/or permanent teeth were included without language restrictions. Eligible studies were scored as “A”—low risk of bias, “B”—moderate risk of bias, or “C”—high risk of bias and poor quality. Fixed and random effects models were used to aggregate individual odds ratios (OR) and to derive pooled estimates and 95% confidence intervals. Results Six studies fulfilled our selection criteria and were included in the meta-analysis. Three distinct subgroup analyses were carried out in terms of dental anomalies. In the tooth agenesis meta-analysis, a random effects model was used because of heterogeneity and showed a significant association between tooth agenesis and oral clefts (OR = 12.31; 95% confidence interval [CI] = 3.75 to 40.36). In the remaining analyses, the fixed effects model revealed a positive association between supernumerary (OR = 4.99; 95% CI, 2.58 to 9.64) and crown morphologic abnormalities (OR = 5.69; 95% CI, 3.96 to 8.19) with oral clefts. Most included studies were of low to moderate quality. Conclusion Although general limitations in study design were observed, the evidence suggests that a higher number of dental anomalies in the permanent dentition are noted in individuals born with oral clefts.

Association of AXIN2 and CDH1 genes polymorphism with non syndromic Oral Clefts: A meta-analysis

Gene Reports ◽  
2021 ◽  
pp. 101424
Author(s):  
Paria Motahari
Keyword(s):  
Meta Analysis ◽  
Oral Clefts

scholarly journals Oral clefts and periodontal clinical measures

BDJ ◽  
2021 ◽  
Vol 231 (10) ◽  
pp. 639-639
Keyword(s):  
Oral Clefts ◽  
Clinical Measures

Maternal Cigarette Smoking and Oral Clefts: A Meta-analysis

1997 ◽  
Vol 34 (3) ◽  
pp. 206-210 ◽  
Author(s):  
Diego F. Wyszynski ◽  
David L. Duffy ◽  
Terri H. Beaty
Keyword(s):  
Cigarette Smoking ◽  
Meta Analysis ◽  
Oral Clefts ◽  
Maternal Cigarette Smoking

Birth order and oral clefts: A meta analysis

Teratology ◽  
2002 ◽  
Vol 66 (5) ◽  
pp. 209-216 ◽  
Author(s):  
Alexandre R. Vieira ◽  
I�da M. Orioli
Keyword(s):  
Birth Order ◽  
Meta Analysis ◽  
Oral Clefts

Oral Clefts, Maternal Smoking, and TGFA: A Meta-Analysis of Gene-Environment Interaction

2005 ◽  
Vol 42 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Joanna S. Zeiger ◽  
Terri H. Beaty ◽  
Kung-Yee Liang
Keyword(s):  
Logistic Regression ◽  
Maternal Smoking ◽  
Meta Analysis ◽  
Case Control ◽  
Environment Interaction ◽  
Oral Clefts ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Increased Risk ◽  
Polytomous Logistic Regression

Objective A meta-analysis was performed to examine the association among maternal cigarette smoking, infant genotype at the Taq1 site in the transforming growth factor α (TGFA) locus, and risk of nonsyndromic oral clefts, both cleft palate (CP) and cleft lip with or without cleft palate (CL/P). Design Five published case-control studies were included in the meta-analyis. Pooled Mantel-Haenszel odds ratios (OR) and 95% confidence intervals (CIs) were computed. Gene-environment interaction was also assessed by using the pooled data in a case-only analysis and polytomous logistic regression. Results Among nonsmoking mothers, there was no evidence of any increased risk for CP if the infant carried the TGFA Taq1 C2 allele. If the mother reported smoking, however, there was an overall increased risk for CP if the infant carried the C2 allele (ORsmokers = 1.95; 95% CI = 1.22 to 3.10). TGFA genotype did not increase risk to CL/P, regardless of maternal smoking status. Polytomous logistic regression revealed a significant overall smoking effect for CL/P (OR = 1.64, 95% CI = 1.33 to 2.02) and CP (OR = 1.42, 95% CI = 1.06 to 1.90). Conclusions While maternal smoking was a consistent risk factor for both CL/P and CP across all studies, the suggestive evidence for gene-environment interaction between the infant's genotype at the Taq1 marker in TGFA and maternal smoking was limited to CP. Furthermore, evidence for such gene-environment interaction was strongest in a case-control study drawn from a birth defect registry where infants with non-cleft defects served as controls.

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