Prevalence of Dental Anomalies in Nonsyndromic Individuals with Cleft Lip and Palate: A Systematic Review and Meta-analysis

2012 ◽  
Vol 49 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Patricia Nivoloni Tannure ◽  
Cristiana Aroeira G.R. Oliveira ◽  
Lucianne Copie Maia ◽  
Alexandre R. Vieira ◽  
José Mauro Granjeiro ◽  
...  
Keyword(s):  
Random Effects ◽  
Fixed Effects ◽  
Cleft Lip And Palate ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Permanent Teeth ◽  
Cochrane Library ◽  
Tooth Agenesis ◽  
Dental Anomalies ◽  
Oral Clefts

Objective To assess whether individuals born with nonsyndromic oral clefts display a higher frequency of dental anomalies. Design A search of MEDLINE, BIREME, OVID ALL EMB Reviews, and The Cochrane Library was conducted. The methodologic quality of the papers selected was assessed and scored. Papers reporting observational controlled studies of nonsyndromic forms of oral cleft matched for dental anomalies in primary and/or permanent teeth were included without language restrictions. Eligible studies were scored as “A”—low risk of bias, “B”—moderate risk of bias, or “C”—high risk of bias and poor quality. Fixed and random effects models were used to aggregate individual odds ratios (OR) and to derive pooled estimates and 95% confidence intervals. Results Six studies fulfilled our selection criteria and were included in the meta-analysis. Three distinct subgroup analyses were carried out in terms of dental anomalies. In the tooth agenesis meta-analysis, a random effects model was used because of heterogeneity and showed a significant association between tooth agenesis and oral clefts (OR = 12.31; 95% confidence interval [CI] = 3.75 to 40.36). In the remaining analyses, the fixed effects model revealed a positive association between supernumerary (OR = 4.99; 95% CI, 2.58 to 9.64) and crown morphologic abnormalities (OR = 5.69; 95% CI, 3.96 to 8.19) with oral clefts. Most included studies were of low to moderate quality. Conclusion Although general limitations in study design were observed, the evidence suggests that a higher number of dental anomalies in the permanent dentition are noted in individuals born with oral clefts.

scholarly journals Ear mould for congenital auricular deformities: a protocol for systematic review and meta-analysis

2020 ◽  
Author(s):  
Jincheng Huang ◽  
Kun Zou ◽  
Ping Yuan ◽  
Longhao Zhang ◽  
Min Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Evidence Base ◽  
Small Sample ◽  
Cochrane Library ◽  
Random Effects Model ◽  
High Quality ◽  
Effectiveness Rate

Abstract Background: Congenital auricle deformities (CADs) not only affect the appearance, but may also result in social inferiority or difficulties, influence the hearing and mental health of the children. Although some studies have pointed out CADs have a natural improvement trend, there is still a lack of high-quality research to demonstrate the degree of that. Therefore, related studies agree that early treatment are necessary. Ear mold correction is currently main non-surgical treatment for CADs, but the existing research often involves a small sample size, and the research conclusions are inconsistent. More importantly, there is still no systematic review on ear mold correction for CADs. This study aims to systematically evaluate the effectiveness and safety of ear mold correction for CADs, so as to provide an evidence base for further research.Methods: The study has been designed according to the Preferred Reporting program for Systems Evaluation and Meta-analysis Protocol (PRISMA-P). We will search electronic literature databases of PubMed, Embase, Cochrane Library, Web of science, CBM, CNKI, Wanfang and VIP from their initiative to 1 June 2020 for interventional studies on ear mould for children with CADs. The study selection, data extraction and quality assessment will be performed by two authors. Meta-analysis will be conducted on primary outcome effectiveness rate of physician assessment and secondary outcomes of effectiveness rate of parents’ assessment, effectiveness score, hearing assessment, and adverse reactions using relative ratio or mean difference and their 95% confidence intervals. The heterogeneity of the included studies will be tested using Chi square test and I2, and random-effects model will be used when significant heterogeneity was found, otherwise, fixed-effects model will be used. Sensitivity analysis will be performed using trials with high quality and using alternative [1]models (fixed-effects or random effects model). Publication bias will be tested using funnel plot and Egger’s test. Discussion: This study will be the first to systematically evaluate the effectiveness and safety of ear mold correction for CADs, to provide evidence base for clinical guideline making, clinical decision and future research. Systematic review registration : CRD42020190982.

scholarly journals Processed Electroencephalogram Monitoring and Postoperative Delirium

2018 ◽  
Vol 129 (3) ◽  
pp. 417-427 ◽  
Author(s):  
Kristen K. MacKenzie ◽  
Angelitta M. Britt-Spells ◽  
Laura P. Sands ◽  
Jacqueline M. Leung
Keyword(s):  
Cognitive Dysfunction ◽  
Fixed Effects ◽  
Postoperative Delirium ◽  
Meta Analysis ◽  
Postoperative Cognitive Dysfunction ◽  
Risk Of Bias ◽  
Adverse Outcomes ◽  
Cochrane Library ◽  
Google Search ◽  
The Relationship

Abstract What We Already Know about This Topic What This Article Tells Us That Is New Background Postoperative delirium complicates approximately 15 to 20% of major operations in patients at least 65 yr old and is associated with adverse outcomes and increased resource utilization. Furthermore, patients with postoperative delirium might also be at risk of developing long-term postoperative cognitive dysfunction. One potentially modifiable variable is use of intraoperative processed electroencephalogram to guide anesthesia. This systematic review and meta-analysis examines the relationship between processed electroencephalogram monitoring and postoperative delirium and cognitive dysfunction. Methods A systematic search for randomized controlled trials was conducted using Ovid MEDLINE, PubMed, EMBASE, Cochrane Library, and Google search using the keywords processed electroencephalogram, Bispectral Index, postoperative delirium, postoperative cognitive dysfunction. Screening and data extraction were conducted by two independent reviewers, and risk of bias was assessed. Postoperative delirium combined-effect estimates calculated with a fixed-effects model were expressed as odds ratios with 95% CIs. Results Thirteen of 369 search results met inclusion criteria. Postoperative cognitive dysfunction data were excluded in meta-analysis because of heterogeneity of outcome measurements; results were discussed descriptively. Five studies were included in the quantitative postoperative delirium analysis, with data pooled from 2,654 patients. The risk of bias was low in three studies and unclear for the other two. The use of processed electroencephalogram-guided anesthesia was associated with a 38% reduction in odds for developing postoperative delirium (odds ratio = 0.62; P < 0.001; 95% CI, 0.51 to 0.76). Conclusions Processed electroencephalogram-guided anesthesia was associated with a decrease in postoperative delirium. The mechanism explaining this association, however, is yet to be determined. The data are insufficient to assess the relationship between processed electroencephalogram monitoring and postoperative cognitive dysfunction.

scholarly journals Comparison of efficacy of robotic surgery, laparoscopy, and laparotomy in the treatment of ovarian cancer: a meta-analysis

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Can Shi ◽  
Yingchun Gao ◽  
Yijun Yang ◽  
Lei Zhang ◽  
Juanpeng Yu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Robotic Surgery ◽  
Publication Bias ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Estimated Blood Loss

Abstract Background We intended to compare the clinical effect of robotic surgery with laparoscopy and laparotomy in ovarian cancer treatment. Methods The included studies were retrieved from PubMed, Embase, and the Cochrane Library databases. The Methodological Index for Nonrandomized Studies (MINORS) was used to evaluate the study quality. Effect measures were presented with weighted mean difference (WMD)/odds ratio (OR) and 95% confidence interval (CI), and heterogeneity test was assessed using Q test and I2 statistics to determine the use of the random effects model or fixed effects model. Egger’s test was used to assess the publication bias. Results A total of eight studies was included in this meta-analysis with a MINORS score of 16–18. In the random effects model, estimated blood loss (EBL) of robotic surgery was significantly less compared with laparotomy (WMD = − 521.7027, 95% CI − 809.7816; − 233.6238). In the fixed effects model, length of hospital stay (LHS) (WMD = − 5.2225, 95% CI − 6.1485; − 4.2965) and postoperative complication (PC) (OR = 0.4710, 95% CI 0.2537; 0.8747) of robotic surgery were significantly less, and overall survival (OS) rate (OR = 6.4355, 95% CI 1.6722; 24.7678, P = 0.0070) of robotic surgery was significantly higher compared with laparotomy. There was no difference in the effect size of all variables between robotic surgery and laparoscopy. Meanwhile, a publication bias (t = 6.8290, P = 0.002405) was only identified for PC in robotic surgery and laparotomy groups; no publication bias was identified for the other variables. Conclusions Despite the above results, it failed to show oncological safety and recurrence by pathological stages or histologic types in this meta-analysis, and those confounding factors might affect the clinical outcome. Future meta-analyses with a larger number of eligible randomized controlled trial studies were needed to determine the most suitable treatment method for patients with different stages and types of ovarian cancer.

scholarly journals Prevalência de anomalias dentárias em radiografias panorâmicas

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Roque Soares Martins Neto ◽  
Ivna Freitas De Sousa Alves ◽  
Arthur Lima Machado ◽  
Luiz Alves Barbosa Neto ◽  
Andressa Aires Alencar ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Meta Analysis ◽  
Genetic Diseases ◽  
Third Molar ◽  
Sao Paulo ◽  
Permanent Teeth ◽  
Caries Experience ◽  
São Paulo ◽  
Dental Anomalies

Introdução: As anomalias de desenvolvimento dentário ocorrem devido a distúrbios que acontecem durante a formação e a diferenciação celular. Dentre as radiografias odontológicas, a panorâmica se destaca por ser um exame radiográfico mais abrangente, que auxilia no diagnóstico e no planejamento terapêutico dos processos patológicos dos dentes e dos ossos da face. Objetivo: O objetivo desse estudo é determinar a prevalência de anomalias dentárias em radiografias panorâmicas de pacientes em tratamento no Centro Universitário Católica de Quixadá-CE e no Centro de Especialidades Odontológicas de Quixeramobim-CE. Métodos: A análise radiográfica foi realizada por um único pesquisador e os achados radiográficos foram escritos em uma ficha devidamente desenvolvida para este estudo. Resultados: Foram analisadas 500 radiografias panorâmicas de pacientes que possuíam entre 5 e 50 anos de idade. Desses, 67% (n=333) pertenciam ao sexo feminino e 33% (n=167) ao masculino. Foi encontrado um total de 1150 anomalias, correspondentes a: dentes não irrompidos 41,7% (n=480), giroversão 24,4% (n=281), dilaceração radicular 20,3% (n=234), microdontia 6,7% (n=77), agenesia 3,9% (n=45), dentes supranumerários 2,4% (n=28), taurodontia 0,3% (n=4) e a macrodontia 0,1% (n=1). As radiografias também foram divididas pelo tipo de arcada ocorrendo 48% (n=307) na maxila e 52% (n=330), na mandíbula. As anomalias dentárias hiperplasiantes foram encontradas em 2,9% (n=33) da amostra, as hipoplasiantes em 10,6% (n=122) e as heterotópicas em 86,5% (n=995). Desta forma conclui-se que na população estudada a maior prevalência correspondeu ao sexo feminino, à anomalia de desenvolvimento heterotópica e ao dente não irrompido.Descritores: Anormalidades Dentárias; Radiografia; Radiografia Panorâmica.ReferênciasCarneiro GV. Estudo radiográfico da prevalência de anomalias dentárias por meio de radiografias panorâmicas em diferentes faixas etárias [tese]. Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste; 2014.Seabra M, Macho V, Pinto A, Soares D, Andrade C. A importância das anomalias dentárias de desenvolvimento. Acta Pediatr Port. 2008;39(5):195-200.Álvares LC, Tavano O. Curso de radiologia em odontlogia. São Paulo: Santos; 2009.Paula, AFB, Ferrer KJN. Prevalência de agenesia em uma clínica ortodôntica de Goiânia. RGO. 2007;55(2):149-53.Gartner CF, Goldenberg FC. A importância da radiografia panorâmica no diagnóstico e no plano de tratamento ortodôntico na fase da dentadura mista. Rev Odonto. 2009;17(33):102-9.Barbieri AA. A importância da radiografia panorâmica como instrumento auxiliar às práticas clínica e odontolegal [dissertação]. São José dos Campos: Universidade Estadual Paulista; 2011.Santos MR, Olibeira KL, Fonte JBM, Hora IAA, Takeshita WM, Melo MFB. Prevalência De Alterações Dentárias Em Pacientes Com Síndrome De Down Avaliados Por Meio De Radiografia Panorâmica. Rev Odontol Univ Cid São Paulo. 2014;26(2):112-18.Pereira AC, Nishiyama CK, Pinto LC. Anomalias dentárias em indivíduos com fissura transforame incisivo unilateral e o tratamento endodôntico. RFO UPF. 2013;18(3):328-34.Scarpim MFPA, Nunes VS, Cerci BB, Azevedo LR, Tolazzi AL, Grégio AMT et al. Prevalência de anomalias dentárias em pacientes avaliados para tratamento ortodôntico: estudo retrospectivo. Clin Pesq Odontol. 2006;2(3):203-12.Torres PF, Simplício AHM, Luz ARCA, Lima MDM, Moura LFAD, Moura MS. Anomalias dentárias de número em pacientes ortodônticos. Rev Odontol UNESP. 2015;44(5):280-84Girondi JR, Fenyo-Pereira M, Campos PSF, Panella J. Estudo da prevalência das anomalias dentárias de desenvolvimento em dada população com o uso de radiografi as panorâmicas. Rev Odont Univ Cid São Paulo. 2006;18(1):15-21.Canoglu E, Canoglu H, Aktas A, Cehreli ZC. Isolated bilateral macrodontia of mandibular second premolars: a case report. Eur J Dent. 2012;6(3):330-34.Menini AAS, Silva MC, Iwaki LCV, Takeshita WM. Estudo radiográfico da prevalência de anomalias dentárias por meio de radiografias panorâmicas em diferentes faixas etárias. Rev Odontol Univ Cid São Paulo. 2012;24(3):170-77.Barbosa DFM, Cruz CM, Crepaldi MV, Oliveira BLS. Agenesias múltiplas, planejamento e hereditariedade. Rev Faipe. 2016;6(2):14-27.Inoue T, Saito M, Nishimura F, Miyazaki T. Three-dimensional representation of microdontia of the maxillary third molar. Clin Case Rep. 2017;5(4):547-48.Costa MA, Oliveira AEF, Costa JF, Silva RA, Lopes FF, Silva APB. Incidência das posições anatômicas e agenesia dos terceiros molares em estudantes de São Luís, Maranhão. Pesqui bras odontopediatria clin integr. 2010;10(3):399-403.King NM, Wong WL, Wong HM. Caries experience of Chinese children with cleft lip and palate. Cleft Palate Craniofac J. 2013;50(4):448-55.Yamada N. Radiographic abnormalities in genetic diseases. Dent Outl. 1983;62(1):71-8.Guttal KS, Naikmasur VG, Bhargava P, Bathi RJ. Frequency of developmental dental anomalies in the Indian population. Eur J Dent. 2010;4(3):263-69.Garib DG, Alencar BM, Ferreira FV, Ozawa TO. Anomalias dentárias associadas: o ortodontista decodificando a genética que rege os distúrbios de desenvolvimento dentário. Dental Press J Orthod. 2010;15(2):138-57.Colombo LT, Paulon SS, Coclete GA, Coclete GEG, Gaetti Jardim Junior E, Castro AL. Giroversão dental presente ou ausente em radiografias panorâmicas. Arch Health Invest. 2013;2(Esp 2):224.Teixeira VP, Martins MAT, Lascala CA, Marques MM, Rossi JM, Missawa GTM et al. Estudo de anormalidades dentárias de desenvolvimento em pacientes em tratamento ortodôntico Study of development dental abnormalities in orthodontic patients. Rev Inst Ciênc Saúde. 2008;26(4):454-57.Polder BJ, Van’t Hof MA, Van der Linden FP, Kuijpers-Jagtman AM. A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol. 2009;32(3):217-26.Mafra RP, Vasconcelos RG, Vasconcelos MG, Queiroz LMG, Barboza CAG. Desenvolvimento dental: aspectos morfogenéticos e relações com as anomalias dentárias do desenvolvimento. Rev bras odontol. 2012;69(2):232-37.Ezoddini AF, Sheikhha MH, Ahmadi H. Prevalence of dental anomalies: a radiographic study. Community Dent Health. 2007;424(3):140-44.

Time of maxillary molar distalization with non-compliance intraoral distalizing appliances: a meta-analysis

2019 ◽  
Vol 41 (6) ◽  
pp. 652-660 ◽  
Author(s):  
Silvio Augusto Bellini-Pereira ◽  
Daniela Cubas Pupulim ◽  
Aron Aliaga-Del Castillo ◽  
José Fernando Castanha Henriques ◽  
Guilherme Janson
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Prospective Studies ◽  
Meta Analysis ◽  
Class Ii ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Molar Distalization ◽  
Maxillary Molar ◽  
The Mean

Summary Background/Objective To assess the mean maxillary molar distalization time with non-compliance intraoral distalizing appliances. Search methods and selection criteria Database search included PubMed, Web of Science, Scopus, The Cochrane Library, Lilacs, and a partial grey literature through Google Scholar and OpenGrey. The search was performed until May 2017 and updated on February 2019, without limitations regarding publication year or language. Controlled clinical trials (randomized and non-randomized prospective studies) reporting duration of maxillary molar distalization of Class II patients treated with intraoral distalizers were included. Data collection and analysis For the trials’ quality assessment, the Cochrane Risk of Bias tool and the Cochrane Collaboration’s ROBINS-I tool were used for the randomized controlled trials and non-randomized prospective studies, respectively. Database research, risk of bias (RoB) assessment, and extraction of data were performed by two independent investigators, with inclusion of a third reviewer, if disagreements emerged. Data was combined through a random-effects meta-analysis. Subgroup analyses regarding side of force application, type of anchorage, amount of molar distalization, and sensitivity analysis comparing study designs were also performed. Quality of evidence was assessed using the GRADE and SORT approaches. Results Nine studies were included in the qualitative analysis; however, a meta-analysis was performed with only four studies, due to the presence of high RoB in the other studies. The random-effects meta-analysis assumes that the mean distalization time with distalizers is 8.34 months (95% confidence interval: 6.10, 10.58). Another meta-analysis was performed to evaluate the relationship between distalization time and the type of anchorage (conventional or skeletal), resulting in no significant difference. Both meta-analyses presented low-quality evidence. Limitations The major limitation of this meta-analysis is the fact that distalization time can be affected by a great range of factors. Conclusions and implications Correction of a half-to-full cusp Class II molar relationship with intraoral distalizers can be achieved in 8.34 months, and this distalization time may not be affected by the kind of anchorage used. Registration The protocol for this systematic review was based on the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 and was registered at PROSPERO database (http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017068737). This systematic review is reported according to the PRISMA statement.

scholarly journals Effectiveness of Nutritional Education for Obese Older Adults With Frailty: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 401-401
Author(s):  
Yue-Heng Yin ◽  
Liu Yat Justina
Keyword(s):  
Systematic Review ◽  
Physical Function ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Well Being ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Nutritional Education ◽  
Hand Search ◽  
Education Interventions

Abstract Obesity has been shown to intensify the decline of physical function and lead to frailty. Nutrition is an important method in managing obesity and frailty, while seldom reviews have ever explored the effects of nutritional education interventions. We conducted a systematic review (PROSPERO: CRD42019142403) to explore the effectiveness of nutritional education interventions in managing body composition and physio-psychosocial parameters related to frailty. Randomized controlled trials and quasi-experimental studies were searched in CINAHL, Cochrane Library, EMBASE, MEDLINE, PsycINFO, PubMed and Scopus from 2001 to 2019. Hand search for the reference lists of included papers was conducted as well. We assessed the quality of included studies by Cochrane risk of bias tool. Meta-analyses and narrative synthesis were used to analyse the data. Two studies with low risk of bias were screened from 180 articles, which involved 177 older people with an average age of 69.69±4.08 years old. The results showed that nutritional education was significantly effective in reducing body weight and fat mass than exercises, and it was beneficial to enhancing physical function and psychosocial well-being. But the effects of nutritional education in increasing muscle strength were not better than exercises. The combined effects of nutritional education and exercises were superior than either exercises or nutritional education interventions solely in preventing the loss of lean mass and bone marrow density, and in improving physical function. Due to limited numbers of relevant studies, the strong evidence of effectiveness of nutritional education interventions on reversing frailty is still lacking.

scholarly journals Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040997
Author(s):  
Varo Kirthi ◽  
Paul Nderitu ◽  
Uazman Alam ◽  
Jennifer Evans ◽  
Sarah Nevitt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diabetic Retinopathy ◽  
Data Extraction ◽  
Meta Analysis ◽  
International Diabetes Federation ◽  
Current Data ◽  
Risk Of Bias ◽  
Fundus Photography ◽  
Primary Data ◽  
Cochrane Library

IntroductionThere is growing evidence of a higher than expected prevalence of retinopathy in prediabetes. This paper presents the protocol of a systematic review and meta-analysis of retinopathy in prediabetes. The aim of the review is to estimate the prevalence of retinopathy in prediabetes and to summarise the current data.Methods and analysisThis protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) guidelines. A comprehensive electronic bibliographic search will be conducted in MEDLINE, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Google Scholar and the Cochrane Library. Eligible studies will report prevalence data for retinopathy on fundus photography in adults with prediabetes. No time restrictions will be placed on the date of publication. Screening for eligible studies and data extraction will be conducted by two reviewers independently, using predefined inclusion criteria and prepiloted data extraction forms. Disagreements between the reviewers will be resolved by discussion, and if required, a third (senior) reviewer will arbitrate.The primary outcome is the prevalence of any standard features of diabetic retinopathy (DR) on fundus photography, as per International Clinical Diabetic Retinopathy Severity Scale (ICDRSS) classification. Secondary outcomes are the prevalence of (1) any retinal microvascular abnormalities on fundus photography that are not standard features of DR as per ICDRSS classification and (2) any macular microvascular abnormalities on fundus photography, including but not limited to the presence of macular exudates, microaneurysms and haemorrhages. Risk of bias for included studies will be assessed using a validated risk of bias tool for prevalence studies. Pooled estimates for the prespecified outcomes of interest will be calculated using random effects meta-analytic techniques. Heterogeneity will be assessed using the I2 statistic.Ethics and disseminationEthical approval is not required as this is a protocol for a systematic review and no primary data are to be collected. Findings will be disseminated through peer-reviewed publications and presentations at national and international meetings including Diabetes UK, European Association for the Study of Diabetes, American Diabetes Association and International Diabetes Federation conferences.PROSPERO registration numberCRD42020184820.

scholarly journals Effectiveness of Antalgic Therapies in Patients with Vertebral Bone Metastasis: A Protocol for a Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (8) ◽  
pp. 3991
Author(s):  
Antonio Jose Martin-Perez ◽  
María Fernández-González ◽  
Paula Postigo-Martin ◽  
Marc Sampedro Pilegaard ◽  
Carolina Fernández-Lao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Metastasis ◽  
Data Extraction ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Pharmacological Intervention ◽  
Vertebral Metastasis ◽  
Randomized Controlled Clinical Trials

There is no systematic review that has identified existing studies evaluating the pharmacological and non-pharmacological intervention for pain management in patients with bone metastasis. To fill this gap in the literature, this systematic review with meta-analysis aims to evaluate the effectiveness of different antalgic therapies (pharmacological and non-pharmacological) in the improvement of pain of these patients. To this end, this protocol has been written according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) and registered in PROSPERO (CRD42020135762). A systematic search will be carried out in four international databases: Medline (Via PubMed), Web of Science, Cochrane Library and SCOPUS, to select the randomized controlled clinical trials. The Risk of Bias Tool developed by Cochrane will be used to assess the risk of bias and the quality of the identified studies. A narrative synthesis will be used to describe and compare the studies, and after the data extraction, random effects model and a subgroup analyses will be performed according to the type of intervention, if possible. This protocol aims to generate a systematic review that compiles and synthesizes the best and most recent evidence on the treatment of pain derived from vertebral metastasis.

scholarly journals Adjuvant Transarterial Chemoembolization Following Curative-Intent Hepatectomy Versus Hepatectomy Alone for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2984
Author(s):  
Stepan M. Esagian ◽  
Christos D. Kakos ◽  
Emmanouil Giorgakis ◽  
Lyle Burdine ◽  
J. Camilo Barreto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Transarterial Chemoembolization ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Curative Intent ◽  
Randomized Controlled

The role of adjuvant transarterial chemoembolization (TACE) for patients with resectable hepatocellular carcinoma (HCC) undergoing hepatectomy is currently unclear. We performed a systematic review of the literature using the MEDLINE, Embase, and Cochrane Library databases. Random-effects meta-analysis was carried out to compare the overall survival (OS) and recurrence-free survival (RFS) of patients with resectable HCC undergoing hepatectomy followed by adjuvant TACE vs. hepatectomy alone in randomized controlled trials (RCTs). The risk of bias was assessed using the Risk of Bias 2.0 tool. Meta-regression analyses were performed to explore the effect of hepatitis B viral status, microvascular invasion, type of resection (anatomic vs. parenchymal-sparing), and tumor size on the outcomes. Ten eligible RCTs, reporting on 1216 patients in total, were identified. The combination of hepatectomy and adjuvant TACE was associated with superior OS (hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.52 to 0.85; p < 0.001) and RFS (HR: 0.70, 95% CI: 0.56 to 0.88; p < 0.001) compared to hepatectomy alone. There were significant concerns regarding the risk of bias in most of the included studies. Overall, adjuvant TACE may be associated with an oncologic benefit in select HCC patients. However, the applicability of these findings may be limited to Eastern Asian populations, due to the geographically restricted sample. High-quality multinational RCTs, as well as predictive tools to optimize patient selection, are necessary before adjuvant TACE can be routinely implemented into standard practice. PROSPERO Registration ID: CRD42021245758.

scholarly journals Association of bisphenol A with puberty timing: a meta-analysis

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hui Meng ◽  
Yunping Zhou ◽  
Yunxia Jiang
Keyword(s):  
Bisphenol A ◽  
Confidence Intervals ◽  
Random Effects ◽  
Strong Correlation ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Random Effects Models ◽  
Study Heterogeneity ◽  
The Relationship ◽  
Prevalence Ratios

AbstractObjectivesThe results of existing studies on bisphenol A (BPA) and puberty timing did not reach a consensus. Thereby we performed this meta-analytic study to explore the association between BPA exposure in urine and puberty timing.MethodsMeta-analysis of the pooled odds ratios (OR), prevalence ratios (PR) or hazards ratios (HR) with 95% confidence intervals (CI) were calculated and estimated using fixed-effects or random-effects models based on between-study heterogeneity.ResultsA total of 10 studies involving 5621 subjects were finally included. The meta-analysis showed that BPA exposure was weakly associated with thelarche (PR: 0.96, 95% CI: 0.93–0.99), while no association was found between BPA exposure and menarche (HR: 0.99, 95% CI: 0.89–1.12; OR: 1.02, 95% CI: 0.73–1.43), and pubarche (OR: 1.00, 95% CI: 0.79–1.26; PR: 1.00, 95% CI: 0.95–1.05).ConclusionsThere was no strong correlation between BPA exposure and puberty timing. Further studies with large sample sizes are needed to verify the relationship between BPA and puberty timing.

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