A comparative study to evaluate the effect of limited access dressing (LAD) on burn wound healing

BACKGROUND: Topical sucralfate has been used for burn and non-burn skin and mucosal lesion with remarkable results. The healing rate of mucosa is faster than skin lesion. AIM: A current systematic review was conducted to objectively evaluate wound healing benefits of topical sucralfate for burn wound and to show on which degree of burn wound it works compare with another topical agents of burn wound therapy. METHODS: Databases were searched for relevant studies: Google Scholar, PUBMED, and ProQuest. Data sources were searched using MeSH terms: “topical sucralfate” and “burn wound” for all publications up to December 2018. All English papers were included. Only studies performed in humans were included in this study. A total of 2437 publications were found, of which 3 studies met the inclusion criteria and were relevant to be used in this systematic review. The primary outcome was burn wound healing. DATA EXTRACTION: Data from retrieved studies were reviewed and tabulated according to year of publication, study design, human or animal studies, characteristics of the population, and outcomes. DATA SYNTHESIS: A total of 2 randomized controlled trials (RCTs) and 1 observational comparative study were found. All trials are on second degree burn wound patients. Jadad score was used to assess the methodological quality of the RCTs. One RCT and one comparative study demonstrated favorable outcomes with the use of topical sucralfate. There is one publication with no significant differences. CONCLUSIONS: This systematic review shows a noticeably beneficial effect of topical sucralfate for burn wound. It is better than other topical agent in wound healing rate, decreased infection rate and enhancement of epithelialization also granulation with no local or systemic adverse reactions. However, multicenter RCT with larger sample size are needed to make recommendation for burn wound treatment.

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Burn Wound Healing Potential of Honey, Sandal Wood, Calendula and Cooling with Tap Water-A Comparative Study on Wistar Rats

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2018/36971.12125 ◽

2018 ◽

Author(s):

Jayshree Shriram Dawane ◽

Anand Biradar ◽

Ketan Vaidya ◽

Ashutosh Sharma ◽

Madhura Bhosale ◽

...

Keyword(s):

Wound Healing ◽

Comparative Study ◽

Wistar Rats ◽

Tap Water ◽

Burn Wound ◽

Burn Wound Healing

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The Effect of Age on Pain Sensitivity during Burn Wound Healing in Dairy Calves

10.1055/s-0038-1646777 ◽

2018 ◽

Author(s):

S. Adcock ◽

C. Tucker

Keyword(s):

Wound Healing ◽

Pain Sensitivity ◽

Dairy Calves ◽

Burn Wound ◽

Burn Wound Healing ◽

Effect Of Age

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The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.10.1.8 ◽

2019 ◽

Vol 10 (01) ◽

Author(s):

Sritharadol Rutthapol ◽

Chunhachaichana Charisopon ◽

Kumlungmak Sukanjana ◽

Buatong Wilaiporn ◽

Dechraksa Janwit ◽

...

Keyword(s):

Wound Healing ◽

Matrix Metalloproteinase ◽

Rat Model ◽

Transforming Growth Factor ◽

Immunohistochemical Study ◽

Enzyme Linked Immunosorbent Assay ◽

Burn Wound ◽

Safety And Efficacy ◽

Burn Wound Healing ◽

Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

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Evaluation of Liver and Kidney Toxicity in Rats Receiving Proteoglycans from Fish Cartilage for the Acceleration of Burn Wound Healing

The Bangkok Medical Journal ◽

10.31524/bkkmedj.2016.02.003 ◽

2016 ◽

Vol 11 (01) ◽

pp. 11-16

Author(s):

Sitthiphon Bunman ◽

Narongpon Dumavibhat ◽

Noppadol Larbcharoensub

Keyword(s):

Wound Healing ◽

Burn Wound ◽

Kidney Toxicity ◽

Burn Wound Healing ◽

Liver And Kidney

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Validity of thermography for measuring burn wound healing potential

Wound Repair and Regeneration ◽

10.1111/wrr.12786 ◽

2019 ◽

Vol 28 (3) ◽

pp. 347-354 ◽

Cited By ~ 2

Author(s):

Michelle E. Carrière ◽

Louise E. M. Haas ◽

Anouk Pijpe ◽

Annebeth Meij‐de Vries ◽

Kim L. M. Gardien ◽

...

Keyword(s):

Wound Healing ◽

Burn Wound ◽

Burn Wound Healing

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556 The Use of a Concentrated Surfactant Based Gel to Promote Burn Wound Healing

Journal of Burn Care & Research ◽

10.1093/jbcr/irab032.206 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

pp. S126-S127

Author(s):

Rebecca Coffey ◽

Rachel Penny

Keyword(s):

Wound Healing ◽

New Product ◽

Ease Of Use ◽

Burn Injuries ◽

Full Thickness ◽

Burn Wound ◽

Burn Wounds ◽

Burn Care ◽

Product Trial ◽

Burn Wound Healing

Abstract Introduction Strategies to remove necrotic tissue from burn wounds include excisional and non-excisional debridement. Alternative treatments could promote burn wound healing while minimizing patient discomfort and the need for surgery. We evaluated the usage of a concentrated surfactant gel (CSG) to promote burn wound healing in those with indeterminate depth and full thickness burn injuries. Methods An IRB approved retrospective study was conducted during a 10-patient new product trial period with enrollment between September and October 2019. Patients included in this study had indeterminate or full thickness burn wounds and were treated with a concentrated surfactant-based gel. Patients with non-burn diagnoses were excluded. Data collected included demographic information, injury descriptors, and additional burn wound characteristics. Results A total of 10 patients were included in this study as part of a new product trial. The subjects were 80% male with an average TBSA of 7.5%. 40% had indeterminate and 60% had full thickness burn wounds. Prior to initiation of the CSG, the burn wounds had been open for an average of 41 days. There were no infections or complications with usage of the CSG. 90% of patients reported less pain than the standard of care topical agents for burns. Average duration of treatment with the CSG until healing was 28 days. After usage of the CSG, no patients required surgery. Conclusions Our findings support the usage of a concentrated surfactant-based gel in patients with burn wounds. Patients reported decreased pain during dressing changes and ease of use compared to the standard topical agent in burn care. It also prevented surgical debridement in those with indeterminate and full thickness burn injuries.

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