scholarly journals Burn Wound Healing Potential of Honey, Sandal Wood, Calendula and Cooling with Tap Water-A Comparative Study on Wistar Rats

2018 ◽  
Author(s):  
Jayshree Shriram Dawane ◽  
Anand Biradar ◽  
Ketan Vaidya ◽  
Ashutosh Sharma ◽  
Madhura Bhosale ◽  
...  
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Wistar Rats ◽  
Tap Water ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals Burn Wound Healing Activity of Prunella Grandiflora L. Exctract

Biomeditsina ◽  
2021 ◽  
Vol 17 (4) ◽  
pp. 50-56
Author(s):  
E. V. Bolotnik ◽  
L. I. Alekseeva ◽  
L. P. Larionov
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Dosage Forms ◽  
Control Groups ◽  
Burn Wound ◽  
Dry Extract ◽  
Burn Wound Healing ◽  
Male Wistar Rats ◽  
And Control ◽  
Wound Healing Activity

The qualitative composition of phenolic acids and burn wound healing activity of Prunella grandiflora L. extract were studied. The content of rosmarinic (621±5 mg/g), coffeic (11.2±0.2 mg/g), syringic (46.5±1.4 mg/g), n-coumaric (25.8±0.5 mg/g), and ferulic (42.7±2.9 mg/g) acids in dry extracts of P. grandiflora was determined by HPLC. Three new burn-healing agents of different composition containing 5% of the dry extract of Prunella grandiflora L. (big-flowered self-heal) were developed. The developed agents were tested on male Wistar rats with second- and third-degree thermal burns. An assessment of skin restoration was carried out in experimental and control groups of animals. It was revealed that animals treated with the developed soft dosage forms restored the epithelium and coat 6–8 days faster that those treated with compositions containing no extract under study. It was found that the developed soft dosage forms based on P. grandiflora extract exhibit anti-inflammatory and wound-healing action.

scholarly journals A comparative study to evaluate the effect of limited access dressing (LAD) on burn wound healing

2015 ◽  
Vol 13 (5) ◽  
pp. 791-798
Author(s):  
Thittamaranahalli M Honnegowda ◽  
Pramod Kumar ◽  
Echalasara G Padmanabha Udupa ◽  
Anurag Sharan ◽  
Rekha Singh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Burn Wound ◽  
Limited Access ◽  
Burn Wound Healing

scholarly journals A Systematic Review: Topical Sucralfate for Burn Wound

2021 ◽  
Vol 9 (F) ◽  
pp. 516-522
Author(s):  
Loelita Lumintang ◽  
Made S. Adnyana ◽  
I. Nyoman Putu Riasa ◽  
Anak Agung Gde Ngurah Asmarajaya ◽  
Agus Roy Hamid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Comparative Study ◽  
Animal Studies ◽  
Healing Rate ◽  
Data Extraction ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Mesh Terms ◽  
Multicenter Rct

BACKGROUND: Topical sucralfate has been used for burn and non-burn skin and mucosal lesion with remarkable results. The healing rate of mucosa is faster than skin lesion. AIM: A current systematic review was conducted to objectively evaluate wound healing benefits of topical sucralfate for burn wound and to show on which degree of burn wound it works compare with another topical agents of burn wound therapy. METHODS: Databases were searched for relevant studies: Google Scholar, PUBMED, and ProQuest. Data sources were searched using MeSH terms: “topical sucralfate” and “burn wound” for all publications up to December 2018. All English papers were included. Only studies performed in humans were included in this study. A total of 2437 publications were found, of which 3 studies met the inclusion criteria and were relevant to be used in this systematic review. The primary outcome was burn wound healing. DATA EXTRACTION: Data from retrieved studies were reviewed and tabulated according to year of publication, study design, human or animal studies, characteristics of the population, and outcomes. DATA SYNTHESIS: A total of 2 randomized controlled trials (RCTs) and 1 observational comparative study were found. All trials are on second degree burn wound patients. Jadad score was used to assess the methodological quality of the RCTs. One RCT and one comparative study demonstrated favorable outcomes with the use of topical sucralfate. There is one publication with no significant differences. CONCLUSIONS: This systematic review shows a noticeably beneficial effect of topical sucralfate for burn wound. It is better than other topical agent in wound healing rate, decreased infection rate and enhancement of epithelialization also granulation with no local or systemic adverse reactions. However, multicenter RCT with larger sample size are needed to make recommendation for burn wound treatment.

scholarly journals FORMULATION OF GEL FROM GYNURA SEGETUM EXTRACT AND ITS ACTIVITY ON BURN WOUND HEALING

2021 ◽  
pp. 269-271
Author(s):  
ARIF BUDIMAN ◽  
MUHARAM ◽  
ANIDA CRISTI MAULIDA ◽  
DIAH LIA AULIFA
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Healing Process ◽  
Physical Stability ◽  
Wound Healing Process ◽  
Burn Wound ◽  
Hot Plate ◽  
Topical Preparation ◽  
Burn Wound Healing ◽  
Male Wistar Rats

Objective: The aims of this study were to formulate gel from Gynura segetum (GS) extract and evaluate its burn-healing activity. Methods: GS extract was formulated using carbomer and carboxymethylcellulose (CMC) as a stabilizer with various concentrations. Furthermore, the gel of GS extract was evaluated, including organoleptic, pH and viscosity. A burn-healing evaluation was conducted by making a wound with a hot plate on male Wistar rats, and 600 mg of the gel was applied. Subsequently, the presence of erythema and width contraction of the burns were observed for 15 d. Results: The result showed that the formulation containing 1 % of carbomer and 1.2 % of GS extract has the best physical stability. The gel also increased the rate of the healing process with decreased burn wound contraction (5.67 mm after 15 d) and the erythema than the control (8.50 mm after 15 d). The significance value was less than 0.05, indicating that the rate of the healing process was significantly different between the GS extract gel and the control. Conclusion: This finding demonstrated that the gel of GS extract can significantly improve the burns wound healing process and may also be safely used for topical preparation.

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

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