A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats

These experiments were conducted in order to compare the effects of extractum cepae, heparin, allantoin gel (CTBX) and silver sulfadiazine (SSD) cream on burn wound healing in rats. Thirty six adult, female Wistar albino rats were divided into three equal groups. A burn was made on the back of all rats. The burned areas in the first, second and third groups were covered with cold cream (control), SSD skin cream and CTBX twice a day, respectively. Seven and 14 days later, the rats were sacrificed and burned skin tissue samples were collected from the rats for histopathological examinations. Histopatological evaluations on the 7<sup>th</sup> and 14<sup>th</sup> days showed burn healing to be better in the CTBX and SSD groups with respect to the control group. The best burn wound healing was observed in the CTBX group (P < 0.001). Wound healing was significantly different between the groups at days 7 and 14 (P < 0.001). In conclusion, application of CTBX has significant positive effects on the healing of burn wounds in a rat model.  

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Comparing the effects of silver sulfadiazine and cerium nitrate silver sulfadiazine on burn-wound healing and survival rate of rat animal model

Journal of Surgery and Medicine ◽

10.28982/josam.515121 ◽

2019 ◽

Cited By ~ 1

Author(s):

Latifi Nur-Ahmad ◽

Fatemi-DokhtCharuk Mohammad-Javad ◽

Salahi-Kajur Ali-Asghar ◽

Hedayatpour Azim

Keyword(s):

Wound Healing ◽

Animal Model ◽

Survival Rate ◽

Silver Sulfadiazine ◽

Cerium Nitrate ◽

Burn Wound ◽

Burn Wound Healing ◽

Rat Animal Model

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Comparison Profile of Nutrition Status in Stage V Chronic Kidney Disease Patients Hemodialyzing Using New and Reuse Dialyzer

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v5i2.9613 ◽

2019 ◽

Vol 5 (2) ◽

pp. 17

Author(s):

Yuli Hermansyah ◽

Ika Aulia Kurniasari ◽

Heni Fatmawati

Keyword(s):

Oxidative Stress ◽

Wound Healing ◽

Antioxidant Properties ◽

Negative Control ◽

Silver Sulfadiazine ◽

Control Group ◽

Burn Wound ◽

Burn Wound Healing ◽

Degree Burn ◽

Significant Difference

Burn wound healing process consists of three phases of inflammation, proliferation and remodelling. The number of fibroblasts has increased during the proliferation phase. Oxidative stress in burn may disrupt proliferation through TGF-β inhibition, result in decreased number of fibroblasts and poor burn wound healing. Genistein in edamame seeds has anti-inflammatory, antibacterial and antioxidant properties. Edamame contains vitamins A, C, and E which is also have antioxidant properties. Edamame has been suggested to protect burn wound healing from oxidative stress. This study aimed to understand the effectiveness of edamame seed (Glycine max L. Merril) ethanolic extract (ED) to fibroblast count in second degree burn wound healing. This is true experimental research with post test only control group design. The sample of this research was 24 rat models of second degree burn which was made by attaching hot metal (60 ° C) for 5 seconds on the shaved back of the rats. The sample was divided into 6 groups with topical treatment, among others: positive control group (silver sulfadiazine), negative control group (Na CMC 0.5%), group with ED 20%, ED 40%, ED 60%, and ED 80%. Treatment was given for 15 days and skin sample was taken on the 16th day. Observation of the number of fibroblasts was done by taking pictures of histhologic preparations in Hematoxylin and Eosin staining under 400x magnification of light microscope. In one way ANOVA test, significance value of 0.011 (p≤0,05) indicated that there was at least a significant difference between 2 groups. LSD’s post hoc analysis showed that there was a significant difference in the group ED 20, 40, and 60% compared with negative control. Keyword: burn wound healing, vegetable soybean, genistein, fibroblast count, silver sulfadiazine

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Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

BioMed Research International ◽

10.1155/2014/748101 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Pawel Olczyk ◽

Katarzyna Komosinska-Vassev ◽

Grzegorz Wisowski ◽

Lukasz Mencner ◽

Jerzy Stojko ◽

...

Keyword(s):

Wound Healing ◽

Healing Process ◽

Silver Sulfadiazine ◽

Wound Healing Process ◽

Burn Wound ◽

Burn Treatment ◽

Burn Wound Healing ◽

Fibronectin Expression ◽

The Matrix ◽

Healing Wounds

The aim of the study was to assess the propolis effect on fibronectin metabolism in the course of burn wounds healing process. A model of burn wound healing of pig skin was applied. The amount of the released glycoprotein was assessed by a surface plasmon resonance. The profile of extracted fibronectin components was also assessed by an electrophoresis in polyacrylamide gel, with a subsequent immunodetection by Western Blotting. Propolis burn treatment decreased the release of fibronectin components from healing wounds in relation to damages treated with silver sulfadiazine. The main reason of decreased extraction of fibronectin components from wounds treated with propolis was a substantial decrease of degradation product release of the mentioned glycoprotein, which was observed particularly from the 3rd to 5th day of the repair. Wounds treatment with propolis demonstrated, especially in relation to damages treated with silver sulfadiazine, the decreased release of synthesized fibronectin molecules. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process. The influence of propolis is reflected in prevention of fibronectin biosynthesis as well as its degradation in the wound area. The above-mentioned metabolic changes may decrease the risk of complications in the repair wounds process.

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Topical treatment of standardised burns with herbal remedies in model rats

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2005.3233 ◽

2005 ◽

Vol 5 (4) ◽

pp. 50-57 ◽

Cited By ~ 1

Author(s):

Fahir Bečić ◽

Nedžad Mulabegović ◽

Zakira Mornjaković ◽

Elvedina Kapić ◽

Senad Prašović ◽

...

Keyword(s):

Wound Healing ◽

Healing Process ◽

Silver Sulfadiazine ◽

Herbal Remedies ◽

Control Group ◽

Therapeutic Effects ◽

Skin Area ◽

Burn Wound ◽

Burn Wounds ◽

Burn Wound Healing

Experimental studies of burns require the use of different animal models. The aim of this work was to establish experimental model of thermal injuries and to evaluate the effects of topical agents on healing of the burn wounds. Forty female Wistar rats were randomly classified in 4 groups and isolated for 2 weeks before the onset of experiment. Animals were primarily anaesthetized with pentobarbital-sodium and then shaved (skin area of their back with diameters 5 cm x 5 cm). A round metal stamp with contact area of 5 cm2 and total weight of 100 g was heated up to 80°C and then applied without additional pressure on the depilated skin of the back for 14 seconds. This procedure produced a standardized burn wound. Induced burn wounds were immediately drowned in the 4°C-water for 3 s in order to maintain microcirculation. After the inducement of thermal injures, all rats were treated with 1% silver sulfadiazine cream, herbal topical preparations or were not treated at all. Burn wounds were treated twice a day until the healing completion. The result of treatment application was a significant reduction of burn wound diameters. Herbal topical preparations expressed positive therapeutic effects on the parameters of burn wounds. The efficiency of silver sulfadiazine cream in burn wound healing was significantly more expressed in comparison to healing process in control group of animals (p<0,001). We conclude that herbal topical preparations efficiently caused the completion of burn wound healing process without scar formation.

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Evaluation of burn wound healing property of Hemidesmus indicus with and without supportive treatment of ointment silver sulfadiazine in rabbits

National Journal of Physiology Pharmacy and Pharmacology ◽

10.5455/njppp.2019.9.0519623052019 ◽

2019 ◽

pp. 1

Author(s):

Vaibhav Gupta

Keyword(s):

Wound Healing ◽

Silver Sulfadiazine ◽

Supportive Treatment ◽

Burn Wound ◽

Hemidesmus Indicus ◽

Burn Wound Healing ◽

Healing Property ◽

Wound Healing Property

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A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine

Burns ◽

10.1016/s0305-4179(97)00113-7 ◽

1998 ◽

Vol 24 (2) ◽

pp. 157-161 ◽

Cited By ~ 173

Author(s):

M. Subrahmanyam

Keyword(s):

Wound Healing ◽

Histological Study ◽

Silver Sulfadiazine ◽

Burn Wound ◽

Burn Wound Healing

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Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats

Veterinární Medicína ◽

10.17221/2948-vetmed ◽

2010 ◽

Vol 55 (No. 12) ◽

pp. 619-624 ◽

Cited By ~ 36

Author(s):

I. Yaman ◽

AS Durmus ◽

S. Ceribasi ◽

M. Yaman

Keyword(s):

Wound Healing ◽

Nigella Sativa ◽

Silver Sulfadiazine ◽

Control Group ◽

Albino Rats ◽

Burn Wound ◽

Tissue Samples ◽

Burned Areas ◽

Burn Wound Healing ◽

Cold Cream

This experiment was conducted in order to compare the effects of Nigella sativa (NS) and silver sulfadiazine (SSD) cream on healing of burn wounds in rats. Fifty four adult, male Wistar-albino rats were divided into three groups of equal numbers. A burn was generated on the backs of all the rats. The burned areas in the first, second and third groups were covered with daily cold cream (control), SSD cream and NS cream (50% NS oil + 50% cold cream), respectively. Four, nine, and 14 days later, the rats were sacrificed and the burned skin tissue samples were collected for histopathological examinations. Histopatological evaluations on the 4th, 9th and 14th days showed burn healing to be better in the NS and SSD groups with respect to the control group. Wound healing was significantly different among the groups at 4th, 9th and 14th days (P < 0.001). In conclusion, application of NS and SSD cream are effective in healing burn related skin wounds in the rat model.

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