Clinical characteristics of norovirus gastroenteritis among hospitalized children in Japan

Abstract Backgrounds The occurrence of segmental/lobar pattern pneumonia (S/L-PP) in children increases with years. The pathogens of the disease may change for the abuse of antibiotics and the application of vaccines. Therefore, pathogens of S/L-PP in hospitalized children and their association with clinical characteristics may have changed. Objective: To analyze the pathogens of S/L-PP in hospitalized children and their association with clinical characteristics. Methods: The current study analyzed the epidemiological and clinical characteristics of pathogens in children with S/L-PP at a single hospital between 1st Jan 2014 and 31st Dec 2018 retrospectively. The pathogens and their associations with clinical characteristics were statistically analyzed. Results: A total of 593 children with S/L-PP received treatment at a single hospital during the study period by inclusion criteria. 451 patients were single positive for one pathogen and 83 patients had multiple infections. Mycoplasma pneumoniae (M.pneumoniae) (72.34%) was the most commonly detected pathogen, followed by streptococcus pneumoniae (S.pneumoniae) (8.77%). The infection of M.pneumoniae in children with S/L-PP increased with years (p<0.05). The positive rate of M.pneumoniae increased with ages of patients (p<0.05). M.pneumoniae was statistically associated to the extrapulmonary manifestations while S.pneumoniae was statistically associated with abnormal white blood cells (WBCs) and C reactive proteins (CRPs) (p<0.05). Conclusion: M.pneumoniae was the most positive pathogen in children with S/L-PP. The positive rate of M.pneumoniae in children with S/L-PP increased with years and the ages of children. M.pneumoniae was associated with extrapulmonary manifestations while S.pneumoniae was associated with abnormal WBCs and CRPs.

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Clinical characteristics of acute lower respiratory tract infections according to respiratory viruses in hospitalized children without underlying disease during the last 3 years

Yeungnam University Journal of Medicine ◽

10.12701/yujm.2017.34.2.182 ◽

2017 ◽

Vol 34 (2) ◽

pp. 182-190

Author(s):

Min Hae Seo ◽

Hyung Young Kim ◽

Tae Min Um ◽

Hye Young Kim ◽

Hee Ju Park

Keyword(s):

Respiratory Tract ◽

Lower Respiratory Tract ◽

Clinical Characteristics ◽

Respiratory Tract Infections ◽

Respiratory Viruses ◽

Underlying Disease ◽

Hospitalized Children ◽

Lower Respiratory Tract Infections ◽

Tract Infections

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Epidemiology and clinical characteristics of pathogens responsible for the hospitalization of children with segmental/lobar pattern pneumonia

10.21203/rs.2.9678/v2 ◽

2019 ◽

Author(s):

Wang Yanxia ◽

Ma Liji ◽

Li Ying ◽

Yuyun Li ◽

Yanfei Zheng ◽

...

Keyword(s):

Blood Cells ◽

Clinical Characteristics ◽

White Blood Cells ◽

Multiple Infections ◽

Hospitalized Children ◽

Inclusion Criteria ◽

Realtime Pcr ◽

Positive Rate ◽

Single Positive ◽

Microbial Cultivation

Abstract Backgrounds: The occurrence of segmental/lobar pattern pneumonia (S/L-PP) in children has recently increased. The pathogens of the disease may change due to the misuse of antibiotics and the application of vaccines. Therefore, pathogens of S/L-PP in hospitalized children and their association with clinical characteristics may have changed. Objective: To analyze the pathogens of S/L-PP in hospitalized children and their association with clinical characteristics. Methods: The current study analyzed the epidemiological and clinical characteristics of pathogens in children with S/L-PP under 14 years old at a single hospital between 1 st Jan 2014 and 31 st Dec 2018 retrospectively. The pathogens were detected by microbial cultivation, and/or indirect immunofluorescence of the kit (PNEUMOSLIDE IgM), and/or ELISA, and/or realtime PCR in the samples of the patients. Results: A total of 593 children with S/L-PP received treatment at a single hospital during the study period by inclusion criteria. 451 (76.05%) patients were single positive for one pathogen and 83 (14.00%) patients had multiple infections. Mycoplasma pneumoniae ( M.pneumoniae ) (72.34%) was the most frequently identified pathogen, followed by Streptococcus pneumoniae ( S.pneumoniae ) (8.77%). The infection of M.pneumoniae in children with S/L-PP increased with time (p<0.05). The positive rate of M.pneumoniae increased with ages of patients (p<0.05). M.pneumoniae was statistically associated with extrapulmonary manifestations while S.pneumoniae was statistically associated with abnormal white blood cells (WBCs) and C reactive proteins (CRPs) (p<0.05). Conclusion: M.pneumoniae was the most frequently identified pathogen in children with S/L-PP. The positive rate of M.pneumoniae in children with S/L-PP increased with time and the ages of children. M.pneumoniae was associated with extrapulmonary manifestations while S.pneumoniae was associated with abnormal WBCs and CRPs.

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