Oral cyclophosphamide in a case of cyclosporin and steroid-resistant chronic urticaria showing autoreactivity on autologous serum skin testing

2005 ◽  
Vol 30 (5) ◽  
pp. 582-583 ◽  
Author(s):  
R. Asero
Keyword(s):  
Chronic Urticaria ◽  
Skin Testing ◽  
Autologous Serum ◽  
Oral Cyclophosphamide ◽  
Steroid Resistant

scholarly journals Comparative analysis of clinical and laboratory parameters of autoimmune and idiopathic chronic urticaria patients

2021 ◽  
Vol 52 (4) ◽  
pp. 239-248
Author(s):  
Đuka Ninković-Baroš ◽  
Vesna Gajanin ◽  
Bogdan Zrnić ◽  
Živorad Gajanin ◽  
Gordana Katalina
Keyword(s):  
Comparative Analysis ◽  
Chronic Urticaria ◽  
Skin Testing ◽  
Autologous Blood ◽  
Autologous Serum ◽  
Autoimmune Thyroid Diseases ◽  
Group I ◽  
Autoimmune Urticaria ◽  
Significant Difference ◽  
Serum Test

Background: According to the cause, chronic urticaria is most frequently divided into autoimmune and idiopathic urticaria. Aim of the paper was to determine the frequency of autoimmune urticaria using autologous serum skin testing and a comparative analysis of chronic idiopathic and chronic autoimmune urticaria by disease course, severity and most common comorbidities. Methods: Analysis covered 64 adult patients of both sexes with chronic urticaria, divided into two groups according to their positivity in autologous serum skin testing (group I with positive test and group II with negative test). General haematological and biochemical parameters, antithyroid antibodies, hepatitis serum markers, Helicobacter pylori and Borrelia burgdorferi antibodies were performed for patients in both groups. First group patients were treated by autologous blood therapy (autohaemotherapy). The analytical statistical tool SPSS (Statistical Product and Service Solutions) version 20 for descriptive statistics and statistical methods was used. The significance level used was p = 0.05. Results: The frequency of positive autologous serum test in total population of patients with chronic urticaria was 43.8 %. The average duration of urticaria was 20 months in both groups. Statistically significant difference was found in weekly scores between the studied groups (p = 0.032) in favour of chronic autoimmune urticaria with a positive autologous serum test. Subjects with chronic autoimmune urticaria had a significantly higher association with autoimmune thyroid diseases. Conclusions: Direct relation was established between the use of autologous blood therapy in patients with autoimmune chronic urticaria and improvement of the clinical picture.

scholarly journals Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria

2017 ◽  
Vol 15 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Dharmendra Karn ◽  
Shekhar KC
Keyword(s):  
Skin Prick Test ◽  
Chronic Urticaria ◽  
Statistical Significance ◽  
Cost Effective ◽  
Chronic Idiopathic Urticaria ◽  
Autologous Serum ◽  
P Value ◽  
Prick Test ◽  
H1 Antihistamines ◽  
Serum Therapy

Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status.Methods: Untreated 102 patients of chronic urticaria were enrolled in a non-randomized interventional study. Patients were categorized into two groups based on autologous serum skin prick test as test positive (ASST +) and test negative (ASST -). Patients were then treated with intramuscular injection of 0.05ml per kg body weight of autologous serum weekly for 10 weeks. Urticaria activity scoring (UAS) tool was used for quantification of the symptoms. Weekly recording of UAS (range: 0-42) was made before the therapy (baseline) and during the therapy for 10 weeks.Results: Significant improvement with AST in the mean UAS was noted from baseline to 10 weeks in both the group of patients (14.6 ± 6.3 and 10.2 ± 5.1 for ASST+ group; 16.9 ± 7.8 and 8.6 ± 4.8 for ASST- group; at baseline and 10 weeks, respectively (p-value for both <0.05)). However no statistical significance was found while comparing the efficacy of the therapy against ASST + and ASST - Groups (p-value > 0.05).Conclusions: Irrespective of autologous skin prick test results, autologous serum therapy showed significant improvement in patients with chornic idiopathic urticaria. AST can, thus, be an effective treatment modality for it.

scholarly journals EFFECTIVENESS OF AUTOLOGOUS SERUM THERAPY IN CHRONIC URTICARIA: A PROSPECTIVE OBSERVATIONAL STUDY IN TERTIARY CARE HOSPITAL

2016 ◽  
Vol 5 (17) ◽  
pp. 822-827
Author(s):  
Rakesh Kumar Patel ◽  
Anil Kumar Gupta ◽  
Santosh Kumar Singh ◽  
Harleen Chhachhi ◽  
Pawan Kumar Patel ◽  
...  
Keyword(s):  
Observational Study ◽  
Chronic Urticaria ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Autologous Serum ◽  
Care Hospital ◽  
Serum Therapy

scholarly journals Autologous serum therapy in chronic urticaria: Old wine in a new bottle

2008 ◽  
Vol 74 (2) ◽  
pp. 109 ◽  
Author(s):  
AK Bajaj ◽  
Abir Saraswat ◽  
Amitabh Upadhyay ◽  
Rajetha Damisetty ◽  
Sandipan Dhar
Keyword(s):  
Chronic Urticaria ◽  
Autologous Serum ◽  
Serum Therapy

The autologous serum skin test in the follow-up of patients with chronic urticaria

Allergy ◽  
2005 ◽  
Vol 60 (2) ◽  
pp. 256-258 ◽  
Author(s):  
A. Fusari ◽  
C. Colangelo ◽  
F. Bonifazi ◽  
L. Antonicelli
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Autologous Serum ◽  
Autologous Serum Skin Test

scholarly journals Autologous Serum Skin Test for Initial Identification of Auto- Antibodies in Chronic Urticaria

2018 ◽  
Vol 19 (2) ◽  
pp. 100-103
Author(s):  
Mohammad Nura Alam ◽  
Mohammad Ali ◽  
Mohammad Moniruzzaman Khan ◽  
Keya Tarafder ◽  
Goutam Kumar Acherjya ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Cost Effective ◽  
Autologous Serum ◽  
P Value ◽  
Effective Measure ◽  
Autologous Serum Skin Test ◽  
Physical Urticaria ◽  
Retrospective Data Analysis ◽  
Initial Identification

Background: Autologous serum skin test (ASST) is easy to perform, cost effective measure for initial identification of auto-antibody in patients suffering from chronic urticaria which may occur due to autoimmune trigger by spontaneously developed auto-antibodies against FcμRI receptor of skin mast cells.Objective: This review is designed to see the positivity of ASST in patients suffering from chronic urticaria.Materials & Methods: This a retrospective data analysis conducted from the records of patients suffered from at least two episodes of urticaria or more in a week for 6 weeks and who did ASST aged more than 10 years between July 2015 to June 2017. These subjects were not pregnant or lactating mother, did not had urticarial vasculitis, predominant co-existing physical urticaria and had negative Hepatitis B antigen and anti-nuclear antibody reports.Results: Total 53 were included in this study of them 33 were female. Mean age was 32 years with a standard deviation (SD) of 11 years. Among study patients 16 (30.2% of total) had a positive ASST result. No age or sex difference was observed in positive ASST cases. In positive cases significant (p-value:<0.001) mean induration difference of 2.75mm with a SD of 1.00 mm observed than induration produced by negative control.Conclusion: ASST is easy and effective tool for initial identification of auto-reactive urticaria.J MEDICINE JUL 2018; 19 (2) : 100-103

Autologous Whole Blood Injections to Patients with Chronic Urticaria and a Positive Autologous Serum Skin Test: A Placebo-Controlled Trial

Dermatology ◽  
2006 ◽  
Vol 212 (2) ◽  
pp. 150-159 ◽  
Author(s):  
P. Staubach ◽  
K. Onnen ◽  
A. Vonend ◽  
M. Metz ◽  
F. Siebenhaar ◽  
...  
Keyword(s):  
Skin Test ◽  
Chronic Urticaria ◽  
Whole Blood ◽  
Controlled Trial ◽  
Autologous Serum ◽  
Autologous Serum Skin Test ◽  
Autologous Whole Blood

scholarly journals HLA among Brazilian patients with spontaneous chronic urticaria and positive autologous serum skin test

2012 ◽  
Vol 87 (4) ◽  
pp. 578-583 ◽  
Author(s):  
Zamir Calamita ◽  
Andrea Bronhara Pelá ◽  
Márcia Gamberini ◽  
Wilson Baleotti Júnior ◽  
Odilon Marques de Almeida Filho ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Skin Test ◽  
Chronic Urticaria ◽  
Population Group ◽  
Autologous Serum ◽  
Major Histocompatibility ◽  
Allele Distribution ◽  
Autologous Serum Skin Test ◽  
Histocompatibility Complex ◽  
Oligonucleotide Hybridization

BACKGROUND: An association between class I and II alleles of the major histocompatibility complex and idiopathic chronic urticaria has previously been observed in different populations, but there are still no studies on Brazilian populations in this regard. OBJECTIVE: The involvement of the major histocompatibility complex classes I and II (loci A, B and DR) in Brazilian patients with idiopathic chronic urticaria and a positive autologous serum skin test was investigated and compared with a healthy population group. METHODS: DNA was extracted from the blood of 42 patients with idiopathic chronic urticaria and major histocompatibility complex classes I and II alleles were determined using the polymerase chain reaction and a laboratory test for oligonucleotide hybridization using a single-filament probe. The frequencies of these alleles in patients with chronic urticaria were compared with the frequencies in 1000 genetically unrelated voluntary blood donors from the same region of Brazil. The diagnosis of idiopathic chronic urticaria was based on the patients' clinical history and routine laboratory tests. Only the patients with positive autologous serum skin test were selected. The allele distribution resulted from the patient and control groups were analyzed using odds ratios and 95% confidence intervals. RESULTS: No statistically significant differences were found between the positive autologous serum skin test patients with chronic urticaria and the control group. CONCLUSIONS: We found that in this population group, there was no specific association between the HLA alleles studied and chronic urticaria. We believe that further population studies are needed in order to investigate the possible existence of this association.

Sign in / Sign up

Export Citation Format

Share Document