scholarly journals Expression of decay-accelerating factor is reduced on hyperplastic synovial lining cells in rheumatoid synovitis

2008 ◽  
Vol 83 (3) ◽  
pp. 364-368 ◽  
Author(s):  
J. ITOH ◽  
M. NOSE ◽  
T. FUJITA ◽  
M. KATO ◽  
A. OHYAMA ◽  
...  
Keyword(s):  
Synovial Lining ◽  
Decay Accelerating Factor ◽  
Synovial Lining Cells

Expression of decay-accelerating factor on synovial lining cells in inflammatory and degenerative arthritides

1992 ◽  
Vol 12 (5) ◽  
pp. 201-205 ◽  
Author(s):  
A. Tarkowski ◽  
C. Trollmo ◽  
P. S. Seifert ◽  
G. K. Hansson
Keyword(s):  
Synovial Lining ◽  
Decay Accelerating Factor ◽  
Synovial Lining Cells

Synovial lining cells

1989 ◽  
Vol 9 (2) ◽  
pp. 49-51 ◽  
Author(s):  
P. A. Revell
Keyword(s):  
Synovial Lining ◽  
Synovial Lining Cells

Differences in the Redox Balance in Human Rheumatoid and Non-rheumatoid Synovial Lining Cells

1973 ◽  
Vol 148 (3) ◽  
pp. 265-274 ◽  
Author(s):  
R.G. Butcher ◽  
Lucille Bitensky ◽  
B. Cashman ◽  
J. Chayen
Keyword(s):  
Redox Balance ◽  
Synovial Lining ◽  
Synovial Lining Cells

Fibroblastic Synovial Lining Cells (Synoviocytes)

1995 ◽  
pp. 153-161 ◽  
Author(s):  
J.C.W. Edwards
Keyword(s):  
Synovial Lining ◽  
Synovial Lining Cells

scholarly journals Biologically active thrombomodulin is synthesized by adherent synovial fluid cells and is elevated in synovial fluid of patients with rheumatoid arthritis

Blood ◽  
1993 ◽  
Vol 81 (3) ◽  
pp. 726-733 ◽  
Author(s):  
EM Conway ◽  
B Nowakowski
Keyword(s):  
Rheumatoid Arthritis ◽  
Synovial Fluid ◽  
Protein C ◽  
Inflammatory Process ◽  
Biologically Active ◽  
Northern Analysis ◽  
Synovial Lining ◽  
Local Synthesis ◽  
Synovial Lining Cells ◽  
Synovial Fluid Cells

Abstract Thrombomodulin (TM) is a transmembrane glycoprotein that interacts with thrombin, thereby serving as a cofactor in the activation of protein C, a major physiologically relevant natural anticoagulant. Although initially described as a vascular endothelial cell receptor, TM has also been reported to be synthesized by several cells, including megakaryocytes, platelets, monocytes, neutrophils (PMN), mesothelial cells, and synovial lining cells. A prominent feature of rheumatoid arthritis (RA) is infiltration of PMN into the joint space. To determine whether TM might play a role in the inflammatory process, we examined synovial fluid for the presence of TM in 10 patients with RA and five patients with osteoarthritis (OA). We determined that the mean synovial fluid and plasma TM levels in the OA group were 23.5 ng/mL and 24.2 ng/mL, respectively, whereas those with RA had a significantly elevated mean synovial fluid TM level of 136.2 ng/mL as compared with the plasma TM concentration of 43.9 ng/mL (P < .05). Synovial fluid TM levels did not correlate with PMN counts (r = .261). Purified TM from synovial fluid was identical in molecular weight to plasma-derived TM and was biologically functional with respect to protein C cofactor activity. Using direct immunofluorescence, we determined that adherent cultured synovial fluid cells that are not monocytoid in origin express surface and cytoplasmic TM, thereby providing an alternative source of the protein. Biologic activity of the cell-surface TM was confirmed by acceleration of thrombin-dependent protein C activation. Northern analysis of RNA extracted from the cultured cells indicated that TM messenger RNA was present, suggesting local synthesis. Our results indicate that in RA-associated synovial effusions, biologically active TM is increased, the source of which may be from plasma, PMN, and/or synovial lining cells. TM may play a regulatory role either in fibrin deposition in the inflamed joint and/or in the progression of the inflammatory process.

Metabolism of Rheumatoid and Non-Rheumatoid Synovial Lining Cells

2015 ◽  
pp. 59-74 ◽  
Author(s):  
J. Chayen ◽  
Lucille Bitensky
Keyword(s):  
Synovial Lining ◽  
Synovial Lining Cells

NF-κB Activation and iNOS Expression in the Synovial Membrane of Rat Temporomandibular Joints after Induced Synovitis

2003 ◽  
Vol 82 (3) ◽  
pp. 183-188 ◽  
Author(s):  
T. Yamaza ◽  
K.F. Masuda ◽  
Y. Tsukiyama ◽  
K. Nishijima ◽  
R. Murakami ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Transcription Factors ◽  
Inos Expression ◽  
Synovial Lining ◽  
Temporomandibular Joints ◽  
Synovial Lining Cells ◽  
Oxide Synthase ◽  
And Control ◽  
Southwestern Histochemistry ◽  
Inducible Nitric Oxide

NF-κB plays a pivotal role in pathogenesis in general arthritis. However, the participation of NF-κB in inflammation of the temporomandibular joint (TMJ) is poorly understood. We examined NF-κB expression in rat TMJs with synovitis induced by condyle hypermobility. By immunohistochemistry, NF-κB immunoreactivity was found mainly in the cytoplasm, not the nucleus, of the synovial lining cells of induced-synovitis and control TMJs. Southwestern histochemistry, a new method for detecting transcription factors, showed greater NF-κB expression in the nucleus of the synovial lining cells in the hypertrophic synovium than in control synovium. Increased numbers of the synovial lining cells with immunoreactivity for inducible nitric oxide synthase (iNOS), which is transcriptionally regulated by NF-κB, were also seen in the inflamed synovium. These findings indicate that excess mechanical stress increases NF-κB activation in the TMJ and suggest that active NF-κB is involved in the progression of TMJ inflammation.

scholarly journals Origin of Non-Haematogenous Synovial Lining Cells in Inflammatory Hyperplasia

1988 ◽  
Vol 81 (3) ◽  
pp. 185-185
Author(s):  
J T Beranek
Keyword(s):  
Synovial Lining ◽  
Synovial Lining Cells

scholarly journals Localization of Cathepsins B and D in the Synovial Lining Cells of the Normal Rat Temporomandibular Joint by Immuno-light and -electron Microscopy.

1994 ◽  
Vol 27 (5) ◽  
pp. 441-450 ◽  
Author(s):  
TAMOTSU KIYOSHIMA ◽  
MIZUHO A. KIDO ◽  
TAKAYUKI TSUKUBA ◽  
HIDETAKA SAKAI ◽  
KENJI YAMAMOTO ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Temporomandibular Joint ◽  
Light And Electron Microscopy ◽  
Synovial Lining ◽  
Synovial Lining Cells ◽  
Normal Rat

Immunocytochemical localization of cathepsin L in the synovial lining cells of the rat temporomandibular joint

1994 ◽  
Vol 39 (12) ◽  
pp. 1049-1056 ◽  
Author(s):  
T. Kiyoshima ◽  
M.A. Kido ◽  
Y. Nishimura ◽  
M. Himeno ◽  
T. Tsukuba ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Cathepsin L ◽  
Immunocytochemical Localization ◽  
Synovial Lining ◽  
Synovial Lining Cells
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