Asymmetric dimethylarginine as a risk factor for cardiovascular disease in Japanese patients with type 2 diabetes mellitus

2011 ◽  
Vol 74 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Ippei Kanazawa ◽  
Shozo Yano ◽  
Yoshitomo Notsu ◽  
Toru Yamaguchi ◽  
Toru Nabika ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Asymmetric Dimethylarginine ◽  
Japanese Patients

scholarly journals Home Blood Pressure Measurement in the Morning Related to Cancer in Patients with Type 2 Diabetes Mellitus: 10 Years-Term Results of a Longitudinal Study and Cancer

2015 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Kyuzi Kamoi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Cause Of Death ◽  
Japanese Patients ◽  
Pressure Measurements ◽  
Significant Difference

Previous longitudinal studies have demonstrated that blood pressure measurements at home (HBP) in the wakening- up display stronger predictive power for death, and vascular complications in patients with type 2 diabetes mellitus (T2DM) than clinic blood pressure measurements (CBP). The leading cause of death was cancer. Patients with T2DM have associated with cancer, and high CBP is a risk factor for cancer. Therefore, this study investigated whether HBP or CBP is related to cancer event in patients with T2DM for 10 years. At baseline, 400 Japanese patients with T2DM were classified as hypertensive (HT) or normotensive (NT) based on HBP and CBP. Mean (± SD) duration was 95 ± 35 months. Primary and secondary endpoints were death and cancer, respectively. Differences in outcome between HT and NT were analyzed using survival curves from Kaplan-Meier analysis and log-rank testing. Associated risk factors were assessed using Cox proportional hazards. On basis of HBP, death and event of cancer were significantly higher in HT than in NT. The leading cause of death was cancer. On basis of CBP, there was no significant difference in the incidence of death and event of cancer between patients with HT and NT at baseline. Associated risk factor for cancer was T2DM. Home morning HT may be reflected more keenly state of cancer than clinic HT, which may be superior to clinic NT. When we meet with such patients, it is important that cancer may be one of many causes for morning HT in Japanese patients with T2DM.

scholarly journals Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus

2013 ◽  
Vol 169 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Shinya Furukawa ◽  
Isao Saito ◽  
Shin Yamamoto ◽  
Teruki Miyake ◽  
Teruhisa Ueda ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Intermittent Hypoxia ◽  
Surrogate Marker ◽  
Japanese Patients ◽  
Sleep Apnoea ◽  
Obstructive Sleep

ObjectiveWe estimated the prevalence of nocturnal intermittent hypoxia, a surrogate marker of obstructive sleep apnoea, among type 2 diabetes mellitus (T2DM) patients and examined the association between nocturnal intermittent hypoxia and microvascular diseases.Design and methodsWe recruited 513 Japanese patients (292 men and 221 women) with T2DM. Nocturnal intermittent hypoxia was diagnosed using the 3% oxygen desaturation index, with less than five events per hour corresponding to normal and five events or more per hour corresponding to nocturnal intermittent hypoxia.ResultsThe prevalence of nocturnal intermittent hypoxia was 45.4% among T2DM patients. The nocturnal intermittent hypoxia group was older and had a higher BMI, greater weight change since the age of 20 years, higher smoking rate and increased prevalence of hypertension, hyperlipidaemia, microalbuminuria and macroalbuminuria. Microalbuminuria (model 1: odds ratio (OR), 3.41; 95% CI, 1.85–6.40; model 2: OR, 3.69; 95% CI, 1.85–7.59 and model 3: OR, 3.12; 95% CI, 1.45–6.95) and nephropathy (model 1: OR, 4.51; 95% CI, 1.58–15.1; model 2: OR, 7.31; 95% CI, 2.11–31.6 and model 3: OR, 5.23; 95% CI, 1.45–23.8) were derived as factors from all the three statistical models and constantly associated with nocturnal intermittent hypoxia only in women.ConclusionsNocturnal intermittent hypoxia was highly prevalent among T2DM patients and may be an independent associated risk factor for microalbuminuria in Japanese women with T2DM.

scholarly journals Plasma Level of Urate among Sudanese with Type 2 Diabetes in Khartoum state, Sudan.

2014 ◽  
Vol 2 (12) ◽  
pp. 24-29
Author(s):  
Salma Hussein Elhassan ◽  
Bader Eldien Hassan Elabid ◽  
Sara osman Yousif
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Plasma Level ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Plasma Urate

Background: Type 2 diabetes mellitus is an independent risk factor for cardiovascular disease and the risk for cardiovascular disease is increased three to four fold in type 2 diabetes mellitus as compared to non-diabetic population. Hyperuricaemia has been reported to be a potential risk factor for cardiovascular disease in type 2 diabetes mellitus. The objective of this study was to assess the plasma level of urate in Sudanese patients with type 2 diabetes in comparison with apparently healthy (non-diabetic) volunteers as controls.Methods: This is a descriptive, cross- sectional and hospital-based study conducted during the period from March to May 2011 in Jabir Abu Elez diabetic center and Nurein medical center, both in Khartoum state, Sudan. The study group included 52 NIDDM cases and 30 healthy controls of either sex matched for age and gender. Fasting venous samples were collected from both cases and controls. Serum levels of uric acid, and lipid profile were assayed using commercial reagent kits from Biosystem Company.Results: In the current study there was a significant increase in plasma urate in type 2 diabetic patients as compared to the control group. There was a significant increase in lipid profile with exception to high density lipoprotein which was significantly reduced. There was insignificant correlation of plasma urea, and lipid profile with both; body mass index and the duration of diabetes.Conclusion: Hyperuricemia is significantly associated with type 2 diabetes mellitus and can increase the morbidity and mortality of diabetes if not managed in time. Elevated plasma urate levels are associated with increased risk of cardiovascular mortality in type 2 diabetes.

scholarly journals HbA1c is a risk factor for cardiovascular disease in association with oxidative stress in patients with type 2 diabetes mellitus

2017 ◽  
Vol 5 (7) ◽  
pp. 3114 ◽  
Author(s):  
Siva Prasad Palem
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Healthy Controls ◽  
High Level ◽  
Type 2 Diabetic

Background: Cardiovascular disease (CVD) is a major cause of death in diabetic subjects. Glycaemic status is one of the vital factor involved in vascular complications. It was clear the effect of glycaemia on microvascular complications, but uncertain on macrovascular complications. As we know oxidative stress plays a major role in the development of atherosclerosis and cardiovascular disease. Since oxidative stress is a risk factor for cardiovascular disease, the study has designed to perceive an association between HbA1c and oxidative stress in patients with type 2 diabetes mellitus for early prediction of cardiovascular events.Methods: 120 subjects were taken into the study, among these 60 type 2 diabetic subjects and remaining 60 subjects were healthy controls. The parameters like HbA1c, MDA and FRAP were estimated by established methods. ‘Kruskal Wallis’ test was used for variables in the parameters and Pearson correlation test was used to perform correlation between HbA1c and oxidative stress.Results: High level of HbA1c and MDA, low level of FRAP were found in patients with type 2 diabetes than healthy controls. The study was also found HbA1c have positive association with malondialdehyde (MDA) and negative association with FRAP.Conclusions: HbA1c was positively associated with oxidative stress in patients with type 2 diabetes mellitus. In this scenario, type 2 diabetic patients with high level of HbA1c might have risk of cardiovascular events.

Sign in / Sign up

Export Citation Format

Share Document