The relationship of serum total sialic acid with serum acute phase proteins and lipoprotein (a) in patients with severe hypertriglyceridaemia

1994 ◽  
Vol 24 (3) ◽  
pp. 179-181 ◽  
Author(s):  
M. CROOK ◽  
S. HAQ ◽  
M. HAQ ◽  
P. TUTT
Author(s):  
M Haq ◽  
S Haq ◽  
P Tutt ◽  
M Crook

Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in SO normal individuals (24 male) and IS subjects (12 male) who had experienced a myocardial infarct. The mean serum TSA in the normal individuals was 2·05 SD 0·38 mmol/L (range 1·16–2·74) and the mean serum LASA was 0.70 SD 0·19 mmol/L (range 0·23–1·03). We also measured five serum acute phase proteins and found a good correlation between these and serum TSA: C-reactive protein, r = 0.52, P<0.001, α-1-antichymotrypsin, r=0·79, P<0·0001, α-2-macroglobulin, r=0·38, P<0·01 and α-1-acid glycoprotein, r=0·32, P<0·05. A significant correlation between plasma TSA and plasma C-reactive protein ( r = 0·47, P<0·04) and also Fibrinogen ( r=0·53, P<0·04) was noted on day one following the myocardial infarction, whereas a significant correlation between plasma TSA and plasma α-1-antichymotrypsin ( r=0·51, P<0·03) and also plasma α-1-acid glycoprotein ( r=0·64, P<0·05) was found on day two following the infarction. Thus it would seem that serum TSA is at least in part related to some of the acute phase proteins in both healthy individuals and those having had a myocardial infarction.


2009 ◽  
Vol 20 (1) ◽  
pp. 69-73 ◽  
Author(s):  
S. Nazifi ◽  
M. R. Tabande ◽  
S. A. Hosseinian ◽  
M. Ansari-Lari ◽  
H. Safari

1993 ◽  
Vol 223 (1-2) ◽  
pp. 73-82 ◽  
Author(s):  
Thomas B. Ledue ◽  
Louis M. Neveux ◽  
Glenn E. Palomaki ◽  
Robert F. Ritchie ◽  
Wendy Y. Craig

1994 ◽  
Vol 224 (2) ◽  
pp. 199-201 ◽  
Author(s):  
M.A. Crook ◽  
S. Haq ◽  
G. Chusney ◽  
M. Haq ◽  
P. Tutt

1993 ◽  
Vol 4 (6) ◽  
pp. 484-489 ◽  
Author(s):  
Bernice R. Zysow ◽  
Richard M. Lawn

2003 ◽  
Vol 4 (2) ◽  
pp. 73
Author(s):  
E. Liberopoulos ◽  
C. Tzallas ◽  
E. Bairaktari ◽  
M. Elisaf

Sign in / Sign up

Export Citation Format

Share Document