scholarly journals Treatment of water-based metalworking fluids to prevent hypersensitivity pneumonitis associated with Mycobacterium spp.

2007 ◽  
Vol 0 (0) ◽  
pp. 071027034549002-???
Author(s):  
K. Steinhauer ◽  
P. Goroncy-Bermes
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids ◽  
Water Based ◽  
Mycobacterium Spp

scholarly journals Factors Influencing the Microbial Composition of Metalworking Fluids and Potential Implications for Machine Operator's Lung

2011 ◽  
Vol 78 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Jean-Benjamin Murat ◽  
Frédéric Grenouillet ◽  
Gabriel Reboux ◽  
Emmanuelle Penven ◽  
Adam Batchili ◽  
...  
Keyword(s):  
Metal Cutting ◽  
Hypersensitivity Pneumonitis ◽  
Environmental Parameters ◽  
Metalworking Fluids ◽  
Microbial Composition ◽  
Gram Positive ◽  
Gram Negative ◽  
Content Type ◽  
Kinetics Of

ABSTRACTHypersensitivity pneumonitis, also known as “machine operator's lung” (MOL), has been related to microorganisms growing in metalworking fluids (MWFs), especiallyMycobacterium immunogenum. We aimed to (i) describe the microbiological contamination of MWFs and (ii) look for chemical, physical, and environmental parameters associated with variations in microbiological profiles. We microbiologically analyzed 180 MWF samples from nonautomotive plants (e.g., screw-machining or metal-cutting plants) in the Franche-Comté region in eastern France and 165 samples from three French automotive plants in which cases of MOL had been proven. Our results revealed two types of microbial biomes: the first was from the nonautomotive industry, showed predominantly Gram-negative rods (GNR), and was associated with a low risk of MOL, and the second came from the automotive industry that was affected by cases of MOL and showed predominantly Gram-positive rods (GPR). Traces ofM. immunogenumwere sporadically detected in the first type, while it was highly prevalent in the automotive sector, with up to 38% of samples testing positive. The use of chromium, nickel, or iron was associated with growth of Gram-negative rods; conversely, growth of Gram-positive rods was associated with the absence of these metals. Synthetic MWFs were more frequently sterile than emulsions. Vegetable oil-based emulsions were associated with GNR, while mineral ones were associated with GPR. Our results suggest that metal types and the nature of MWF play a part in MWF contamination, and this work shall be followed by furtherin vitrosimulation experiments on the kinetics of microbial populations, focusing on the phenomena of inhibition and synergy.

scholarly journals Hypersensitivity pneumonitis and metalworking fluids contaminated by mycobacteria

2011 ◽  
Vol 38 (2) ◽  
pp. 486-487 ◽  
Author(s):  
C. M. Barber ◽  
C. Burton ◽  
E. Robinson ◽  
B. Crook ◽  
G. Evans ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids

Patch testing with components of water-based metalworking fluids: results of a multicentre study with a second series

2006 ◽  
Vol 55 (6) ◽  
pp. 322-329 ◽  
Author(s):  
Johannes Geier ◽  
Holger Lessmann ◽  
Detlef Becker ◽  
Magnus Bruze ◽  
Peter J. Frosch ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Patch Testing ◽  
Metalworking Fluids ◽  
Water Based

Hypersensitivity pneumonitis in a cystic fibrosis patient

2019 ◽  
Author(s):  
A P Bellanger ◽  
H Morisse-Pradier ◽  
G Reboux ◽  
E Scherer ◽  
S Pramil ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Cystic Fibrosis Patient ◽  
Pulmonary Disease ◽  
Hypersensitivity Pneumonitis ◽  
Metalworking Fluids ◽  
Aetiological Agent ◽  
Pseudomonas Oleovorans ◽  
Inflammatory Lung Disease

Abstract Hypersensitivity pneumonitis (HP) is a chronic inflammatory lung disease caused by repeated inhalation of antigenic substances. We present a case of metalworking fluids (MWFs)-HP sensitized to Pseudomonas oleovorans in a cystic fibrosis patient. This case illustrates that HP diagnosis remains challenging, especially in patients with another pulmonary disease, and that serodiagnosis contributes to identifying the precise microorganism involved. It also demonstrates that P. oleovorans is an important secondary aetiological agent in MWF-HP, less known than Mycobacterium immunogenum.

Impact of Supercritical Carbon Dioxide Metalworking Fluids on Tool Life in Turning of Sintered Steel and Milling of Compacted Graphite Iron

2009 ◽  
Author(s):  
Douglas J. MacLean ◽  
Kim F. Hayes ◽  
Thomas Barnard ◽  
Timothy Hull ◽  
Ye Eun Park ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Tool Wear ◽  
Cutting Forces ◽  
Metalworking Fluids ◽  
Compacted Graphite Iron ◽  
Sintered Steel ◽  
Compacted Graphite ◽  
Metalworking Fluid ◽  
Water Based

This paper investigates the influence of supercritical carbon dioxide (scCO2) metalworking fluids on tool wear in two automotive manufacturing processes. scCO2 is a low-cost minimum quantity lubrication (MQL) system with excellent cooling characteristics. In valve seat machining of sintered steel with cubic boron nitride (CBN) inserts, scCO2 reduced tool wear by up to 25% and cutting forces by 10% when compared with the benchmark water-based flood metalworking fluid currently used in production operations. In end milling of compacted graphite iron (CGI) with uncoated carbide inserts, scCO2 reduced tool wear by up to 50% when compared with the currently used metalworking fluid. These results are consistent with those from other applications that show scCO2-based metalworking fluids have the potential to reduce tool wear and cutting forces when compared with commonly used water-based metalworking fluids. At the same time scCO2 is environmentally benign, eliminates metalworking fluid maintenance and disposal, and removes the major health risks associated with today’s metalworking fluids.

scholarly journals Presence of a Single Genotype of the Newly Described Species Mycobacterium immunogenum in Industrial Metalworking Fluids Associated with Hypersensitivity Pneumonitis

2002 ◽  
Vol 68 (11) ◽  
pp. 5580-5584 ◽  
Author(s):  
Richard J. Wallace, ◽  
Yansheng Zhang ◽  
Rebecca W. Wilson ◽  
Linda Mann ◽  
Harold Rossmoore
Keyword(s):  
Genomic Dna ◽  
Hypersensitivity Pneumonitis ◽  
The United States ◽  
Clinical Isolates ◽  
Metalworking Fluids ◽  
Enzyme Analysis ◽  
Restriction Enzyme Analysis ◽  
Clinical Patient ◽  
Industrial Sites ◽  
Single Genotype

ABSTRACT Outbreaks of hypersensitivity pneumonitis (HP) among industrial metal-grinding machinists working with water-based metalworking fluids (MWF) have frequently been associated with high levels of mycobacteria in the MWF, but little is known about these organisms. We collected 107 MWF isolates of mycobacteria from multiple industrial sites where HP had been diagnosed and identified them to the species level by a molecular method (PCR restriction enzyme analysis [PRA]). Their genomic DNA restriction fragment length polymorphism (RFLP) patterns, as determined by pulsed-field gel electrophoresis (PFGE), were compared to those of 15 clinical (patient) isolates of the recently described rapidly growing mycobacterial species Mycobacterium immunogenum. A total of 102 of 107 (95%) MWF isolates (from 10 industrial sites within the United States and Canada) were identified as M. immunogenum and gave PRA patterns identical to those of the clinical isolates. Using genomic DNA, PFGE was performed on 80 of these isolates. According to RFLP analysis using the restriction enzymes DraI and XbaI, 78 of 80 (98%) of the MWF isolates represented a single clone. In contrast, none of the 15 clinical isolates had genetic patterns the same as or closely related to those of any of the others. Given the genomic heterogeneity of clinical isolates of M. immunogenum, the finding that a single genotype was present at all industrial sites is remarkable. This suggests that this genotype possesses unusual features that may relate to its virulence and its potential etiologic role in HP and/or to its resistance to biocides frequently used in MWF.

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