Quality of life in cervical cancer patients treated with radiation therapy

2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
Małgorzata Pasek ◽  
Lilia Suchocka ◽  
Krzysztof Urbański
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Radiation Therapy ◽  
Cancer Patients

scholarly journals Predictive factors of posttreatment fracture by definitive radiotherapy for uterine cervical cancer

2020 ◽  
Author(s):  
Kazuki Ishikawa ◽  
Tsuneo Yamashiro ◽  
Takuro Ariga ◽  
Takafumi Toita ◽  
Wataru Kudaka ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Risk Factors ◽  
Cervical Cancer ◽  
Multivariate Analysis ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Clinical Characteristics ◽  
Univariate Analysis ◽  
Uterine Cervical Cancer

Abstract Purpose Fractures are known to shorten life expectancy and worsen the quality of life. The risk of fractures after radiation therapy in cervical cancer patients is known to be multifactorial. In this study, we examined risk factors for fractures in cervical cancer patients, especially by evaluating bone densities and DVH parameters for fractured bones. Materials and Methods For 42 patients, clinical characteristics, pretreatment CT bone densities, and radiation dose were compared between patients with and without fractures. Results Posttreatment fractures occurred in 25 bones among ten patients. Pretreatment CT bone densities were significantly lower in patients with fractures (P < 0.05–0.01 across sites, except for the ilium and the ischium). Although DVH parameters were also significantly associated with fractures in univariate analysis, only CT densities were significantly associated with fractures in multivariate analysis. Conclusion Pretreatment CT densities of spinal and pelvic bones, which may reflect osteoporosis, have a significant impact on the risk for posttreatment fractures.

scholarly journals Five-year quality of life of endometrial cancer patients treated in the randomised Post Operative Radiation Therapy in Endometrial Cancer (PORTEC-2) trial and comparison with norm data

2012 ◽  
Vol 48 (11) ◽  
pp. 1638-1648 ◽  
Author(s):  
Remi A. Nout ◽  
Hein Putter ◽  
Ina M. Jürgenliemk-Schulz ◽  
Jan J. Jobsen ◽  
Ludy C.H.W. Lutgens ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Endometrial Cancer ◽  
Cancer Patients

scholarly journals Vesicovaginal Fistula After Fourteen Years of Pelvic Radiation

2018 ◽  
Vol 13 (2) ◽  
pp. 60-62
Author(s):  
Kenusha Devi Tiwari ◽  
Aruna Karki ◽  
Ganesh Dangal ◽  
Hema Pradhan ◽  
Ranjana Shrestha ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cervical Cancer ◽  
Radiation Therapy ◽  
Radical Hysterectomy ◽  
Vesicovaginal Fistula ◽  
Fistula Repair ◽  
Pelvic Radiation ◽  
Advanced Cervical Carcinoma

Radiation therapy is an effective treatment for cervical cancer. However, of various complications, irradiation sometimes can cause formation of fistula between vagina and bladder and or rectum compromising the quality of life. Pelvic radiation is the primary cause of delayed vesicovaginal fistula with incidence of 13% in well-resourced countries and 0.2% in low resourced countries. Majority of them become apparent 1.5-2 years after completion of radiotherapy and can occur even up-to 20-30 years after the original insult. A 63 years’ female visited our outpatient department for involuntary loss of urine per vagina for 1.5 years. She had undergone radical hysterectomy and radiotherapy 16 years ago for an advanced cervical carcinoma. With positive dye test, she had vesicovaginal fistula with Goh classification of 1biii. She underwent simple fistula repair via vaginal approach. After three weeks of catheterization, successful closure was achieved.

Reversal of anorexia with megestrol acetate (MA): Impact on quality of life (QoL) in non-metastasic lung cancer patients (pts) undergoing radiation therapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 18613-18613 ◽  
Author(s):  
J. Pardo ◽  
A. Mena ◽  
A. Monleon ◽  
V. Macias ◽  
J. Sole ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Life Questionnaire ◽  
Negative Effects ◽  
Lung Cancer Patients ◽  
Related Quality ◽  
The Difference

18613 Background: Anorexia is a common and major problem in cancer patients. Its ethiology is multifactorial and has negative effects on pts QoL. Up to 30% of non-metastasic lung cancer pts receiving radiotherapy will develop anorexia during treatment. We conducted a randomized trial comparing the efficacy of two different doses of MA. The results of the first 130 pts included, presented at ASCO 2003, indicated that MA at doses of 600 mg/day is significantly more effective in the treatment of anorexia in these pts than low doses (320 mg/day) of MA. Here we present the results of the quality of life sub-study which purpose is to evaluate the effect of reversing anorexia in pts health related quality of life (HRQOL). Methods: From February 1999 to April 2003, 160 non-mestastatic lung cancer pts who developed anorexia during radiotherapy were randomized to receive either 320 mg/day or 600 mg/day of MA. All pts who developed anorexia filled up the EuroQuol (EQ-5D) quality of life questionnaire before treated with MA and the responders did it again when appetite was regained. The endpoint was improvement in pts HRQOL (defined as an increase > 5 mm in the EQVAS score between the second and first questionnaires). Results: The analysis of the EuroQuol (EQ-5D) questionnaires of the 131 pts who responded to treatment with MA shows that 106 pts (81%) had an improvement > 5 mm in the EQVAS score while 19 % did not. The difference is statistically significant (Binomial test: p < 0.0001). Regarding differences between the two series, 42 pts improved in the 320 mg arm versus 64 in the 600 mg arm which is not statistically significant (Fisher test: p = 0.501). Conclusions: Our results indicate that reversal of anorexia with MA has a clinically significant improvement in HRQOL in non-metastatic lung cancer pts undergoing radiation therapy. The absence of statistically significant differences between the two series may be due to the sample size. [Table: see text] No significant financial relationships to disclose.

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