scholarly journals Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children

2019 ◽  
Vol 3 (1) ◽  
pp. 42
Author(s):  
I Gusti Ngurah Made Suwarba ◽  
Ni Putu Yunik Novayanti ◽  
I Gusti Lanang Sidiartha ◽  
Dewi Sutriani Mahalini
Keyword(s):  
Valproic Acid ◽  
Serum Level ◽  
Negative Correlation ◽  
Vitamin B6 ◽  
Active Form ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Acid Therapy ◽  
Valproic Acid Therapy ◽  
Weak Negative Correlation

Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand. Valproic acid increase the synthesis of serum GABAergic in the other hand vitamin B6 is required as cofactor for gamma-amino butyric acid (GABA) formation. The dosage and duration of valproic acid therapy might be correlated with vitamin B6 serum level. The aim of this study is to know the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy in children with epilepsy.Materials and Methods: This is a cross sectional study to investigate the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy. The level of vitamin B6 serum was determined by checking vitamin B6 active form in serum, pyridoxal 5’-phospate (PLP).Results: In this study, 37 epilepsy children with valproic acid duration therapy more than 3 months was enrolled. Fifty six percent epilepsy children were male, commonly on children age 1-5 years old. Spearman correlation coefficient test showed a significant weak negative correlation between vitamin B6 serum level and dosage of valproic acid (r=–0.35; p=0.03), and very weak negative correlation with valproic acid duration therapy (r=-0.08; p=0.59), however it was not significant. Conclusion: There was a significant weak negative correlation between vitamin B6 serum level and very weak negative correlation with valproic acid duration therapy, but not significant in children with epilepsy.Keywords: correlation, valproic acid, vitamin B6

scholarly journals Evaluation of the disability assessment Longshi scale: A multicenter study

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093429
Author(s):  
Yao Wang ◽  
Shanshan Li ◽  
Weiyi Pan ◽  
Peng Xiao ◽  
Jiehong Zhang ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Cross Sectional Study ◽  
Strong Positive Correlation ◽  
Disability Assessment ◽  
Social Activities ◽  
Cross Sectional ◽  
Test Analysis ◽  
Factors Affecting ◽  
Explanatory Variables ◽  
Weak Negative Correlation

Objective We investigated factors affecting the disability assessment Longshi scale, and differences between the Longshi and Barthel scales, as well as modified Rankin scale (mRS), to determine whether the Longshi scale is superior to the other scales. Methods This cross-sectional study included 721 participants with disability. We performed the t-test, analysis of variance, Pearson’s correlation test, and multiple linear regression to analyze group differences and define explanatory variables. Results The Longshi scale had a strong positive correlation with the Barthel scale (r = 0.868) but a weak negative correlation with the mRS (r = –0.185). Scores obtained among seven study hospitals in two provinces of southeast China were significantly different (F = 8.034). Social activities of participants with disability can be positively predicted using the Longshi (β = 0.251) and Barthel scales (β = 0.276). However, age has a weak negative correlation with the Longshi scale (r = –0.163). Conclusion Training did not cause significant variations in assessment using the Longshi scale. However, the results differed among different regions. The Longshi scale showed a strong correlation with the Barthel scale but a weak correlation with the mRS. Assessment time was shorter using the Longshi scale and the scale can be used to predict the social activities of individuals with disability.

scholarly journals Korelasi Aspek Spiritual dengan Kadar Interleukin-6 Serum pada Pasien Hemodialisis Kronik

2017 ◽  
Vol 3 (1) ◽  
pp. 3
Author(s):  
Wika Hanida ◽  
E Mudjaddid ◽  
Habibah Hanum Nasution ◽  
Hamzah Shatri
Keyword(s):  
Negative Correlation ◽  
Interleukin 6 ◽  
Holistic Approach ◽  
Cross Sectional Study ◽  
Chronic Hemodialysis ◽  
Inflammatory Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Spiritual Support ◽  
Cross Sectional ◽  
Weak Negative Correlation

Pendahuluan. Pendekatan holistik di bidang psikosomatik menekankan bahwa faktor spiritualitas dan dukungan padasisi spiritualitas dapat meningkatkan pelayanan serta memperbaiki kondisi psikologis pada pasien. Selama prosedurhemodialisis, respon inflamasi akan meningkat, dibuktikan dengan peningkatan konsentrasi interleukin-6 (IL-6). Aspekspiritual diyakini dapat menurunkan respon inflamasi. Oleh karena itu penelitian ini dilakukan untuk menguji hubunganantara tingkat spiritual dangan kadar IL-6 pada pasien hemodialisis kronik .Metode. Penelitian ini merupakan studi cross sectional yang dilakukan pada 51 pasien hemodialisis kronik di unit hemodialisisRSUP. H. Adam Malik dan RSU. Dr. Pirngadi Medan mulai bulan Juli-Agustus 2014. Pemeriksaan kadar IL-6 serum diukurdengan metode quantitative enzyme-linked immunosorbent assay (ELISA) serta dilakukan pengambilan sampel darah.Sementara itu, pengukuran spiritual dilakukan dengan pengisian kuesioner FACIT Sp-12 pada pagi hari, yaitu 30 menitsebelum hemodialisis berlangsung.Hasil. Didapatkan rerata skor subskala meaning (makna) 10,67 (SB 2,66), peace (damai) 9,63 (SB 2,19) dan faith (iman) 11,47 (SB 2,91). Nilai median kadar IL-6 serum pada penelitian ini adalah sebesar 5,63 (1,48-28,88) pg/mL, sedangkan nilai median FACIT Sp-12 adalah 30,00 (18-48). Hasil uji korelasi antara tingkat spiritual dengan kadar IL-6 serum menunjukkan koefisien korelasi (r) sebesar -0,330 dengan nilai p= 0,018, secara statistik menunjukkan korelasi negatif yang lemah.Simpulan. Spiritual pada pasien hemodialisis kronik tergolong tinggi serta terdapat korelasi negatif yang lemah antaraaspek spiritual dengan kadar IL-6 pada pasien hemodialisis kronik.Kata kunci: FACIT Sp-12, hemodialisis kronik, IL-6 Correlation between Spiritual Aspect and Serum Interleukin-6 Level in Chronic Hemodialysis PatientsIntroduction. Holistic approach in psychosomatic focus on spirituality factor and spiritual support is expected to improve services and psychological condition of the patients. Inflammatory response during hemodialisis procedure hence increased with the evidence of increasing level of serum interleukin-6 (IL-6). Further research is still needed to see the spiritual factors that can decrease the inflammatory factors. Methods. Cross sectional study on 51 chronic hemodialisis patients at RSUP. H. Adam Malik and RSU dr. Pirngadi Medan between July-August 2014. Serum IL-6 was measured using quantitative enzyme-linked immune sorbent assay (ELISA) methods. Blood samples and spiritual aspect assessment by handing out FACIT Sp-12 questionnaire to patients were taken in the morning, 30 minutes before hemodialisis. Results. Subscale meaning 10.67 (SB 2.66), peace 9.63 (SB 2.19) and faith 11.47 (SB 2.91). Median serum IL-6 level is 5,63 (1,48- 28,88) pg/mL. Median FACIT Sp-12 is 30,00 (18-48). Correlation test between serum IL-6 level and spiritual aspect have shown statistically weak negative correlation (correlation coefficient -0,330, p=0.018). Conclusions: spirituality level in chronic hemodialisis patients are higher. Weak negative correlation between serum IL-6 level and spiritual level on chronic hemodialisis patients was found in this study. Keywords: Chronic hemodialisis, FACIT Sp-12, IL-6

scholarly journals Relationship between family functions with depression in palliative patients

2021 ◽  
Vol 2 (1) ◽  
pp. 1-3
Author(s):  
Johan Kurniawan ◽  
Ni Ketut Putri Aryani ◽  
Ida Ayu Kusuma Wardani
Keyword(s):  
Negative Correlation ◽  
Cross Sectional Study ◽  
Health Condition ◽  
Cross Sectional ◽  
Family Function ◽  
Family Assessment Device ◽  
The Family ◽  
Function Correlation ◽  
Weak Negative Correlation ◽  
Palliative Patients

Background: Diseases or health problems are a part of life that can occur at any time. Terminal disease represents a patient's irreversible health condition, so that this group of patients can be given a therapeutic approach known as palliative care. Patients who experience significant conflict in the family can increase the likelihood of depression. Patients and Methods: This is a descriptive cross-sectional study in 32 subjects chosen by consecutive sampling. Measuring instrument used was Beck’s Depression Inventory. The family function scale is derived from the McCaster’s Model of Family Functioning known as the Family Assessment Device (FAD). Results: In this study, the average age of the sample was 46 years, unmarried from high school education. In the description of family functions obtained with overall results with moderate function. Correlation between the two things was found to be a weak negative correlation between FAD score and BDI score. The smaller the value score of FAD then will the greater the value of BDI. The worse the function of the family will be more severe levels of depression experienced by the sample in this study. Conclusion: We found there was a significant weak negative correlation between family function and depression in palliative patients at Sanglah Hospital Denpasar.

scholarly journals Impact of kinesiophobia on physical function and quality of life in functional ankle instability individuals: an observational study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Prachita P. Walankar ◽  
Vrushali P. Panhale ◽  
Kanchi M. Vyas
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Negative Correlation ◽  
Ankle Instability ◽  
Cross Sectional Study ◽  
Functional Ankle Instability ◽  
Cross Sectional ◽  
Sf 36 ◽  
Related Quality

Abstract Background Functional ankle instability is a common musculoskeletal condition affecting the community. It is characterized by repetitive bouts of giving away, recurrent sprains, and sensation of instability leading to functional deficits in an individual. The present study aimed to assess the influence of kinesiophobia on physical function and quality of life in participants with functional ankle instability. A cross-sectional study was conducted in 30 participants with functional ankle instability. Kinesiophobia was assessed using the 17-item Tampa Scale of Kinesiophobia, physical function using the Foot and Ankle Ability Measure (FAAM) and the FAAM-Sport version (FAAM-S), and quality of life using SF-36. Results The TSK score showed a moderate negative correlation with FAAM-S (r = −0.5, p = 0.005) and a weak negative correlation with SF-36 physical component summary (r = −0.42, p = 0.02). However, TSK showed no significant correlation with FAAM-ADL and SF-36 mental component summary. Conclusion Increased fear of movement, reduced physical function, and health-related quality of life were observed in functional ankle instability individuals. Hence, evaluation of these parameters is imperative in these individuals.

Association of genetic variants in six candidate genes with valproic acid therapy optimization

2011 ◽  
Vol 12 (8) ◽  
pp. 1107-1117 ◽  
Author(s):  
Chin-Chuan Hung ◽  
Jia-Ling Ho ◽  
Wei-Lun Chang ◽  
John Jen Tai ◽  
Tsung-Jen Hsieh ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Candidate Genes ◽  
Genetic Variants ◽  
Acid Therapy ◽  
Valproic Acid Therapy

Đánh giá nồng độ lactate và procalcitonin ở bệnh nhân Covid-19

2022 ◽  
Author(s):  
Thanh Xuan Nguyen
Keyword(s):  
Serum Level ◽  
Respiratory Infections ◽  
Severe Pneumonia ◽  
Cross Sectional Study ◽  
Multiple Organ ◽  
High Rate ◽  
Rt Pcr ◽  
Wuhan City ◽  
Cross Sectional ◽  
The Relationship

TÓM TẮT Đặt vấn đề: Bệnh COVID-19 đa dạng từ không có triệu chứng đến có các triệu chứng nhẹ cho đến viêm phổi nặng, hội chứng suy hô hấp cấp tiến triển (ARDS), nhiễm khuẩn huyết suy đa tạng và tử vong. Người cao tuổi, người có bệnh mạn tính sẽ có nguy cơ diễn biến nặng nhiều hơn. Nghiên cứu này nhằm xác định nồng độ lactate và PCT ở những bệnh nhân Covid-19 và xét mối liên quan giữa lactate và PCT trên bệnh nhân Covid-19. Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang trên 126 bệnh nhân được chẩn đoán nhiễm Sars-Cov-2 bằng xét nghiệm RT PCR. Kết quả: Tuổi trung bình 55,98 ± 17,1 tuổi (4 - 98 tuổi). Bệnh nhân > 60 tuổi chiếm tỉ lệ cao nhất (42,8%). Trung vị PCT: 3,6 (95%CI:3,21 - 3,75) ng/ml; trung vị lactate 1,5 (95%CI:1,21 - 1,91) mmol/L; lactate có tương quan thuận và yếu với procalcitonin với r = 0,241; p < 0,001. Nồng độ procalcitonin > 0,1 ng/ml; lactate > 2 mmol/l ở bệnh nhân Covid-19 chiếm tỷ lệ cao với 89,7% và 39,7%. Kết luận: Chỉ điểm procalcitonin, lactate tăng cao ở bệnh nhân Covid-19. ABSTRACT ASSESSMENT OF SERUM LEVEL OF LACTATE AND PROCALCITONIN IN COVID-19 PATIENTS Background: Sars-CoV-2 has been identified as the cause of acute respiratory infections in Wuhan city, Hubei province, China, and has since spread worldwide. Sars-CoV-2 is capable of aerosol transmission in enclosed, crowded, and poorly ventilated spaces. COVID-19 illness ranges from asymptomatic to mild symptoms to severe pneumonia, acute respiratory distress syndrome (ARDS), sepsis, multiple organ failure, and death. This study aims to determine lactate and PCT levels in Covid-19 patients and examine the relationship between lactate and PCT in Covid-19 patients. Methods: A cross-sectional study was performed on 126 patients diagnosed with Sars-Cov-2 infection by RT-PCR. Results: Mean age was 55.98 ± 17.1 years (range: 4-98 years). Patients more than 60 years old were accounted for the highest rate (42.8%). Median PCT: 3.6 (95%CI:3.21 - 3.75) ng/ml; median lactate 1.5 (95%CI:1.21 - 1,91) mmol/L; lactate has a positive and weak correlation with procalcitonin with r = 0.241; p < 0.001. Procalcitonin concentration > 0.1 ng/ml; lactate > 2 mmol/l in patients with Covid-19 accounted for a high rate with 89.7% and 39.7%. Conclusion: Serum level of procalcitonin and lactate raise highly in Covid-19 patients. Keywords: Covid-19, procalcitonin, lactate.

Effect of Valproic Acid Therapy on Zinc Metabolism in Children with Primary Epilepsy

1987 ◽  
Vol 10 (1) ◽  
pp. 80-86 ◽  
Author(s):  
T. Lerman-Sagie ◽  
M. Statter ◽  
G. Szabo ◽  
P. Lerman
Keyword(s):  
Valproic Acid ◽  
Zinc Metabolism ◽  
Acid Therapy ◽  
Valproic Acid Therapy

scholarly journals Nurses Burnout, Resilience, and Its Association With Socio-Demographic Factors During COVID-19 Pandemic

2022 ◽  
Vol 12 ◽  
Author(s):  
Majid Heidari Jamebozorgi ◽  
Ali Karamoozian ◽  
Tayebe Ilaghinezhad Bardsiri ◽  
Hojjat Sheikhbardsiri
Keyword(s):  
Negative Correlation ◽  
Maslach Burnout Inventory ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Stressful Events ◽  
Personal Accomplishment ◽  
Cross Sectional ◽  
Work Related ◽  
Socio Demographic Factors

BackgroundIn the recent pandemic, nurses have faced workload and being exposed to burnout. Resilience helps address work-related psychological problems such as stressful events and burnout. According to the roles of nurses in the healthcare system, we investigated the relationship between resiliency and burnout in nurses.Material and MethodsIn this descriptive analytical cross-sectional study, 364 nurses participated from April to June 2021. Census sampling was used to recruit participants. Maslach burnout inventory (MBI), Connor-Davidson Resiliency Scale (CDRISC), and a demographic check-list were utilized to collect data. Data analysis was done using SPSS version 22. Shapiro-Wilk, Kruskal–Wallis test, Mann–Whitney U-test, correlation analysis, and generalized linear model were applied accordingly.ResultsOverall, the findings showed that nurses had severe symptoms of burnout and a moderate level of resilience. The two domains of burnout, emotional exhaustion and personal accomplishment had a significantly negative correlation with resilience (r = −0.442, p &lt; 0.001 and r = −0.351, p = 0.03, respectively). Linear regression showed that demographic characteristics (Hospital type, ward type, gender, and overtime) were the major predictors of the 3 sub-categories of burnout. A significant negative correlation was observed between burnout and resilience highlighting the role of resilience in reducing burnout (P &lt; 0.05).ConclusionIn order to help nurses to tackle and endure burnout in pandemic times, there is a need to implement national and local policies to help them accordingly.

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