scholarly journals A new ferrous iron-uptake transporter, EfeU (YcdN), from Escherichia coli

2006 ◽  
Vol 62 (1) ◽  
pp. 120-131 ◽  
Author(s):  
Cornelia Große ◽  
Judith Scherer ◽  
Doreen Koch ◽  
Markus Otto ◽  
Nadine Taudte ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Ferrous Iron ◽  
Iron Uptake

scholarly journals Do FeS clusters rule bacterial iron regulation?

2020 ◽  
Vol 295 (46) ◽  
pp. 15464-15465
Author(s):  
Roland Lill
Keyword(s):  
Escherichia Coli ◽  
Ferrous Iron ◽  
Iron Uptake ◽  
Iron Regulation ◽  
Ferric Uptake Regulator ◽  
Iron Binding ◽  
Cellular Iron ◽  
Open Question ◽  
Exciting Possibility

For decades, the bacterial ferric uptake regulator (Fur) has been thought to respond to ferrous iron to transcriptionally regulate genes required for balancing iron uptake, storage, and utilization. Because iron binding to Fur has never been confirmed in vivo, the physiological iron-sensing mechanism remains an open question. Fontenot et al. now show that Fur purified from Escherichia coli binds an all-Cys-coordinated [2Fe-2S] cluster. This finding opens the exciting possibility that Fur may join numerous well-studied bacterial, fungal, and mammalian proteins that use FeS clusters for cellular iron regulation.

FeoB is not required for ferrous iron uptake inCampylobacter jejuni

2003 ◽  
Vol 49 (11) ◽  
pp. 727-731 ◽  
Author(s):  
Brian H Raphael ◽  
Lynn A Joens
Keyword(s):  
Escherichia Coli ◽  
Helicobacter Pylori ◽  
Campylobacter Jejuni ◽  
Ferrous Iron ◽  
Iron Uptake ◽  
No Reduction ◽  
Amino Acid Identity ◽  
Acid Identity ◽  
E Coli ◽  
Magnesium Transporter

Among strains of Campylobacter jejuni, levels of ferrous iron (Fe2+) uptake was comparable. However, C. jejuni showed a lower level of ferrous iron uptake than Escherichia coli. Consistent with studies of E. coli, Fe2+uptake in C. jejuni was significantly enhanced by low Mg2+concentration. The C. jejuni genome sequence contains a single known ferrous iron uptake gene, feoB, whose product shares 50% amino acid identity to Helicobacter pylori FeoB and 29% identity to E. coli FeoB. However, Fe2+uptake could not be attributed to FeoB for several reasons. Site-directed mutations in feoB caused no defect in55Fe2+uptake. Among C. jejuni strains, various nucleotide alterations were found in feoB, indicating that some C. jejuni feoB genes are defective. In addition, uptake could not be attributed to the magnesium transporter CorA, since no reduction in55Fe2+uptake was observed in the presence of a CorA-specific inhibitor.Key words: Campylobacter jejuni, ferrous iron uptake, metal transport, FeoB.

Ferrous iron uptake by Bifidobacterium bifidum var. Pennsylvanicus: The effect of metals and metabolic inhibitors

1987 ◽  
Vol 19 (6) ◽  
pp. 517-522 ◽  
Author(s):  
Anatoly Bezkorovainy ◽  
Leslie Solberg ◽  
Mark Poch ◽  
Robin Miller-Catchpole
Keyword(s):  
Ferrous Iron ◽  
Iron Uptake ◽  
Bifidobacterium Bifidum ◽  
Metabolic Inhibitors

scholarly journals Toward a mechanistic understanding of Feo-mediated ferrous iron uptake

Metallomics ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 887-898 ◽  
Author(s):  
Alexandrea E. Sestok ◽  
Richard O. Linkous ◽  
Aaron T. Smith
Keyword(s):  
Ferrous Iron ◽  
Iron Uptake ◽  
Iron Transport ◽  
Structure And Function ◽  
Ferrous Iron Transport ◽  
Mechanistic Understanding ◽  
And Function

The ferrous iron transport (Feo) system is the predominant mode of bacterial Fe2+import. Advancements in the structure and function of FeoB provide glimpses into the mechanism of Fe2+uptake.

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