Psoriasis, Sacro-Iliitis and Peripheral Arthritis Occurring in Patients with the same HLA Haplotype. A Preliminary Family Report a Hypothetical Explanation of the Interaction between MHS Products

Background: Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease leading to functional limitations and subsequently impaired quality of life (QoL). Despite the fact that QoL was recognized as a significant perception, it was excluded from the core domains (defined by the Assessment of Spondyloarthritis International Society), because of ambiguity of measurement choice. Aim: To assess QoL in patients with AS using a generic; Short Form-36 (SF-36) and a diseasespecific; Ankylosing Spondylitis quality of life (ASQoL) instruments and to explore its relationship to the clinical characteristics, disease activity, functional status, and radiographic severity. Methods: A total of 47 AS patients who fulfilled modified New York criteria were included. Disease activity, functional status, spinal mobility, and radiographic severity were assessed by Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), Bath AS Metrology Index (BASMI) and Bath AS Radiology Index (BASRI) respectively. SF-36 and ASQoL instruments evaluated Qol. Results: Physical health was more affected especially in patients with peripheral arthritis by SF-36 (p=0.008) and ASQoL (p=0.022) scores. Both SF-36 total and ASQoL scores correlated significantly with BASDAI (r = -0.329, p = 0.024 and r = 0.420, p = 0.003), BASFI (r = -0.399, p = 0.005 and r = 0.513, p=0.001) and BASMI (r = -0.382, p = 0.008 and r = 0.482, p= 0.001) respectively. Conclusion: QoL was impaired in AS patients with highest impact on physical health especially in association with peripheral arthritis. SF-36 and ASQol have a comparable achievement in the evaluation of QoL in AS patients and both physical function and spinal mobility were identified as predictors of poor QoL.

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How can electric lighting contribute to human health and well-being?

Lighting Research and Technology ◽

10.1177/14771535211003264 ◽

2021 ◽

Vol 53 (5) ◽

pp. 515-522

Author(s):

P Raynham

Keyword(s):

Human Health ◽

Psychological Impact ◽

Health Benefits ◽

Well Being ◽

Health Problems ◽

Starting Point ◽

Electric Light ◽

Health And Well Being ◽

Hypothetical Explanation

Electric light in buildings may provide some health benefits; however, for most people these benefits are likely to be small. It is possible for electric lighting to cause health problems, if there is too little light or there is glare, but for the most part there is good guidance available and these problems can be avoided. The quality of the lit environment can have a psychological impact and this may in turn impact well-being. A starting point for this is perceived adequacy of illumination. Related lighting metrics are examined and a hypothetical explanation is suggested.

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AB0635 HOW ARE NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID) PRESCRIBED IN AXIAL SPONDYLOARTHRITIS?

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.6221 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1613.1-1613

Author(s):

K. Ben Abdelghani ◽

Y. Gzam ◽

A. Fazaa ◽

S. Miladi ◽

K. Ouenniche ◽

...

Keyword(s):

Axial Spondyloarthritis ◽

Maximum Dose ◽

Tnf Alpha ◽

First Line ◽

Peripheral Arthritis ◽

Biological Treatments ◽

Synthetic Dmards ◽

Nsaid Prescription ◽

Axial Form ◽

Inflammatory Drugs

Background:For decades, NSAID have been used as the first-line drugs to treat axial spondyloarthritis (ax-SpA). However, the NSAID prescription strategy is not clearly detailed and it varies from one clinician to another.Objectives:The aim of this study was to assess the NSAID prescription modalities adopted in ax-SpA and the differences between these modalities.Methods:This is a descriptive study including 200 cases of ax-SpA fulfilling the ASAS 2009 criteria and diagnosed between January 2000 and October 2019. The demographic and clinical features of the ax-SpA were collected and the modalities of prescription of NSAID were retrospectively assessed.Results:Our population consists of 138 men and 62 women with a mean age of 43,3 ± 11,2 years. The HLA B-27 antigen was present in 50,8% of cases. The ax-SpA was a pure axial form in 67% of patients, associated with peripheral arthritis, enthesitis and dactylitis in 19%, 21,5% and 1,5% respectively.One hundred eighty patients (90%) had been treated with NSAIDs. The NSAIDs used were: the Diclofenac (57.5%), Indomethacin (37.5%), Piroxicam (36%), clecoxib (34%), Naproxen (29.5%) and ketoprofen (13%). Seventy-three patients (36.5%) had used at least 3 NSAIDs.Among the 180 patients treated with NSAID, 88 patients (48,8%) were treated with conventional synthetic DMARDs (csDMARDs) in association with NSAID: Salazopyrine (43,3%) and Methotrexate (13,3%). Seventy-one patients (39,4%) had necessitated the use of anti-TNF alpha.NSAIDs were used continuously in 115 patients (63.8%) and the maximum dose of NSAIDs was used in 78 patients (43.3%). By comparing patients who used maximum doses of NSAIDs and those who used NSAID continuously with other patients, we noticed that the use of biological treatments was more frequent in those groups (p = 0,01 and p=0,004 respectively).In addition, while comparing the group of patients co-treated with csDMARDs with other patients treated with NSAID on monotherapy, we noted that this group of patients had more arthritis (p<0,0001), enthesitis (p=0,02), psoriasis (p=0,04) and necessitated more biological treatments (p=0,01).Conclusion:Our results suggest that maximal doses and/or continuous prescription of NSAID were mainly used if there was no response to that treatment. The csDMARDs were more prescribed if there were peripheral manifestations or psoriatic arthritis and those forms were also more candidates to biological treatments.References:[1]Wang R, et al. Arthritis Rheumatol Hoboken NJ. 2019;Disclosure of Interests:None declared

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Characterization and prevalence of spondyloarthritis and peripheral arthritis among patients with inflammatory bowel disease

Clinical and Experimental Gastroenterology ◽

10.2147/ceg.s136383 ◽

2017 ◽

Vol Volume 10 ◽

pp. 259-263 ◽

Cited By ~ 11

Author(s):

Hoda Malaty ◽

Grace Lo ◽

Jason Hou

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Peripheral Arthritis ◽

Inflammatory Bowel

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The prevalence and incidence of peripheral arthritis in patients with inflammatory bowel disease, a prospective population-based study (the IBSEN study)

Rheumatology ◽

10.1093/rheumatology/40.11.1256 ◽

2001 ◽

Vol 40 (11) ◽

pp. 1256-1261 ◽

Cited By ~ 68

Author(s):

O. Palm

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Population Based ◽

Peripheral Arthritis ◽

Population Based Study ◽

Inflammatory Bowel

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Carboxylesterase overexpression in the male reproductive tract: a universal safeguarding mechanism?

Reproduction Fertility and Development ◽

10.1071/rd99011 ◽

1999 ◽

Vol 11 (3) ◽

pp. 133 ◽

Cited By ~ 16

Author(s):

A. T. Mikhailov ◽

M. Torrado

Keyword(s):

Reproductive Tract ◽

Expression Patterns ◽

Cell Lineage ◽

Environmental Chemicals ◽

Male Reproductive Tract ◽

Morphological Organization ◽

Associated Functions ◽

And Function ◽

Hypothetical Explanation

Data on expression patterns of carboxylesterases in the male reproductive tract of different animal groups (i.e. bivalve mollusks, fruitflies and rodents) are summarized to highlight some particularly interesting questions in the context of sperm differentiation, maturation and function. The male reproduc-tive system, in spite of extreme variation in the anatomical/morphological organization in different species, is characterized by similar patterns of male-dependent carboxylesterase overexpression. The phenomenon of conserved carboxylesterase overexpression indicates similar male sex-associated functions of the enzymes. There is possible evidence of carboxylesterase recruitment by male reproductive-tract tissues indi-cating that it could be adaptive for spermatogenesis, sperm maturation and sperm use. Moreover, this idea can be extended to include a sperm cell lineage protection. This issue is discussed in the light of recent data on environmental reproductive xenobiotics that can provide a basis for a hypothetical explanation of car-boxylesterase overexpression in the male reproductive tract. Based on a well-known role of car-boxylesterases in detoxification of environmental chemicals such as organophosphate pesticides, it is proposed that various male genital tract carboxylesterases may be characterized by a similar physiological function to protect the male reproductive system against xenobiotic influences that could provoke its dys-function, thus altering sperm differentiation and maturation.

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Peripheral Arthritis

Musculoskeletal Diseases ◽

10.1007/88-470-0339-3_21 ◽

2005 ◽

pp. 143-147

Author(s):

L.F. Rogers ◽

C.S. Resnik

Keyword(s):

Peripheral Arthritis

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Evidence for Two Regions in the Mouse t Complex Controlling Transmission Ratios

Genetics Research ◽

10.1017/s0016672300020632 ◽

1981 ◽

Vol 38 (3) ◽

pp. 315-325 ◽

Cited By ~ 30

Author(s):

Józefa Styrna ◽

Jan Klein

Keyword(s):

Lethal Factor ◽

Compound Heterozygote ◽

The Other ◽

Transmission Ratio ◽

Crossing Over ◽

Normal Length ◽

T Complex ◽

Segregation Distorter ◽

Haplotype A ◽

Made In

SUMMARYFour new t haplotypes, tTu1 through tTu4, are described, three of them derived from the tw12tf haplotype and one (tTu4) from the tw2 haplotype. The tTu1 and tTu4 haplotypes cause taillessness in T/tTu1 or T/tTu4 heterozygotes, lack the lethality factor, weakly suppress recombination in the T−H−2 interval, and are transmitted to offspring from tTu/ + males at nearly Mendelian ratios. The tTu3 haplotype resembles tTu1 and tTu4 except for the fact that the T/tTu3 heterozygotes have normal-length tails. The tTu2 haplotype probably carries the lethal factor of tTu12tf, suppresses crossing-over in the T-H-2 and tf-H-2 intervals, and displays a slightly subnormal transmission ratio. In the compound heterozygote tTu1/tTu2, the male transmission ratio of the tTu1 chromosome is close to that of the original tTu12tf haplotype. A similar effect is observed in the tTu3/tTu2 heterozygote. This observation is interpreted as evidence for two regions within the t complex controlling the male transmission ratios. One of the regions is close to the tail-modifying region, the other is close to the lethality factor. Our findings parallel closely those made in the segregation distorter system in Drosophila.

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