Lung function at 10 yr is not impaired by early childhood lower respiratory tract infections

2009 ◽  
Vol 20 (3) ◽  
pp. 254-260 ◽  
Author(s):  
Geir Håland ◽  
Karin Cecilie Lødrup Carlsen ◽  
Petter Mowinckel ◽  
Monica Cheng Munthe-Kaas ◽  
Chandra Sekhar Devulapalli ◽  
...  
Author(s):  
Franca Rusconi ◽  
Enrico Lombardi ◽  
Elena Spada ◽  
Sonia Brescianini ◽  
Martina Culasso ◽  
...  

Objective: To evaluate the relationship between lower respiratory tract infections (LRTI), in the first 2 years of life and lung function at school age in the Piccolipiù birth cohort (Italy). Methods: Data on LRTI (doctor diagnosis of bronchitis, bronchiolitis, pneumonia) and wheezing (≥3 episodes or a diagnosis of asthmatic bronchitis) in the first 2 years of life were obtained from parental questionnaires. Lung function was assessed at 7 years by spirometry and forced volume vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, forced expiratory flow between 25 and 75%, and at 75% of FVC (FEF25-75 and FEF75) were reported as z-scores. The associations between LRTI and spirometric variables were estimated with linear regression models. Results: Among 877 children studied, 22.1% had LRTI only, 5.4% wheezing only, 13.2% had both, and 59.3% had neither LRTI nor wheezing. Children with LRTI had lower FVC and FEV1 than children without (z-score differences: -0.18 (95% Confidence Intervals, -0.31; -0.06) and -0.15 ( 0.27; -0.03)). When children were stratified by history of both LRTI and wheezing, there was no association between LRTI only and spirometric values. Conversely, having had both LRTI and wheezing was inversely associated with all lung function measures: z-score differences of -0.24 ( 0.42; -0.07); -0.42 (-0.59; -0.24); -0.25 (-0.41; -0.08); -0.37 (-0.54; -0.21); -0.30 (-0.46; -0.14) for FVC, FEV1, FEV1/FVC, FEF25-75 and FEF75, respectively. Conclusion: Infants with wheezing and LRTI, but not those with LRTI only, had reduced lung function at school-age.


2021 ◽  
pp. 1-16
Author(s):  
Mark S. Brittan ◽  
Angela Moss ◽  
John D. Watson ◽  
Monica J. Federico ◽  
John D. Rice ◽  
...  

Thorax ◽  
2011 ◽  
Vol 66 (6) ◽  
pp. 468-473 ◽  
Author(s):  
S. B. Drysdale ◽  
T. Wilson ◽  
M. Alcazar ◽  
S. Broughton ◽  
M. Zuckerman ◽  
...  

2020 ◽  
Vol 56 (1) ◽  
pp. 1901829
Author(s):  
Evelien R. van Meel ◽  
Marina Attanasi ◽  
Vincent W.V. Jaddoe ◽  
Irwin K.M. Reiss ◽  
Henriëtte A. Moll ◽  
...  

IntroductionChlamydia trachomatis is the most commonly reported sexually transmitted disease and although infection during pregnancy is associated with neonatal complications, long-term respiratory consequences are unknown. We aimed to determine whether C. trachomatis infection during pregnancy is associated with asthma-related symptoms across childhoodMethodsThis study among 2475 children and their mothers was embedded in a population-based prospective cohort study. Maternal urine samples were tested for C. trachomatis infection during pregnancy. Questionnaires provided information on childhood physician-attended lower respiratory tract infections and wheezing, and current asthma at age 10 years. Lung function was measured by spirometry at age 10 years.ResultsThe prevalence of C. trachomatis infection during pregnancy was 3.2% (78 out of 2475). C. trachomatis infection during pregnancy was not associated with lower respiratory tract infections until age 6 years, but was associated with a higher odds of wheezing in children until age 10 years (OR 1.50 (95% CI 1.10–2.03)). C. trachomatis infection during pregnancy was associated with an increased odds of asthma (OR 2.29 (95% CI 1.02–5.13)), and with a lower forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow at 75% of forced vital capacity (z-score difference −0.28 (95% CI −0.52– −0.04) and −0.24 (95% CI −0.46– −0.01), respectively) in children at age 10 years. The observed associations were only partly explained by mode of delivery, gestational age at birth or birthweight.ConclusionsC. trachomatis infection during pregnancy is associated with increased odds of wheezing, asthma and impaired lung function. The causality of the observed associations and potential underlying mechanisms need to be explored.


2007 ◽  
Vol 26 (11) ◽  
pp. 1019-1024 ◽  
Author(s):  
Simon Broughton ◽  
Karl P. Sylvester ◽  
Grenville Fox ◽  
Mark Zuckerman ◽  
Melvyn Smith ◽  
...  

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