Total Body and Splanchnic Thermogenesis in Curarized Man During a Short Exposure to Cold

1980 ◽  
Vol 24 (4) ◽  
pp. 339-344 ◽  
Author(s):  
K. Jessen ◽  
A. Rabøl ◽  
K. Winkler
1963 ◽  
Vol 41 (1) ◽  
pp. 2225-2235
Author(s):  
A. DesMarais ◽  
P. A. Lachance

The well known reduction in growth rate of cold-acclimated rats has been shown to depend on a decreased gain in total body fat, without change in the gain in lean body weight. This has been observed in rats fed Lab Chow or a high-fat diet ad libitum. In those groups fed a high-carbohydrate diet ad libitum or calorie-restricted high-fat or high-carbohydrate diets, exposure to cold had no effect on the gain in neither total body weight nor lean body weight, which were already reduced by the diet; in those animals, the significant decrease in the gain in total body fat upon exposure to cold was compensated by a slight but unsignificant increase in the gain in lean body weight, so that differences in gain in total body weight were not significant.


1964 ◽  
Vol 207 (4) ◽  
pp. 865-867 ◽  
Author(s):  
Chandicharan Deb ◽  
Mohan Chand Boral

Body fluid and hematological values were compared in the toad ( Bufo melanostictus), a poikilothermic animal, kept at 6 C for 48 hr, and in the same animal at 32 C. Exposure to cold caused a reduction in total body water but an increase in plasma volume. There was no significant difference in blood volume and thiocyanate space between the two groups. The red blood cell count in the control animals of this amphibian class was found to be markedly low compared to mammals, and a further reduction occurred on exposure to cold. No notable alteration could be observed in the hemoglobin levels and hematocrit values due to either difference in class of vertebrates or to temperature exposure.


1957 ◽  
Vol 35 (1) ◽  
pp. 631-636 ◽  
Author(s):  
D. G. Baker ◽  
E. A. Sellers

Some aspects of electrolyte metabolism in the rat exposed to a low environmental temperature have been examined. The first day of exposure at 2 °C. was accompanied by a loss of chloride. Continued exposure to cold resulted in a retention of sodium, and to a lesser extent, of potassium. Exposure to cold for 45 days (at 2 °C.) caused a sustained elevation of concentration of sodium in the plasma, with a transient increase in potassium and no change in the chloride concentration. Prolonged exposure to cold resulted in an increased blood volume and total body water content. These observations suggest that the rats acclimatized to cold have a larger proportion of actively metabolizing tissues than do comparable animals at room temperature.


1963 ◽  
Vol 41 (11) ◽  
pp. 2225-2235
Author(s):  
A. DesMarais ◽  
P. A. Lachance

The well known reduction in growth rate of cold-acclimated rats has been shown to depend on a decreased gain in total body fat, without change in the gain in lean body weight. This has been observed in rats fed Lab Chow or a high-fat diet ad libitum. In those groups fed a high-carbohydrate diet ad libitum or calorie-restricted high-fat or high-carbohydrate diets, exposure to cold had no effect on the gain in neither total body weight nor lean body weight, which were already reduced by the diet; in those animals, the significant decrease in the gain in total body fat upon exposure to cold was compensated by a slight but unsignificant increase in the gain in lean body weight, so that differences in gain in total body weight were not significant.


1957 ◽  
Vol 35 (8) ◽  
pp. 631-636 ◽  
Author(s):  
D. G. Baker ◽  
E. A. Sellers

Some aspects of electrolyte metabolism in the rat exposed to a low environmental temperature have been examined. The first day of exposure at 2 °C. was accompanied by a loss of chloride. Continued exposure to cold resulted in a retention of sodium, and to a lesser extent, of potassium. Exposure to cold for 45 days (at 2 °C.) caused a sustained elevation of concentration of sodium in the plasma, with a transient increase in potassium and no change in the chloride concentration. Prolonged exposure to cold resulted in an increased blood volume and total body water content. These observations suggest that the rats acclimatized to cold have a larger proportion of actively metabolizing tissues than do comparable animals at room temperature.


Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.


Author(s):  
Vivian V. Yang ◽  
S. Phyllis Stearner

The heart is generally considered a radioresistant organ, and has received relatively little study after total-body irradiation with doses below the acutely lethal range. Some late damage in the irradiated heart has been described at the light microscopic level. However, since the dimensions of many important structures of the blood vessel wall are submicroscopic, investigators have turned to the electron microscope for adequate visualization of histopathological changes. Our studies are designed to evaluate ultrastructural changes in the mouse heart, particularly in the capillaries and muscle fibers, for 18 months after total-body exposure, and to compare the effects of 240 rad fission neutrons and 788 rad 60Co γ-rays.Three animals from each irradiated group and three control mice were sacrificed by ether inhalation at 4 days, and at 1, 3, 6, 12, and 18 months after irradiation. The thorax was opened and the heart was fixed briefly in situwith Karnofsky's fixative.


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