scholarly journals It?s time for an aetiology-based definition of chronic obstructive pulmonary disease

Respirology ◽  
2007 ◽  
Vol 12 (3) ◽  
pp. 317-319 ◽  
Author(s):  
Marc Miravitlles ◽  
Josep Morera
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Definition Of

Chronic Obstructive Pulmonary Disease

2014 ◽  
pp. 334-345 ◽  
Author(s):  
John J. Reilly
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Health Care ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Airflow Obstruction ◽  
Health Care Practitioner ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Definition Of ◽  
The U.S

Virtually every health care practitioner who provides care to adults will encounter individuals with chronic obstructive pulmonary disease (COPD). Current estimates of the prevalence of the condition vary based on the method of ascertainment: most surveys show that approximately 6% of adults report a doctor's diagnosis of COPD but that approximately 25% have airflow obstruction when assessed by spirometry. COPD is common, morbid, mortal, and expensive: estimates are that 〉20 million U.S. adults have COPD and that it is responsible for 〉120,000 deaths annually with a cost to the U.S. economy of more than $38 billion. This chapter describes the definition of COPD, presenting clinical symptomatology and evaluation, natural history, differential diagnosis, current concepts of pathogenesis, therapeutic options, and the evaluation of a patient with known or suspected COPD considering surgery.

scholarly journals Paradigms in chronic obstructive pulmonary disease: phenotypes, immunobiology, and therapy with a focus on vascular disease

2017 ◽  
Vol 65 (6) ◽  
pp. 953-963 ◽  
Author(s):  
Michael Schivo ◽  
Timothy E Albertson ◽  
Angela Haczku ◽  
Nicholas J Kenyon ◽  
Amir A Zeki ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Early Stage ◽  
Vascular Inflammation ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Obstructive Pulmonary Disease ◽  
Disease Phenotypes ◽  
Definition Of

Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome that represents a major global health burden. COPD phenotypes have recently emerged based on large cohort studies addressing the need to better characterize the syndrome. Though comprehensive phenotyping is still at an early stage, factors such as ethnicity and radiographic, serum, and exhaled breath biomarkers have shown promise. COPD is also an immunological disease where innate and adaptive immune responses to the environment and tobacco smoke are altered. The frequent overlap between COPD and other systemic diseases, such as cardiovascular disease, has influenced COPD therapy, and treatments for both conditions may lead to improved patient outcomes. Here, we discuss current paradigms that center on improving the definition of COPD, understanding the immunological overlap between COPD and vascular inflammation, and the treatment of COPD—with a focus on comorbid cardiovascular disease.

scholarly journals Exogenic and endogenic factors in chronic obstructive pulmonary disease forming

2003 ◽  
Vol 2 (1) ◽  
pp. 75-77
Author(s):  
E. B. Bukreeva ◽  
S. A. Bogushevich ◽  
E. A. Dementieva ◽  
G. E. Chernogoryuk ◽  
S. V. Nesterovich ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Definition Of ◽  
Pi Deficiency ◽  
Tree Composition

To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.

scholarly journals Asthma Masquerading as Chronic Obstructive Pulmonary Disease: A Study of Smokers Fulfilling the GOLD Definition of Chronic Obstructive Pulmonary Disease

Respiration ◽  
2011 ◽  
Vol 82 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Feisal A. Al-Kassimi ◽  
Abdullah A. Abba ◽  
Mohammed S. Al-Hajjaj ◽  
Esam H. Alhamad ◽  
Emad Raddaoui ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Definition Of

Delayed Gastric Emptying Post-Esophagectomy: A Single-Institution Experience

2020 ◽  
Vol 15 (6) ◽  
pp. 547-554
Author(s):  
Allison B. Frederick ◽  
William R. Lorenz ◽  
Stella Self ◽  
Christine Schammel ◽  
William D. Bolton ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Gastric Emptying ◽  
Pulmonary Disease ◽  
Delayed Gastric Emptying ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Postoperative Course ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Definition Of

Objective Delayed gastric emptying (DGE) is a common functional disorder after esophagectomy in patients with esophageal carcinoma. Management of DGE varies widely and it is unclear how comorbidities influence the postoperative course. This study sought to determine factors that influence postoperative DGE. Methods This retrospective study evaluates patients who underwent esophagectomy with gastric pull-up between 2007 and 2019. The cohort was stratified in various ways to determine if postoperative care and outcomes differed, including patient demographics, comorbidities, intraoperative and postoperative procedures. Results During the study period, 149 patients underwent esophagectomy and 37 had diabetes. Overall incidence of DGE, as defined in this study, was 76.5%. Surgery type was significantly different between DGE and normal emptying cohorts ( P = 0.005). Comparing diabetic and nondiabetic patients, there was no significant difference noted in DGE ( P = 0.25). Additionally, there was no difference in presence of DGE for patients who underwent any intraoperative pyloric procedure compared to those who did not ( P = 0.36). Of significance, all 16 patients with chronic obstructive pulmonary disease had a delay in gastric emptying ( P = 0.01). Conclusions A higher proportion of patients with DGE post-esophagectomy were identified compared to the literature. There is little consensus on a true definition of DGE, but we believe this definition identifies patients suffering in the immediate postoperative period and in follow-up. There is no evidence to support a different postoperative course for patients with diabetes, but the link between chronic obstructive pulmonary disease and DGE warrants further investigation.

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