Establishment of a prediction method for premature rupture of membranes in term pregnancy using active ceruloplasmin in cervicovaginal secretion as a clinical marker

2005 ◽  
Vol 31 (5) ◽  
pp. 421-426 ◽  
Author(s):  
Mitsuharu Ogino ◽  
Shuichi Hiyamuta ◽  
Masako Takatsuji-Okawa ◽  
Yasuhiro Tomooka ◽  
Shigeki Minoura
2016 ◽  
Vol 26 (1) ◽  
pp. 23-30
Author(s):  
İlke TOPDAĞI AYDIN ◽  
Halenur BOZDAĞ ◽  
Egemen AYDIN ◽  
Sedef KABACA ◽  
Fulya GÖKDAĞLI ◽  
...  

2018 ◽  
Vol 2 (2) ◽  
pp. 101-108
Author(s):  
Defrin Defrin ◽  
Rosfita Rasyid

Premature rupture of membranes is the most common complication of pregnancy. The incidence of premature rupture of membranes in pregnancy ranged from 6% to 10%, and 20% of these cases occur before 37 weeks gestation. The incidence of premature rupture of membranes in Indonesia ranges from 4.5% to 7.6% of all pregnancies. This research was conducted to determine the cross-sectional differences in the blood plasma levels of vitamin C in term pregnancy premature rupture of membranes with blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes in M. Jam- il Padang hospital, Achmad Muchtar Bukittinggi hospital, and Pariaman Hospital. There are significant differences in vitamin C blood plasma levels in term pregnancy with premature rupture of membranes and term pregnancy without premature rupture of membranes ( P < 0.05). Mean levels of vitamin C in blood plasma at term pregnancy with premature rupture of membranes lower than in the blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes.Keywords: Premature rupture of membrane in aterm, blood plasma levels of vitamin C


2013 ◽  
Vol 62 (6) ◽  
pp. 12-18
Author(s):  
Vyacheslav Mihailovich Bolotsky

In current article the management of pregnancy and labor with premature rupture of membranes in term pregnancies and pathogenesis of premature rupture of membranes is discussed. The stimulation of labor in 2-3 hours after premature rupture of membranes without biological readiness for labor is not reasonable. In such cases active-observation tactic with antigestagens treatment and adequate antibacterial therapy helps to decrease the number of pathological labor, cesarean section and obstetrical trauma.


2017 ◽  
Vol 4 (4) ◽  
pp. 187-193
Author(s):  
V. V Astafev ◽  
S. V Nazarova ◽  
A. D Li ◽  
N. M Podzolkova

Premature rupture of membranes (PRM) during full-term pregnancy is a common obstetric complication. Childbirths on the background of PRM are accompanied by an increase in the frequency of the operative deliveries, as well as various obstetric complications. However, for all the diversity of tactics, techniques, clinical recommendations devoted to actions of a doctor in the management of PRM patients, the question of their choice depends on many factors. For more than 20 years of studying the PRM problem, a technique for preparing the cervix, providing 100% result has not been developed. With all the variety of choice of methods, none of them is devoid of shortcomings (contraindications to the use, cost-effectiveness, compliance of the patient, etc.). In this regard, the optimal choice of the tactics of labor in PRM cases is the insurance of the preservation of the health of the future generation.


2020 ◽  
Vol 18 (2) ◽  
pp. 35-41
Author(s):  
M. A. KAGANOVA ◽  
◽  
N. V. SPIRIDONOVA ◽  
O. O. DEVYATOVA ◽  
◽  
...  

Author(s):  
Aji P Wibowo ◽  
Sri Sulistyowati ◽  
Supriyadi H Respati

Objective: To examine the difference between matrix metalloproteinase‐ 9 (MMP‐9) and Tumor Necrosis Factor 􀁃 (TNF‐􀁃) serum levels in preterm and term premature rupture of membranes (PROM). Method: Our study employed an observational cross sectional approach. Seventy samples were divided into two groups, 35 samples with preterm PROM (28‐36 weeks gestational age) and 35 samples with PROM at term pregnancy (37‐42 weeks gestational age). Both groups underwent examination for serum MMP‐9 and TNF‐􀁃 concentration using ELISA method. Statistical analysis was done using ttest. Result: Serum levels of MMP‐9 in the preterm PROM group was 2860.68K627.32 ng/ml, which was significantly higher than in the PROM at term pregnancy group 2549.74K657.15 ng/ml (p=0.04). Likewise, the average serum level of TNF‐􀁃 in subjects with preterm PROM was 12,086.60K5384.51 ng/ml, significantly higher in comparison to PROM at term pregnancy, which was 6422.51K2645.32 ng/ml (p=0.00). Conclusion: Serum levels of MMP‐9 and TNF‐􀁃 in preterm PROM is significantly higher than that in PROM at term pregnancy. Keywords: MMP‐9, premature rupture of membranes, preterm, term, TNF‐􀁃


2016 ◽  
Vol 65 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Vyacheslav M Bolotskih ◽  
Marina H Afanasieva ◽  
Tatiana U Kuzminykh

The comparative analysis of outcomes of term delivery has been performed in this paper depending on the approach to labor induction affected by the premature rupture of membranes (PROM). A significant improvement in obstetric indicators has been revealed in case of prescription of Mifepristone 6 hours before the labor induction. The deterioration of obstetric indicators with patients with PROM when inducing labor in connection with the lack of biological readiness for delivery has been shown.


2020 ◽  
Vol 48 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Mateusz Mikołajczyk ◽  
Przemysław Wirstlein ◽  
Magdalena Adamczyk ◽  
Jana Skrzypczak ◽  
Ewa Wender-Ożegowska

AbstractBackgroundPreterm premature rupture of membranes (pPROM) is associated with a high risk of prematurity and complications of fetal inflammatory response syndrome (FIRS). The aim of the study is to determine any correlations between the concentration of selected cytokines contained in the cervicovaginal secretion eluates and in the umbilical cord plasma in patients with pPROM and to find the noninvasive markers of FIRS in order to pinpoint the optimal time of the delivery.MethodsThe study included 80 patients with pPROM between the 24th and 34th week of gestation. The cervicovaginal fluid and umbilical cord blood were collected. Interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 19 (IL-19) and tumor necrosis factor-α (TNF-α) concentrations were measured in both materials. For the statistical analysis, SigmaStat3.5 software was used.ResultsThere was no direct association in levels of IL-6, TNF-α, IL-10 and IL-19 between the cord blood and cervicovaginal secretions within the studied group. The cut-off point of IL-6 of 26.8 pg/mL in the vaginal fluid had high sensitivity and specificity in order to discriminate between newborns with and without FIRS (81.08%; 76.74%).ConclusionFurther studies are needed on a larger group of participants to demonstrate that an elevated concentration of IL-6 above 26.8 pg/mL in the cervicovaginal secretion eluate is an indirect noninvasive marker of FIRS.


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