scholarly journals Difference of Serum MMP9 and TNF 􀁃 Level in Preterm and Term Premature Rupture of Membranes

2016 ◽  
Author(s):  
Aji P Wibowo ◽  
Sri Sulistyowati ◽  
Supriyadi H Respati
Keyword(s):  
Gestational Age ◽  
Serum Levels ◽  
Premature Rupture Of Membranes ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
The Difference ◽  
Average Serum ◽  
Metalloproteinase 9 ◽  
Necrosis Factor

Objective: To examine the difference between matrix metalloproteinase‐ 9 (MMP‐9) and Tumor Necrosis Factor 􀁃 (TNF‐􀁃) serum levels in preterm and term premature rupture of membranes (PROM). Method: Our study employed an observational cross sectional approach. Seventy samples were divided into two groups, 35 samples with preterm PROM (28‐36 weeks gestational age) and 35 samples with PROM at term pregnancy (37‐42 weeks gestational age). Both groups underwent examination for serum MMP‐9 and TNF‐􀁃 concentration using ELISA method. Statistical analysis was done using ttest. Result: Serum levels of MMP‐9 in the preterm PROM group was 2860.68K627.32 ng/ml, which was significantly higher than in the PROM at term pregnancy group 2549.74K657.15 ng/ml (p=0.04). Likewise, the average serum level of TNF‐􀁃 in subjects with preterm PROM was 12,086.60K5384.51 ng/ml, significantly higher in comparison to PROM at term pregnancy, which was 6422.51K2645.32 ng/ml (p=0.00). Conclusion: Serum levels of MMP‐9 and TNF‐􀁃 in preterm PROM is significantly higher than that in PROM at term pregnancy. Keywords: MMP‐9, premature rupture of membranes, preterm, term, TNF‐􀁃

scholarly journals The Role of Tumor Necrosis Factor  (TNF ) and Matrix Metalloproteinase9 (MMP9) Serum in Preterm Premature Rupture of Membranes

2017 ◽  
pp. 199
Author(s):  
Ardiles Ardiles ◽  
Desmiwarti Desmiwarti ◽  
Hafni Bachtiar
Keyword(s):  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Preterm Premature Rupture ◽  
The Mean ◽  
Necrosis Factor

Objective: To investigate the role of TNF- and MMP-9 serum in preterm premature rupture of membranes (PPROM). Methods: We used cross-sectional study design. Subjects were all pregnant women with and without PPROM who underwent checkup at Obstetrics and Gynecology Functional Medical Staff General Hospital Dr. M. Djamil and networking hospital. Results: A total of 48 subjects were enrolled in this study. The mean serum levels of TNF- in patients with PPROM 17.43 ng/ml  12.4 ng/ml and without PPROM 8.45 ng/ml  6.86 ng/ml. The mean serum levels of MMP-9 in patients with PPROM 8.77 ng/ml  4.41 ng/ml, and without PPROM 4.46 ng/ml  3.04 ng/ml. Statistical test result p value <0.05, it can be conclude there are differences in the levels of TNF- and MMP-9 serum in premature rupture of membranes and without premature rupture of membranes pregnancy of preterm. Conclusion: There are differences in the levels of TNF- and MMP-9 serum in PPROM and without PPROM.Keywords: MMP-9, premature rupture of membranes, TNF-

Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes

2016 ◽  
Vol 44 (5) ◽  
Author(s):  
Joohee Choi ◽  
Jeong Woo Park ◽  
Byoung Jae Kim ◽  
Ye-Jin Choi ◽  
Jong Hee Hwang ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gestational Age ◽  
Preterm Labor ◽  
Cervical Insufficiency ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Histologic Chorioamnionitis ◽  
Gestational Age At Delivery ◽  
The Difference

AbstractTo compare the frequency of histologic chorioamnionitis and funisitis among women experiencing preterm labor, preterm premature rupture of membranes (PROM) and cervical insufficiency.This retrospective cohort study included singleton pregnant women who delivered at ≤36 weeks of gestation. The patients with preterm birth were subdivided into preterm labor (n=117), preterm PROM (n=153), and cervical insufficiency (n=20). All placentas were examined for pathology, according to the criteria of1) Histologic chorioamnionitis was diagnosed in 48.7% (57/117) of cases with preterm labor, 47.4% (73/153) with preterm PROM, and 75.0% (15/20) with cervical insufficiency. Funisitis was detected in 11.1% (13/117) of cases with preterm labor, 15.7% (24/153) with preterm PROM, and 40.0% (8/20) with cervical insufficiency. 2) Frequency of histologic chorioamnionitis was higher in cases with cervical insufficiency compared to preterm PROM. Frequency of funisitis was higher in cases with cervical insufficiency compared to both preterm labor and preterm PROM (P<0.05). The difference in frequency of funisitis remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis. 3) Frequency of grade 2 funisitis was higher in cases with cervical insufficiency (35.0%, 7/20) compared to both preterm labor (6.8%, 8/117) and preterm PROM (9.8%, 15/153) (P=0.001). And the difference remained significant after adjustment for gestational age at delivery and cervical dilatation at diagnosis.: The highest frequency of funisitis was observed in cervical insufficiency among cases with spontaneous preterm birth.

scholarly journals PERBANDINGAN ANTARA KADAR VITAMIN C PLASMA DARAH HAMIL ATERM PADA KETUBAN PECAH DINI DENGAN HAMIL ATERM TANPA KETUBAN PECAH DINI

2018 ◽  
Vol 2 (2) ◽  
pp. 101-108
Author(s):  
Defrin Defrin ◽  
Rosfita Rasyid
Keyword(s):  
Vitamin C ◽  
Blood Plasma ◽  
Plasma Levels ◽  
Common Complication ◽  
Premature Rupture Of Membranes ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
In Pregnancy ◽  
In Blood Plasma

Premature rupture of membranes is the most common complication of pregnancy. The incidence of premature rupture of membranes in pregnancy ranged from 6% to 10%, and 20% of these cases occur before 37 weeks gestation. The incidence of premature rupture of membranes in Indonesia ranges from 4.5% to 7.6% of all pregnancies. This research was conducted to determine the cross-sectional differences in the blood plasma levels of vitamin C in term pregnancy premature rupture of membranes with blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes in M. Jam- il Padang hospital, Achmad Muchtar Bukittinggi hospital, and Pariaman Hospital. There are significant differences in vitamin C blood plasma levels in term pregnancy with premature rupture of membranes and term pregnancy without premature rupture of membranes ( P < 0.05). Mean levels of vitamin C in blood plasma at term pregnancy with premature rupture of membranes lower than in the blood plasma levels of vitamin C in term pregnancy without premature rupture of membranes.Keywords: Premature rupture of membrane in aterm, blood plasma levels of vitamin C

scholarly journals Predictors of Premature Rupture of Membranes among Pregnant Women in Rural Uganda: A Cross-Sectional Study at a Tertiary Teaching Hospital

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Simon Byonanuwe ◽  
Emmanuel Nzabandora ◽  
Baltazar Nyongozi ◽  
Theophilus Pius ◽  
David Santson Ayebare ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Pregnant Women ◽  
Gestational Age ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
History Of ◽  
Tract Infections

Background. Premature rupture of membranes (PROM) is a common condition in developed and developing countries and poses a serious threat to the maternal and fetal well-being if not properly managed. This study delineated the prevalence and predictors of PROM in the western part of Uganda so as to guide specific preventive measures. Methods. A cross-sectional study design was conducted in the months of September 2019 to November 2019. A total of 334 pregnant women above 28 weeks of gestation admitted at the maternity ward of KIU-TH were consecutively enrolled. Interviewer-administered questionnaires were used to obtain the data. Descriptive statistics followed by binary logistic regression were conducted. All data analyses were conducted using STATA 14.2. Results. Of the 334 pregnant women enrolled, the prevalence of PROM was found to be 13.8%. The significant independent predictors associated with lower odds of PROM were no history of urinary tract infection (UTI) in the month preceding enrollment into the study (aOR=0.5, 95% CI: 0.22-0.69, p=0.038) and gestational age of 37 weeks or more (aOR=0.3, 95% CI: 0.14-0.71, p=0.01) while history of 3 or more abortions (aOR=13.1, 95% CI: 1.12-153.62, p=0.05) was associated with higher likelihood of PROM. Conclusions. Majorly urinary tract infections, low gestational age, and abortions influence premature rupture of membranes among women. There is a great need for continuous screening and prompt treatment of pregnant women for UTI especially those with history of 3 or more abortions at less than 34 weeks of gestation.

scholarly journals KARAKTERISTIK KEHAMILAN DENGAN KETUBAN PECAH DINI PRETERM DI RSUD ULIN BANJARMASIN

2019 ◽  
Vol 6 (1) ◽  
Author(s):  
Hermin Sabaruddin ◽  
Chalid Muthaher ◽  
M. Robyanoor AR
Keyword(s):  
Gestational Age ◽  
Medical Records ◽  
Maternal Age ◽  
Education Level ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Preterm Premature Rupture ◽  
Low Education

ABSTRAKKetuban pecah dini (KPD) didefinisikan sebagai pecahnya selaput ketuban sebelum terjadinya persalinan yang terjadi pada atau setelah usia gestasi 37 minggu disebut KPD aterm atau premature rupture of membranes (PROM) dan sebelum usia gestasi 37 minggu atau KPD preterm atau preterm premature rupture of membranes (PPROM). Insiden ketuban pecah dini di Indonesia berkisar 4,5% sampai 7,6 % dari seluruh kehamilan. KPD Preterm terjadi pada terjadi pada sekitar 2-3% dari semua kehamilan tunggal dan 7,4% dari kehamilan kembar. Penelitian ini merupakan penelitian observasional analitik secara retrospektif deskriptif cross sectional. Pengambilan data diambil dari rekam medis pasien rawat inap kamar bersalin di RSUD.Ulin Banjarmasin pada periode januari– desember 2017. Pada penelitian ini menunjukkan bahwa sebagian besar variabel faktor risiko yaitu usia, pendidikan, usia kehamilan dan paritas menunjukkan hubungan terhadap kejadian KPD preterm. Hasil analisis menunjukkan terdapat hubungan yang signifikan pada usia ibu 18-20 tahun sebesar 63.6% dengan OR (95%CI)= 7.56 (6.206-7.687). Faktor risiko pada sampel pendidikan paling banyak pada tingkat pendidikan rendah sebesar 65,1% dengan OR (95% CI) = 7.244 (6.172-7.343) dibandingkan dengan ibu tingkat pendidikan tinggi sebesar 37.3%. Pada variable usia kehamilan sampel terbanyak ditemukan pada usia kehamilan 28-34 minggu sebanyak 100% dengan OR (95%CI) = 94.0 (78.2-130.3). Pada variabel paritas terbanyak pada multigravida yaitu 45.9% dengan OR (95%CI) = 2.26-2.32) namun hasil ini tidak signifikan dikarenakan p value >0.005. Ditemukan hubungan faktor risiko pada usia ibu 18-20 tahun, pendidikan rendah, dengan usia kehamilan 28-34 minggu, namun tidak signifikan pada paritas multigravida.Kata-kata kunci : Ketuban pecah dini preterm, kehamilan ABSTRACTPremature rupture of membranes (PROM) are defined as rupture of the membranes before the onset of labor and which occur at or after 37 weeks gestational age is called premature rupture of membranes (PROM) and before 37 weeks gestational age is called preterm premature rupture of membranes (PPROM). The incidence of premature rupture of membranes in Indonesia is from 4.5% to 7.6% of all pregnancies. Preterm KPD occurs at 2-3% of all single pregnancy and 7.4% of twin pregnancy. This study was a cross sectional descriptive observational analytic study. The data was taken from the medical records of Delivery Room in RSUD Ulin Banjarmasin at January-December 2017. In this study, the majority of risk factor, age, education, gestational age and parity showed a relationship to Insidence of PPROM. The results of the analysis showed that there was a significant relationship between the age of 18-20 years percentage was 63.6% with OR (95% CI) = 7.56 (6,206-7,687). The most sample at low education level was 65,1% with OR (95% CI) = 7.244 (6.172-7.343) compared to the high education level was 37.3%. Criteria for gestational age, the most samples were found at 28-34 weeks gestational age with percentage of PPROM was 100% with OR (95% CI) = 94.0 (78.2-130.3). Then at parity most Insidece in multigravida was 45.9% with OR (95% CI) = 2.26-2.32) but this result is not significant because p value> 0.005. We found a correlation between risk factors at maternal age 18-20 years, the low education and gestational age of 28-34 weeks, but not significant in multigravida parity.Keywords : Preterm premature rupture of membranes (PPROM), pregnancy

scholarly journals The Difference of Zinc And Matrix Levels of Metalloproteinase-9 Serum Between Premature Rupture Of Membrane Aterm And Normal Pregnancy

2019 ◽  
Vol 4 (1) ◽  
pp. 40
Author(s):  
Lisa Ernita ◽  
Ellyza Nasrul ◽  
Andi Friadi
Keyword(s):  
Serum Zinc ◽  
Normal Pregnancy ◽  
Zinc Level ◽  
Independent Practice ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Membrane Rupture ◽  
The Difference ◽  
Zinc Levels

Premature rupture of membranes (PROM) is one of the common problems in the obstetric field, ranging from 8-10% of term pregnancies will experience PROM. The increase in MMP-9 also has an impact on the degradation of the extracellular matrix and the apoptotic process of amniotic epithelial cells which ultimately leads to membrane rupture. The purpose of this study was to determine the differences in serum zinc and MMP-9 levels between premature rupture of membranes and normal pregnancies.This research is quantitative observational with the cross-sectional design carried out in Independent Practice Midwives for research samples of term premature rupture of normal and amniotic pregnancies, and Biomedical Laboratory of the Medical Faculty of Andalas University in March 2018 to March 2019. The research sample amounted to 35 respondents using consecutive sampling. Zinc and MMP-9 levels were examined by the Human ELISA Kit. Data analysis using the unpaired t-test.The results showed a mean serum zinc level of 13608 ± 1128.976µg / ml in Aterm KPD and 13799,111 ± 1254,335 µg / ml in normal pregnancies with p> 0.05. The mean serum MMP-9 levels were 1682.412 ± 320,398 ng / ml in Aterm PROM and 1807,667 ± 484,735 ng / ml in normal pregnancies with p <0.05.This study concludes that there is no difference in serum zinc levels in premature rupture of membranes and normal pregnancies; there is a difference in MMP-9 levels in premature rupture of membranes and normal pregnancy. 

scholarly journals Analysis of the factors affecting the duration of the latent period from the moment of prelabor rupture of membranes to the onset of labor

2020 ◽  
Vol 20 (5-6) ◽  
pp. 15-24
Author(s):  
Maria A. Kaganova ◽  
Natalya V. Spiridonova
Keyword(s):  
Amniotic Fluid ◽  
Latent Period ◽  
Gestational Age ◽  
Latency Period ◽  
Full Term ◽  
Premature Rupture Of Membranes ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Latency Interval ◽  
The Moment

Introduction. Premature rupture of membranes during full-term pregnancy represents an increased risk of septic complications for both the mother and the fetus due to the prolongation of the latency period, the period from the discharge of amniotic fluid till the onset of labor. Purpose of the study: to assess the factors affecting the duration of the latent period (from the moment of discharge of amniotic fluid to the development of labor) during full-term pregnancy. Materials and methods. A prospective analysis of the labor of 136 patients with premature rupture of membranes and full-term pregnancy (37-42 weeks) of low and moderate risk groups, without contraindications for vaginal birth was carried out. Patients with Bishops cervical score less than or equal to 7 points made up the main group (70 pregnant women). Patients with mature cervix were included in the comparison group (66 cases). The analysis of the duration of the latent period was carried out with the use of correlation and regression analysis. Results. The time from the moment of discharge of amniotic fluid to the onset of regular labor in the group with a cervix 7 Bishop points was 7.82 4.53 hours, while in the group with a cervix 8 Bishop points it was 4.4 3.23 hours (T = 5.02; p 0.001). The most significant effect on the duration of the latency period was the assessment of the cervix according to Bishop scale (r = 0.48; p 0.001), the gestational age was in the second place (r = 0.23; p = 0.08). In patients who didnt take mifepristone, the main factors influencing the duration of the latency interval were fetal weight (r = 0.31; p = 0.004) and gestational age (r = 0.29; p = 0.008); the increase in these parameters led to the decrease in the latency interval. Women who received 200 mg mifepristone in labour had a significant positive correlation with maternal age (r = 0.36; p = 0.04), negative with maternal weight (r = 0.42; p = 0.01) and cervical Bishop score (r = 0.48; p = 0.004). Women in labor with the longest latency interval, who received mifepristone in a daily dosage of 400 mg, have an inverse correlation for the gestational age (r = 0.39; p = 0.09), connection with the degree of cervical maturity, age, constitutional features, gestational age was not revealed. Conclusion. The main predictors of the duration of the latency period of premature rupture of membranes at full-term pregnancy were the degree of cervical maturity according to Bishop scale, gestational age and fetal weight at birth.

scholarly journals The Difference of Asphyxia Neonatorum Incident between Very Preterm Labor That Is Followed or Not by Premature Rupture of Membranes at RSD dr. Soebandi of Jember

2018 ◽  
Vol 4 (3) ◽  
pp. 147
Author(s):  
Nely Masruroh ◽  
Yonas Hadisubroto ◽  
Rena Normasari
Keyword(s):  
Preterm Labor ◽  
P Value ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Chi Square ◽  
Cross Sectional ◽  
Asphyxia Neonatorum ◽  
Very Preterm ◽  
Significant Difference ◽  
The Difference

Asphyxia neonatorum is an infant's inability to breathe spontaneously and regularly soon after birth. Risk factors of neonatal asphyxia are preterm labor and premature rupture of membranes. In the poor and developing countries there are many occurrences of asphyxia at gestation less than 32 weeks (very preterm). The aim of this study is to describe the incidence of asphyxia neonatorum in very preterm labor followed by premature rupture of membranes, describes the incidence of asphyxia neonatorum in very preterm labor that is not followed by premature rupture of membranes, and the difference of asphyxia neonatorum incident between very preterm labor that is followed or not by premature rupture of membranes. The type of this research was retrospective analytical observational with cross sectional approach and total sampling technique. The population was a single preterm delivery mother with spontaneous presentation of heads born in RSD dr. Soebandi from January 2015 - January 2017. From 465 mothers, 65 mothers meet the inclusion criteria. Data is processed and presented in the form of frequency distribution table then analyzed using Chi-Square test. The results showed that mothers with very preterm followed by premature rupture of membranes did not have asphyxia (22 mothers or 33.8%) and mothers with very preterm that is not followed by premature rupture of membranes did not have asphyxia (18 mothers or 27.2%). Based on Chi-Square statistical test results obtained p-value (0.298)> α (0.05) and it can be concluded that is statistically at 95% confidence level there is no significant difference in the incident of asphyxia neonatorum between very preterm labor that is followed or not by premature rupture of membranes in RSD dr. Soebandi Kabupaten Jember.Keywords: Asphyxia neonatorum, preterm labor, premature rupture of membranes

scholarly journals Risk Factors for Premature Rupture of the Membranes

2020 ◽  
Vol 6 (2) ◽  
pp. 35-43
Author(s):  
Lilin Turlina ◽  
Faizatul Ummah ◽  
Sulistyowati
Keyword(s):  
Risk Factors ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
P Value ◽  
Multiple Logistic Regression ◽  
Premature Rupture Of Membranes ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Patient Medical Record

The incidence of premature rupture of membranes (PRM) ranges from 8-10% at term pregnancy and 1% in preterm pregnancy. The incidence of PRM at RSUD dr. SoegiriLamongan in 2017 amounted to 16,43%. The purpose of this study was to analyze risk factors of the occurrence of premature rupture membranes in RSUD Dr. SoegiriLamongan. The research used descriptive analytical method with cross sectional approach. The sample is 268 maternity mothers, divided into 134 mothers giving birth with PRM  and 134 normal maternity mothers at Dr. Soegiri Lamongan on 2018. Sampling is done by simple random sampling. Data collection uses patient medical record and with multivariate multiple logistic regression analysis.The results showed that presentation abnormalities with a p value of 0.045 <0.05 and CPD with a p value of 0.002 <0.05. Based on the Odds Ratio (OR) values ​​as follows: Maternal age OR 1,141, OR parity 0.933, OR fetal presentation 2,779, OR Twins 1,394, OR CPD 6. and OR Large infants 0.783.Meaning that there was a significant influence between fetal presentation and CPD on PRM.

Sign in / Sign up

Export Citation Format

Share Document