HLA-DRB1 alleles are associated with the clinical course of disease and steroid dependence in Mexican patients with ulcerative colitis

2010 ◽  
Vol 12 (12) ◽  
pp. 1231-1235 ◽  
Author(s):  
J. K. Yamamoto-Furusho ◽  
L. Rodríguez-Bores ◽  
J. Granados
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Course ◽  
Course Of Disease ◽  
Steroid Dependence ◽  
Mexican Patients

Multi-dimensional Visualisation of Laboratory Findings and Functional Test Results for Analysing the Clinical Course of Disease in Medicine

1995 ◽  
Vol 34 (03) ◽  
pp. 302-308 ◽  
Author(s):  
C. J. Luz ◽  
W. Giere ◽  
R. Lüdecke ◽  
D. Jonas ◽  
A. J. W. Goldschmidt
Keyword(s):  
Clinical Course ◽  
Test Results ◽  
Geometrical Figure ◽  
Laboratory Findings ◽  
Course Of Disease ◽  
Quantitative Examination ◽  
Ward Rounds ◽  
Patient’S History ◽  
Graphical Primitive ◽  
Computerized Medical Record

Abstract:The illustration of a patient’s history by a graphical primitive is discussed. Illustration technology is presented which simultaneously represents quantitative examination findings (e. g., laboratory values) and qualitative findings (e. g., from function diagnostics) by a single geometrical figure. Depending on the medical results, this figure takes on characteristic forms which can be identified as patterns typical for a specific disease. The procedure developed is integrated in a user interface which is implemented in the form of a computerized medical record for use on a pentop computer. This portable computer assists the physician during ward rounds, supplies additional, intelligence-based information, serves quality control, and streamlines working procedures making them more efficient.

scholarly journals Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sabine A. Hartlieb ◽  
Lina Sieverling ◽  
Michal Nadler-Holly ◽  
Matthias Ziehm ◽  
Umut H. Toprak ◽  
...  
Keyword(s):  
High Frequency ◽  
Clinical Course ◽  
Population Based ◽  
Telomeric Repeat ◽  
Telomere Maintenance ◽  
Study Cohort ◽  
Alternative Lengthening Of Telomeres ◽  
Course Of Disease ◽  
Low Protein ◽  
Alternative Lengthening

AbstractTelomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas (n = 760) and characterize its features using multi-omics profiling. ALT-positive tumors are molecularly distinct from other neuroblastoma subtypes and enriched in a population-based clinical sequencing study cohort for relapsed cases. They display reduced ATRX/DAXX complex abundance, due to either ATRX mutations (55%) or low protein expression. The heterochromatic histone mark H3K9me3 recognized by ATRX is enriched at the telomeres of ALT-positive tumors. Notably, we find a high frequency of telomeric repeat loci with a neuroblastoma ALT-specific hotspot on chr1q42.2 and loss of the adjacent chromosomal segment forming a neo-telomere. ALT-positive neuroblastomas proliferate slowly, which is reflected by a protracted clinical course of disease. Nevertheless, children with an ALT-positive neuroblastoma have dismal outcome.

Fecal Calprotectin Predicts the Clinical Course of Acute Severe Ulcerative Colitis

2009 ◽  
Vol 104 (3) ◽  
pp. 673-678 ◽  
Author(s):  
G T Ho ◽  
H M Lee ◽  
G Brydon ◽  
T Ting ◽  
N Hare ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Course ◽  
Fecal Calprotectin ◽  
Severe Ulcerative Colitis

scholarly journals P566 Clinical course of severe colitis; a comparison between Crohn's colitis and ulcerative colitis

2013 ◽  
Vol 7 ◽  
pp. S237
Author(s):  
E. Sinagra ◽  
F. Mocciaro ◽  
A. Scalisi ◽  
V. Criscuoli ◽  
A. Orlando ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Course ◽  
Crohn’S Colitis ◽  
Crohn's Colitis ◽  
Severe Colitis
Sign in / Sign up

Export Citation Format

Share Document