Faecal Lactoferrin, Calprotectin, PMN-elastase, CRP, and White Blood Cell Count as Indicators for Mucosal Healing and Clinical Course of Disease in Patients with Mild to Moderate Ulcerative Colitis: Post Hoc Analysis of a Prospective Clinical Trial

Background and Aim: To evaluate the onset of symptomatic response with vedolizumab in patients with moderate-to-severe ulcerative colitis in Japan. Methods: Patients were randomized to receive vedolizumab 300 mg or placebo at Weeks 0, 2, and 6. Mayo subscores were analyzed in patients with baseline stool frequency (SF) ≥1 and rectal bleeding (RB) ≥1. In patients with baseline SF ≥2 and RB ≥1, the proportion who achieved SF ≤1 and RB = 0 was determined. Results: Patients were randomized to vedolizumab (n = 164) or placebo (n = 82). Decrease from baseline in mean SF subscore was greater with vedolizumab versus placebo from Week 2 (−6.6%; 95% confidence interval [CI], −16.2, 3.0), with a greater difference in anti-tumor necrosis factor (TNF)α-naive patients (vedolizumab vs. placebo, −13.2%; 95% CI, −29.7, 3.3). Mean percentage decrease from baseline RB subscore was numerically greater with vedolizumab versus placebo from Week 6 in anti-TNFα-naive patients (−10.7%; 95% CI, −33.0, 11.5). More patients in the anti-TNFα-naive subgroup achieved SF ≤1 and RB = 0 with vedolizumab versus placebo at Week 2 (14.8%; 95% CI, 2.5, 27.0) and Week 6 (20.3%; 95% CI, 4.4, 36.2). Patients with SF ≤1 and RB = 0 at Week 2 had higher clinical response, clinical remission, and mucosal healing rates at Week 10 than those without. Conclusions: Our results indicate that vedolizumab induces a rapid symptomatic response, particularly in anti-TNFα-naive patients, and suggest that early symptomatic improvement predicts treatment response at Week 10 (NCT02039505).

Download Full-text

Bacille Calmette-Guérin vaccination at birth and differential white blood cell count in infancy. A randomised clinical trial

Vaccine ◽

10.1016/j.vaccine.2020.02.006 ◽

2020 ◽

Vol 38 (11) ◽

pp. 2449-2455

Author(s):

Signe Kjeldgaard Jensen ◽

Trine Mølbæk Jensen ◽

Nina Marie Birk ◽

Lone Graff Stensballe ◽

Christine Stabell Benn ◽

...

Keyword(s):

Clinical Trial ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Randomised Clinical Trial ◽

Blood Cell Count ◽

Bacille Calmette Guerin ◽

Differential White Blood Cell

Download Full-text

P485 Fecal lactoferrin, calprotectin, PMN-elastase, CRP and white blood count as indicator for clinical course of disease and mucosal healing in patients with ulcerative colitis: A prospective 12-month monitoring study

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(14)60605-x ◽

2014 ◽

Vol 8 ◽

pp. S269

Author(s):

J. Langhorst ◽

J.H. Boone ◽

R. Lauche ◽

A. Rüffer ◽

G.J. Dobos

Keyword(s):

Ulcerative Colitis ◽

Blood Count ◽

Clinical Course ◽

Mucosal Healing ◽

White Blood Count ◽

Course Of Disease ◽

Fecal Lactoferrin ◽

Pmn Elastase ◽

Monitoring Study ◽

Pmn Élastase

Download Full-text

Analysis of Association Between Dietary Intake and Red Blood Cell Count Results in Remission Ulcerative Colitis Individuals

Medicina ◽

10.3390/medicina55040096 ◽

2019 ◽

Vol 55 (4) ◽

pp. 96 ◽

Cited By ~ 2

Author(s):

Dominika Głąbska ◽

Dominika Guzek ◽

Barbara Kanarek ◽

Gustaw Lech

Keyword(s):

Ulcerative Colitis ◽

Blood Cell ◽

Cell Count ◽

Red Blood Cell ◽

Meat Products ◽

Control Group ◽

Iron Intake ◽

Blood Cell Count ◽

Animal Products ◽

Red Blood Cell Count

Background and objectives: The anemia is the most common extra-intestinal manifestation of the ulcerative colitis. Taking into account, that meat products are perceived as factor, that may promote relapses, the crucial is to indicate the dietary recommendations to prevent anemia development but without high animal products intake. Aim of the study was to analyze the influence of animal products intake on the red blood cell count results in remission ulcerative colitis individuals and pair-matched control group, during 6 weeks of observation. Materials and Methods: The intake of nutrients associated with anemia development (iron, vitamin B12, protein, animal protein, calcium) and the products being their sources (meat, meat products, dairy beverages, cottage cheese, rennet cheese) were analyzed. Results: In spite of the higher meat products intake in the group of ulcerative colitis individuals, the iron intake did not differ between groups. The positive correlations between intakes of meat, meat products, total protein, animal protein, iron, vitamin B12 and red blood cell count results were stated for ulcerative colitis individuals, while in control group were not observed, that may have resulted from higher susceptibility for the diet-influenced changes. Conclusions: The positive correlation between red blood cell count results and energy value of diet, and daily iron intake observed in ulcerative colitis individuals, accompanied by negative correlation for iron intake per 1000 kcal of diet, may indicate, that higher iron intake may be beneficial, but only while accompanied by high energy value of diet.

Download Full-text

P2212 A comparative study of white blood cell count, neopterin and C-reactive protein for prediction of stenosis complexity in patients with non-ST-segement elevation acute coronary syndromes

European Heart Journal ◽

10.1016/s0195-668x(03)95206-7 ◽

2003 ◽

Vol 24 (5) ◽

pp. 420

Author(s):

P AVANZAS

Keyword(s):

Blood Cell ◽

Comparative Study ◽

Cell Count ◽

White Blood Cell Count ◽

White Blood Cell ◽

Acute Coronary Syndromes ◽

C Reactive Protein ◽

Blood Cell Count ◽

Reactive Protein ◽

Coronary Syndromes

Download Full-text

Cigarette Smoking Increases Thromboxane A2 Formation without Affecting Platelet Survival in Young Healthy Females

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646321 ◽

1992 ◽

Vol 68 (05) ◽

pp. 583-588 ◽

Cited By ~ 25

Author(s):

Annika Dotevall ◽

Christina Rångemark ◽

Elsa Eriksson ◽

Jack Kutti ◽

Hans Wadenvik ◽

...

Keyword(s):

Cardiovascular Disease ◽

Cigarette Smoking ◽

Blood Cell ◽

Urinary Excretion ◽

Life Span ◽

Cell Count ◽

Thromboxane A2 ◽

Blood Cell Count ◽

Platelet Activity ◽

Pai 1

SummarySmoking is a risk factor for the development of atherosclerotic cardiovascular disease, in men as well as in women. An increased urinary excretion of the thromboxane metabolite 2,3-dinor-thromboxane B2 (Tx-M) has been observed in smokers of both genders, suggesting that cigarette smoking may facilitate cardiovascular disease via an action on the platelets. The present study addressed the hypothesis that the increased Tx-M excretion in female smokers reflects a true facilitation of platelet reactivity in vivo, rather than an increased destruction of the platelets. In healthy female volunteers (aged 20–46 years, 18 smokers and 17 non-smokers) platelet life-span and indices of platelet activity were determined, together with plasma levels of plasminogen activator inhibitor-1 (PAI-1), fibrinogen, peripheral blood cell counts and hematocrit. The urinary excretion of Tx-M was higher in smokers than in non-smokers (361 vs. 204 pg/mg creatinine, respectively, p <0.05), while plasma and urinary β-thromboglobulin, plasma platelet factor 4, platelet mean life-span and platelet production rate did not differ between the groups. PAI-1 activity, white blood cell count and hematocrit were higher in smokers than in non-smokers (p <0.05). These data indicate that smoking facilitates platelet formation of thromboxane A2 without affecting platelet survival; i.e. it increases the activity of platelets without affecting their viability to a measurable extent. Such an increase in platelet activity, operating in parallel to a reduced fibrinolytic activity and a higher hematocrit and white blood cell count, may play an etiological role in smoking-induced cardiovascular disease in women.

Download Full-text