Lack of Association between the 3092 T°C Clock Gene Polymorphism and Cluster Headache

Cephalalgia ◽  
2005 ◽  
Vol 25 (11) ◽  
pp. 1078-1081 ◽  
Author(s):  
I Rainero ◽  
C Rivoiro ◽  
S Gallone ◽  
W Valfrè ◽  
M Ferrero ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Cluster Headache ◽  
Association Study ◽  
Clinical Features ◽  
Clock Gene ◽  
Genetic Factors ◽  
Allele Frequencies ◽  
Headache Disorders ◽  
Number Of Genes

Recent studies suggested that genetic factors play a role in cluster headache (CH). However, the type and the number of genes involved in the disease are still unclear. We performed an association study in a cohort of Italian CH patients to evaluate whether a particular allele or genotype of the Clock gene would modify the occurrence and the clinical features of the disease. One hundred and seven CH patients, diagnosed according to the International Classification of Headache Disorders, 2nd Edition, (ICHD-II) criteria, and 210 healthy age, sex and ethnicity-matched controls were genotyped for the 3092 T°C Clock gene polymorphism (also known as 3111 T°C). Phenotype and allele frequencies were similarly distributed in CH patients and controls. The clinical features of the disease were not significantly influenced by different genotypes. In conclusion, our study suggests that the 3092 T°C polymorphism of the Clock gene is unlikely to play an important role in cluster headache.

Classification, diagnostic criteria, and epidemiology

2020 ◽  
pp. 177-181
Author(s):  
Thijs H. Dirkx ◽  
Peter J. Koehler
Keyword(s):  
Cluster Headache ◽  
Epidemiological Data ◽  
Hemicrania Continua ◽  
Paroxysmal Hemicrania ◽  
Primary Headaches ◽  
Conjunctival Injection ◽  
Headache Disorders ◽  
Cranial Autonomic Symptoms ◽  
Unilateral Headache

The trigeminal autonomic cephalalgias (TACs), including cluster headache, paroxysmal hemicrania, SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing), SUNA (with cranial autonomic symptoms), and hemicrania continua, belong to the primary headaches. They are characterized by severe unilateral headache attacks in association with ipsilateral cranial autonomic features. Cluster headache is the most frequent of the TACs. The other TACs are rare, but epidemiological data are scarce and variable. The various types of TAC are distinguished not only by differences in attack frequency and duration, but also by differences with respect to treatment response. The typical headache syndromes, fulfilling the International Classification of Headache Disorders-3 criteria, have also been described in association with other disorders and imaging is required to exclude intracranial pathology in all newly diagnosed patients.

Chronobiology differs between men and women with cluster headache, clinical phenotype does not

Neurology ◽  
2017 ◽  
Vol 88 (11) ◽  
pp. 1069-1076 ◽  
Author(s):  
Nunu Lund ◽  
Mads Barloese ◽  
Anja Petersen ◽  
Bryan Haddock ◽  
Rigmor Jensen
Keyword(s):  
Cluster Headache ◽  
Clinical Characteristics ◽  
Clinical Phenotype ◽  
Correct Diagnosis ◽  
Diagnostic Delay ◽  
Headache Disorders ◽  
Structured Interviews ◽  
Secondary Sector ◽  
Headache Center

Objective:To describe differences between the sexes in the phenotype of cluster headache (CH) in a large, well-characterized clinical CH population.Methods:Patients from the Danish CH survey aged 18–65 years, diagnosed with CH according to International Classification of Headache Disorders, second edition, completed questionnaires and structured interviews.Results:A total of 351 patients with CH participated, with a male:female ratio of 2:1. The diurnal variation of attacks showed moments of peak prominence in men’s attack cycle to be advanced by 1 hour compared to women’s, despite no difference in self-reported bedtime or chronotype (p = 0.31). The onset of CH decreased with increasing age for both sexes. Diagnostic delay was numerically longer for men vs women (6.56 vs 5.50 years, p = 0.21); however, more women had previously been misdiagnosed (61.1% vs 45.5%, p < 0.01) and received the correct diagnosis at a tertiary headache center (38.8% vs 20.9%, p < 0.001). Only minor sex differences in clinical characteristics were found but chronic CH was more prevalent in women compared to men (44.0% vs 31.9%, p < 0.05).Conclusions:Despite a similar clinical phenotype, diurnal attack cycle is advanced by 1 hour in men with CH compared to women. Rhythmicity is a defining characteristic of CH and these findings suggest differences in the hypothalamus’ influence on attack occurrence between the sexes. In addition, women were more often misdiagnosed and diagnosis in the primary or secondary sector more often failed. Furthermore, women had chronic CH more frequently than men. A long diagnostic delay and frequent misdiagnosis emphasize the need for increased awareness of CH in both sexes.

Avian Clock gene polymorphism: evidence for a latitudinal cline in allele frequencies

2007 ◽  
Vol 16 (22) ◽  
pp. 4867-4880 ◽  
Author(s):  
A. JOHNSEN ◽  
A. E. FIDLER ◽  
S. KUHN ◽  
K. L. CARTER ◽  
A. HOFFMANN ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Clock Gene ◽  
Allele Frequencies ◽  
Latitudinal Cline

Investigation of the T3111C CLOCK gene polymorphism in cluster headache

2008 ◽  
Vol 255 (2) ◽  
pp. 299-300 ◽  
Author(s):  
S. Cevoli ◽  
M. Mochi ◽  
G. Pierangeli ◽  
S. Zanigni ◽  
D. Grimaldi ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Cluster Headache ◽  
Clock Gene

Evaluation of the new ICHD-III beta cluster headache criteria

Cephalalgia ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 547-551 ◽  
Author(s):  
IF de Coo ◽  
LA Wilbrink ◽  
J Haan ◽  
MD Ferrari ◽  
GM Terwindt
Keyword(s):  
Cohort Study ◽  
Cluster Headache ◽  
Response Rate ◽  
Headache Disorders ◽  
Facial Flushing ◽  
Cross Sectional ◽  
Web Based ◽  
Additional Value ◽  
Headache Patients

Aim In the revised criteria of the International Classification of Headache Disorders (ICHD-III beta) the following items are added to the diagnostic criteria of cluster headache: ipsilateral sensation of fullness in the ear and ipsilateral forehead/facial flushing. We evaluated the possible additional value of these symptoms for diagnosing cluster headache. Methods In this cross-sectional cohort study of (potential) cluster headache patients we investigated these additional symptoms using a Web-based questionnaire. Patients not fulfilling the ICHD-II criteria for cluster headache but fulfilling the ICHD-III beta criteria were interviewed. Results Response rate was 916/1138 (80.5%). Of all 573 patients with cluster headache according to ICHD-II criteria, 192 (33.5%) reported ipsilateral ear fullness and 113 (19.7%) facial flushing during attacks. There was no difference in reporting ipsilateral ear fullness and facial flushing between patients who received a diagnosis of cluster headache and patients who did not. None of the patients who did not fulfill all ICHD-II criteria could be categorized as cluster headache according to the ICHD-III beta criteria. Conclusion The results of this study do not support the addition of ear fullness and facial flushing to the new ICHD-III beta criteria.

Field testing the diagnostic criteria of cluster headache in the third edition of the International Classification of Headache Disorders: A cross-sectional multicentre study

Cephalalgia ◽  
2019 ◽  
Vol 39 (7) ◽  
pp. 900-907 ◽  
Author(s):  
Heui-Soo Moon ◽  
Soo-Jin Cho ◽  
Byung-Kun Kim ◽  
Mi Ji Lee ◽  
Pil-Wook Chung ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Field Testing ◽  
Chronic Cluster Headache ◽  
International Classification ◽  
Headache Disorders ◽  
Cross Sectional ◽  
The Third ◽  
Accompanying Symptoms ◽  
Using Data

Background *These authors are shared first authors. The recently published third edition of the International Classification of Headache Disorders (ICHD-3) revised the criteria for accompanying symptoms of cluster headache (CH) and the remission period of chronic cluster headache (CCH). This study aimed at testing the validity of the ICHD-3 criteria for CH by using data from the Korean Cluster Headache Registry. Methods Consecutive patients with CH and probable cluster headache (PCH) were prospectively recruited from 15 hospitals. We analysed the validity of the revised ICHD-3 criteria for CH against the beta version of the third edition of the ICHD (ICHD-3β). Results In total, 193 patients were enrolled: 140 (72.5%), 5 (2.6%) and 22 (11.4%) had episodic cluster headache (ECH), CCH, and PCH, respectively. The remaining 26 (13.5%) had CH with undetermined remission periods. One patient with ECH and one with PCH had only forehead and facial flushing and were diagnosed with PCH and non-cluster headache, respectively, according to the ICHD-3. Four participants with ECH according to the ICHD-3β had remission periods of > 1 month and between 1 and 3 months and were newly diagnosed with CCH according to the ICHD-3. Conclusion The change from ICHD-3β to ICHD-3 resulted in few differences in the diagnoses of CH and PCH.

Haemochromatosis Gene (HFE) Polymorphisms and Migraine: An Association Study

Cephalalgia ◽  
2007 ◽  
Vol 27 (1) ◽  
pp. 9-13 ◽  
Author(s):  
I Rainero ◽  
E Rubino ◽  
C Rivoiro ◽  
W Valfrè ◽  
E Binello ◽  
...  
Keyword(s):  
Association Study ◽  
Clinical Features ◽  
Iron Metabolism ◽  
Genetic Factor ◽  
Disease Gene ◽  
Age At Onset ◽  
Control Design ◽  
Case Control ◽  
Allele Frequencies ◽  
Hfe Gene

Several studies have suggested that iron metabolism may be involved in the pathogenesis of migraine. Using a case-control design, we performed an association study in a cohort of Italian migraine patients to evaluate whether a particular allele or genotype of the haemochromatosis gene ( HFE) would modify the occurrence and clinical features of the disease. We genotyped 256 migraine patients and 237 healthy age-, sex- and ethnicity-matched controls for the C282Y and H63D polymorphisms of the HFE gene. Phenotype and allele frequencies of both polymorphisms were similarly distributed in migraine patients and controls. The patients carrying the DD genotype of the H63D polymorphism showed a later age at onset of the disease and an increased number of migraine attacks. Our data suggest that the HFE gene is not a major disease gene for migraine. However, the H63D polymorphism of the HFE gene may be considered a modifying genetic factor in migraine.

scholarly journals Association Study of Puberty-Related Candidate Genes in Chinese Female Population

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Gideon Omariba ◽  
Junhua Xiao
Keyword(s):  
Next Generation Sequencing ◽  
Association Study ◽  
Candidate Genes ◽  
Genetic Factors ◽  
Transition Period ◽  
Female Population ◽  
Number Of Genes ◽  
Puberty Onset ◽  
Next Generation Sequencing Ngs ◽  
Generation Sequencing

Puberty is a transition period where a child transforms to an adult. Puberty can be affected by various genetic factors and environmental influences. In mammals, the regulation of puberty is enhanced by the hypothalamic-pituitary-gonadal axis (HPG axis). A number of genes such as GnRH, Kiss1, and GPR54 have been reported as key regulators of puberty onset. In this study, we have conducted an association study of puberty-related candidate genes in Chinese female population. Gene variations reported to be related with some traits in a population may not exist in others due to different genetic and ethnic backgrounds, hence the need for this kind of study. The genotyping of SNPs was based on multiplex PCR and the next-generation sequencing (NGS) platform of Illumina. We finally performed association study using PLINK software. Our results confirmed that SNPs rs34787247 in LIN28, rs74795793 and rs9347389 in OCT-1, and rs379202 and rs10491080 in ZEB1 genes showed a significant association with puberty. With the result, it is reasonable to conclude that these genes affect the process of puberty in Shanghai Chinese female population, yet the mechanism remains to be investigated by further study.

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