Effect of age at thyroid stimulating hormone normalization on postural control in children with congenital hypothyroidism

AbstractObjectivesPrevalence of Maternal and congenital hypothyroidism is on the rise. To present the thyroid stimulating hormone screening results in babies born to hypothyroid mothers and assess the burden, aetiology of hypothyroidism in these babiesMethodsAll antenatal mothers attending our hospital during the study period were enrolled into the study. Group I includes 249 term babies born to hypothyroid mothers and group II comprises 2154 newborns born to mothers who are euthyroid. Heel prick thyroid stimulating hormone was done for all newborns on day 3 for both groups. Confirmatory venous testing was done for all for babies in group I and screen positives belonging to group II. Evaluation and therapy done as per standard guidelines.ResultsThyroid stimulating hormone values in the two groups are presented. There was significant correlation between peak maternal thyroid stimulating hormone and neonatal day 3 heel prick in group I (r=0.7, P<0.05). The prevalence of positive screening test in groups I and II was 3.8 and 1.03% (p<0.05) whereas corresponding values for confirmed disease was 4.3 and 0.6%, respectively (p<0.05). Aetiological evaluation revealed both transient hypothyroidism (33.3%) and permanent hypothyroidism (66.6%).Conclusion4.3% of babies born to hypothyroid mothers develop congenital hypothyroidism; aetiology being both transient and permanent. A venous test by 3 weeks is helpful in these babies to improve case identification.

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Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China

Global Pediatric Health ◽

10.1177/2333794x14567193 ◽

2015 ◽

Vol 2 ◽

pp. 2333794X1456719 ◽

Cited By ~ 3

Author(s):

Xin Fan ◽

Shaoke Chen ◽

Jiale Qian ◽

Suren Sooranna ◽

Jingi Luo ◽

...

Keyword(s):

Newborn Screening ◽

Congenital Hypothyroidism ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

Who Guidelines ◽

Newborn Screening Program ◽

Study Results ◽

Stimulating Hormone

Background. A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods. During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results. A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions. The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.

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Maternal education and newborn thyroid-stimulating hormone level in a congenital hypothyroidism screening program

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2018.1559809 ◽

2019 ◽

Vol 33 (16) ◽

pp. 2730-2734

Author(s):

Junhong Leng ◽

Ping Shao ◽

Shuang Zhang ◽

Nan Li ◽

Lei Pan ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Maternal Education ◽

Hormone Level ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Primary Thyroid Stimulating Hormone Screening for Congenital Hypothyroidism in King Abdullah Hospital, Bisha, Saudi Arabia

Cureus ◽

10.7759/cureus.7166 ◽

2020 ◽

Cited By ~ 1

Author(s):

Mohammed Abbas ◽

Eltayeb Tayrab ◽

Abedelmonium Elmakki ◽

Jowayria Tayrab ◽

Abdullah Al-shahrani ◽

...

Keyword(s):

Saudi Arabia ◽

Congenital Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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Screening for Hypothyroidism

PEDIATRICS ◽

10.1542/peds.72.2.263 ◽

1983 ◽

Vol 72 (2) ◽

pp. 263-264

Author(s):

Howard W. Kilbride ◽

Robert J. Lull ◽

Heinz G. Lehman

Keyword(s):

New England ◽

Congenital Hypothyroidism ◽

Human Error ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

The Past ◽

Cause Of Failure ◽

Stimulating Hormone

Although the New England Regional Screening Program report1 indicates that human error is the most likely cause of failure to detect congenital hypothyroidism in infants, our experience suggests that compensated hypothyroidism might be missed in some newborns unless screening includes a thyroid-stimulating hormone (TSH) assay and a thyroxine (T4) concentration. In the past 2 years, we have diagnosed congenital hypothyroidism in three infants. In at least one of these infants, the disease would not have been identified by T4 concentration screening alone.

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