Maternal education and newborn thyroid-stimulating hormone level in a congenital hypothyroidism screening program

Background. A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods. During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results. A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions. The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.

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Screening for Hypothyroidism

PEDIATRICS ◽

10.1542/peds.72.2.263 ◽

1983 ◽

Vol 72 (2) ◽

pp. 263-264

Author(s):

Howard W. Kilbride ◽

Robert J. Lull ◽

Heinz G. Lehman

Keyword(s):

New England ◽

Congenital Hypothyroidism ◽

Human Error ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

The Past ◽

Cause Of Failure ◽

Stimulating Hormone

Although the New England Regional Screening Program report1 indicates that human error is the most likely cause of failure to detect congenital hypothyroidism in infants, our experience suggests that compensated hypothyroidism might be missed in some newborns unless screening includes a thyroid-stimulating hormone (TSH) assay and a thyroxine (T4) concentration. In the past 2 years, we have diagnosed congenital hypothyroidism in three infants. In at least one of these infants, the disease would not have been identified by T4 concentration screening alone.

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Neonatal Thyroid-Stimulating Hormone Screening as an Indirect Method for the Assessment of Iodine Status in Central Siberia

International Journal of Diabetes & Metabolic Disorders ◽

10.33140/ijdmd/03/04/00003 ◽

2018 ◽

Vol 3 (4) ◽

Keyword(s):

Newborn Screening ◽

Congenital Hypothyroidism ◽

Iodine Deficiency ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

The Arctic ◽

Central Siberia ◽

Iodine Status ◽

The Republic ◽

Stimulating Hormone

Background: Iodine deficiency is associated with goiter and impaired brain function. Neonatal thyroid-stimulating hormone (TSH) screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and of its control. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mIU/L in newborn screening corresponds to the impaired iodine status of the population. The aim: to estimate the iodine deficiency and the effectiveness of iodine prophylaxis in Krasnoyarsk territory, Republics of Tuva and Khakassia according the results of neonatal TSH_screening. Methods: An 18-year analysis was performed in 34,980 newborns participating in the national thyroid newborn screening program. The TSH concentration was measured in dry blood spots collected by heel stick on filter paper, 96 hours after birth, using DELFIA method. Results: According to the data of the congenital hypothyroidism screening the rate of TSH < 5 mU/1 was 11.8% in Krasnoyarsk territory (23.9% in 2000) and corresponded to mild iodine deficiency. In different regions of Krasnoyarsk territory the rate of TSH < 5 mU/1 in the newborn varied from 3.5% to 23.7%. The highest values were marked in the Arctic peninsula Taimyr, in cities Zheleznogorsk (nuclear facility) and Sosnovoborsk, in Irbeysky, Suchobuzimsky, Eniseysky, Tuchtetsky, Novoselovsky regions (20.9–23.7%). In the Republic of Khakasia the rate of TSH < 5 mU/1 was 12.5%. In the Republic of Tyva the rate of TSH < 5 mU/1 was – 6.6% (38.6% in 1997; 11.5% in 2000). These results indicate mild iodine deficiency. Conclusion: Our investigations show mild iodine deficiency in Central Siberia demanding continuous adequate iodine prevention. Additional assessment of the iodine intake in the regions with mild iodine deficiency is needed to prevent suboptimal cognitive and psychomotor outcomes.

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An Optimal Capillary Screen Cut-off of Thyroid Stimulating Hormone for Diagnosing Congenital Hypothyroidism: Data from a Pilot Newborn Screening Program in Delhi

Indian Pediatrics ◽

10.1007/s13312-019-1515-5 ◽

2019 ◽

Vol 56 (4) ◽

pp. 281-286 ◽

Cited By ~ 2

Author(s):

Prashant Verma ◽

◽

Seema Kapoor ◽

Mani Kalaivani ◽

Pallavi Vats ◽

...

Keyword(s):

Newborn Screening ◽

Congenital Hypothyroidism ◽

Screening Program ◽

Thyroid Stimulating Hormone ◽

Newborn Screening Program ◽

Stimulating Hormone

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Serum thyroid stimulating hormone level for predicting utility of thyroid uptake and scan

Endocrine Research ◽

10.1080/07435800.2020.1810064 ◽

2020 ◽

pp. 1-4

Author(s):

Lauren Buehler ◽

Alireza Movahed ◽

Keren Zhou ◽

M. Cecilia Lansang

Keyword(s):

Hormone Level ◽

Thyroid Stimulating Hormone ◽

Thyroid Uptake ◽

Stimulating Hormone

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Impact of maternal thyroid disease on neonatal thyroid status

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0349 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Lakshmi Venugopalan ◽

Aishwarya Rajan ◽

Hemchand. K. Prasad ◽

Anupama Sankaran ◽

Gnanabalan Murugesan ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Study Group ◽

Thyroid Status ◽

Case Identification ◽

Group I ◽

Group Ii ◽

Maternal Thyroid ◽

Heel Prick ◽

Stimulating Hormone

AbstractObjectivesPrevalence of Maternal and congenital hypothyroidism is on the rise. To present the thyroid stimulating hormone screening results in babies born to hypothyroid mothers and assess the burden, aetiology of hypothyroidism in these babiesMethodsAll antenatal mothers attending our hospital during the study period were enrolled into the study. Group I includes 249 term babies born to hypothyroid mothers and group II comprises 2154 newborns born to mothers who are euthyroid. Heel prick thyroid stimulating hormone was done for all newborns on day 3 for both groups. Confirmatory venous testing was done for all for babies in group I and screen positives belonging to group II. Evaluation and therapy done as per standard guidelines.ResultsThyroid stimulating hormone values in the two groups are presented. There was significant correlation between peak maternal thyroid stimulating hormone and neonatal day 3 heel prick in group I (r=0.7, P<0.05). The prevalence of positive screening test in groups I and II was 3.8 and 1.03% (p<0.05) whereas corresponding values for confirmed disease was 4.3 and 0.6%, respectively (p<0.05). Aetiological evaluation revealed both transient hypothyroidism (33.3%) and permanent hypothyroidism (66.6%).Conclusion4.3% of babies born to hypothyroid mothers develop congenital hypothyroidism; aetiology being both transient and permanent. A venous test by 3 weeks is helpful in these babies to improve case identification.

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Approach to Subclinical Thyroid Diseas

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v26i2.4187 ◽

1970 ◽

Vol 26 (2) ◽

pp. 91-96

Author(s):

Satya Ranjan Sutradhar

Keyword(s):

Subclinical Hypothyroidism ◽

Thyroid Dysfunction ◽

Hormone Level ◽

Elevated Serum ◽

Thyroid Stimulating Hormone ◽

Good Evidence ◽

Reference Ranges ◽

Mineral Density ◽

Asymptomatic Patients ◽

Stimulating Hormone

Subclinical thyroid dysfunction is defined as an abnormal serum thyroid-stimulating hormone level and free thyroxine and triiodothyronine levels within their reference ranges. The prevalence of subclinical hyperthyroidism is about 2 percent. Subclinical hypothyroidism is found in approximately 4 to 8.5 percent of the population. Most national organizations recommend against routine screening of asymptomatic patients, but screening is recommended for high risk populations. The management of subclinical thyroid dysfunction is controversial. There is good evidence that subclinical hypothyroidism is associated with progression to overt disease. Patients with a serum thyroid-stimulating hormone level greater than 10 mIU/L have a higher incidence of elevated serum low density lipoprotein cholesterol concentrations; however, evidence is lacking for other associations. There is insufficient evidence that treatment of subclinical hypothyroidism is beneficial. A serum thyroid stimulating hormone level of less than 0.1 mIU/L is associated with progression to overt hyperthyroidism, atrial fibrillation, reduced bone mineral density, and cardiac dysfunction. There is little evidence that early treatment alters the clinical course. DOI: 10.3329/jbcps.v26i2.4187 J Bangladesh Coll Phys Surg 2008; 26: 91-96

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Primary Thyroid Stimulating Hormone Screening for Congenital Hypothyroidism in King Abdullah Hospital, Bisha, Saudi Arabia

Cureus ◽

10.7759/cureus.7166 ◽

2020 ◽

Cited By ~ 1

Author(s):

Mohammed Abbas ◽

Eltayeb Tayrab ◽

Abedelmonium Elmakki ◽

Jowayria Tayrab ◽

Abdullah Al-shahrani ◽

...

Keyword(s):

Saudi Arabia ◽

Congenital Hypothyroidism ◽

Thyroid Stimulating Hormone ◽

Stimulating Hormone

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A STUDY ON RELATION OF THYROID STIMULATING HORMONE LEVEL WITH SKELETAL METASTASIS IN CARCINOMA PROSTATE PATIENTS

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/1219 ◽

2017 ◽

Vol 6 (79) ◽

pp. 5619-5625

Author(s):

Minaxi Sharma ◽

Krishna Gopal Sharma ◽

Deepak Sethi ◽

Rajveer Singh ◽

Anjali Sethi

Keyword(s):

Hormone Level ◽

Skeletal Metastasis ◽

Thyroid Stimulating Hormone ◽

Carcinoma Prostate ◽

Stimulating Hormone

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Screening for Congenital Hypothyroidism With Specimen Collection at Two Time Periods: Results of the Northwest Regional Screening Program

PEDIATRICS ◽

10.1542/peds.76.5.734 ◽

1985 ◽

Vol 76 (5) ◽

pp. 734-740

Author(s):

Stephen H. LaFranchi ◽

Cheryl E. Hanna ◽

Patricia L. Krainz ◽

Michael R. Skeels ◽

Richard S. Miyahira ◽

...

Keyword(s):

Congenital Hypothyroidism ◽

Filter Paper ◽

Age Of Onset ◽

Screening Program ◽

Thyroid Tissue ◽

Cost Effective ◽

Thyroid Stimulating Hormone ◽

Primary Hypothyroidism ◽

Skeletal Maturation ◽

Second Screen

To determine the benefit of collecting two routine specimens to test for congenital hypothyroidism, we examined the results of our newborn screening program during the last 9.5 years. The Northwest Regional Screening Program (NWRSP) performs a primary thyroxine test with thyroid-stimulating hormone determinations on the lowest 10% of dried blood filter paper specimens. An initial specimen is obtained in the newborn period, and a routine second specimen is collected at approximately 4 to 6 weeks of age in all infants born in Oregon and 25% of infants born in Idaho, Montana, Alaska, and Nevada. Between May 1975 and October 1984, 182 infants with primary hypothyroidism were detected from 811,917 infants screened, a prevalence rate of 1:4,461. The routine second specimen led to the diagnosis of 19 infants of 484,604 infants screened, a detection rate of 1:25,505. When infants detected by the second screen were compared with those detected by the first screen, they had higher thyroxine and lower thyroidstimulating hormone concentrations on filter paper and serum specimens. When thyroid scanning was used, all but one infant detected by the second screen had some residual thyroid tissue, whereas 35% of infants detected by the first screen had thyroid aplasia. Skeletal maturation was more likely to be normal in infants detected by the second screen. These infants appear to have milder hypothyroidism due to a later age of onset or slower evolution of thyroid failure. At a cost of $31,881 per infant detected by the second screen, the NWRSP found it cost-effective to obtain a routine second specimen.

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