GLYCEROL PHOSPHATE DEHYDROGENASE ACTIVITY OF DEVELOPING RAT CENTRAL NERVOUS SYSTEM

The central nervous system is one of the primary target organs for hydrogen sulphide (H2S) toxicity; however, there are limited data on the neurotoxic effects of low-dose chronic exposure on the developing nervous system. Levels of serotonin and norepinephrine in the developing rat cerebellum and frontal cortex were determined following chronic exposure to 20 and 75 ppm H2S during perinatal development. Both monoamines were altered in rats exposed to 75 ppm H2S compared with controls; serotonin levels were significantly increased at days 14 and 21 postnatal in both brain regions, and norepinephrine levels were significantly increased at days 7, 14, and 21 postnatal in cerebellum and at day 21 in the frontal cortex. Exposure to 20 ppm H2S significantly increased the levels of serotonin in the frontal cortex at day 21, whereas levels of norepinephrine were significantly reduced in the frontal cortex at days 14 and 21, and at day 14 in the cerebellum.Key words: hydrogen sulphide, monoamines, serotonin, norepinephrine, neurotoxicity.

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Neurotoxicity ofN-methyl-d-aspartate is markedly enhanced in developing rat central nervous system

Brain Research ◽

10.1016/0006-8993(88)90306-x ◽

1988 ◽

Vol 459 (1) ◽

pp. 200-203 ◽

Cited By ~ 368

Author(s):

John W. McDonald ◽

Faye S. Silverstein ◽

Michael V. Johnston

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Developing Rat

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The Effect of Acute Cadmium Exposure on the Vascular Endothelial Barrier Antigen and Astrocyte Morphology in the Developing Rat Central Nervous System

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.lb371 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Michael O Ibiwoye ◽

Qiana Matthews ◽

Pamela McElroy ◽

James D Foster

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Cadmium Exposure ◽

Endothelial Barrier ◽

Vascular Endothelial ◽

Endothelial Barrier Antigen ◽

Developing Rat

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CEREBROSPINAL FLUID LDH IN 287 CHILDREN, INCLUDING 53 CASES OF MENINGITIS OF BACTERIAL AND NON-BACTERIAL ETIOLOGY

PEDIATRICS ◽

10.1542/peds.41.6.1097 ◽

1968 ◽

Vol 41 (6) ◽

pp. 1097-1103

Author(s):

William Neches ◽

Martin Platt

Keyword(s):

Central Nervous System ◽

Cerebrospinal Fluid ◽

Nervous System ◽

Dehydrogenase Activity ◽

Newborn Infants ◽

Central Nervous System Disease ◽

Lactic Dehydrogenase ◽

Spinal Fluid ◽

Initial Examination ◽

System Disease

Cerebrospinal fluid lactic dehydrogenase activity was determined in 287 children. Among these, 87 had no central nervous system disease and were considered to be controls. Mean lactic dehydrogenase activity in 69 controls (excluding newborn infants) was 14 units. In 18 control infants less than 1 week of age, the mean lactic dehydrogenase activity was 50 units. Thirty-two patients with bacterial meningitis had a mean cerebrospinal fluid lactic dehydrogenase of 251 units on the initial examination; 20 patients with aseptic meningoencephalitis had a mean lactic dehydrogenase activity of 23 units. The difference between the lactic dehydrogenase activity in children with bacterial and aseptic meningitis was highly significant (p < 0.005). The clinical course of the patients studied was reflected by the change in cerebrospinal fluid lactic dehydrogenase activity on serial determinations. Spinal fluid isoenzyme patterns were studied in a few patients with bacterial and non-bacterial central nervous system disorders. This study indicates that the determination of lactic dehydrogenase in spinal fluid is a useful adjunct to other cerebrospinal fluid parameters in the differential diagnosis of central nervous system infections.

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