Inhibition of apoptosis-inducing factor translocation is involved in protective effects of hepatocyte growth factor against excitotoxic cell death in cultured hippocampal neurons

2005 ◽  
Vol 95 (5) ◽  
pp. 1277-1286 ◽  
Author(s):  
Naoko Ishihara ◽  
Norio Takagi ◽  
Makiko Niimura ◽  
Keiko Takagi ◽  
Midori Nakano ◽  
...  
Keyword(s):  
Cell Death ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hippocampal Neurons ◽  
Protective Effects ◽  
Apoptosis Inducing Factor ◽  
Excitotoxic Cell Death ◽  
Hepatocyte Growth ◽  
Cultured Hippocampal Neurons

scholarly journals Protection of Hippocampal Neurons from Ischemia-Induced Delayed Neuronal Death by Hepatocyte Growth Factor: A Novel Neurotrophic Factor

1998 ◽  
Vol 18 (4) ◽  
pp. 345-348 ◽  
Author(s):  
Takahito Miyazawa ◽  
Kunio Matsumoto ◽  
Hidenori Ohmichi ◽  
Hiroshi Katoh ◽  
Tetsumori Yamashima ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Neurotrophic Factor ◽  
Neuronal Death ◽  
Hippocampal Neurons ◽  
Neuronal Damage ◽  
Delayed Neuronal Death ◽  
Mongolian Gerbils ◽  
Hepatocyte Growth ◽  
Neuroprotective Action

Hepatocyte growth factor (HGF), a natural ligand for the c-met protooncogene product, exhibits mitogenic, motogenic, and morphogenic activities for regeneration of the liver, kidney, and lung. Recently, HGF was clearly shown to enhance neurite outgrowth in vitro. To determine whether HGF has a neuroprotective action against the death of neurons in vivo, we studied the effect of HGF on delayed neuronal death in the hippocampus after 5-minute transient forebrain ischemia in Mongolian gerbils. Continuous postischemic intrastriatal administration of human recombinant HGF (10 or 30 μg) for 7 days potently prevented the delayed death of hippocampal neurons under both anesthetized and awake conditions. Even when HGF infusion started 6 hours after ischemia (i.e., in a delayed manner), HGF exhibited a neuroprotective action. We conclude that HGF, a novel neurotrophic factor, has a profound neuroprotective effect against postischemic delayed neuronal death in the hippocampus, which may have implications for the development of new therapeutic strategies for ischemic neuronal damage in humans.

Recombinant human hepatocyte growth factor provides protective effects in cerulein‐induced acute pancreatitis in mice

2018 ◽  
Vol 233 (12) ◽  
pp. 9354-9364 ◽  
Author(s):  
Mayrel Palestino‐Dominguez ◽  
Mario Pelaez‐Luna ◽  
Roberto Lazzarini‐Lechuga ◽  
Ignacio Rodriguez‐Ochoa ◽  
Veronica Souza ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Human Hepatocyte ◽  
Protective Effects ◽  
Human Hepatocyte Growth Factor ◽  
Hepatocyte Growth

Hepatocyte growth factor (HGF/SF) is a muscle-derived survival factor for a subpopulation of embryonic motoneurons

Development ◽  
1997 ◽  
Vol 124 (15) ◽  
pp. 2903-2913 ◽  
Author(s):  
Y. Yamamoto ◽  
J. Livet ◽  
R.A. Pollock ◽  
A. Garces ◽  
V. Arce ◽  
...  
Keyword(s):  
Cell Death ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Muscle Development ◽  
Neurotrophic Activity ◽  
Survival Factor ◽  
Trophic Activity ◽  
Blocking Antibodies ◽  
Hepatocyte Growth ◽  
Motoneuron Cell

Muscle-derived factors are known to be important for the survival of developing spinal motoneurons, but the molecules involved have not been characterized. Hepatocyte growth factor/scatter factor (HGF/SF) plays an important role in muscle development and motoneuron axon outgrowth. We show that HGF/SF has potent neurotrophic activity (EC50=2 pM) for a subpopulation (40%) of purified embryonic rat motoneurons. Moreover, HGF/SF is an essential component of muscle-derived support for motoneurons, since blocking antibodies to HGF/SF specifically inhibited 65% of the trophic activity of media conditioned by C2/C7 skeletal myotubes, but did not inhibit the trophic activity secreted by Schwann cell lines. High levels of expression of the HGF/SF receptor c-Met in the spinal cord are restricted to subsets of motoneurons, mainly in limb-innervating segments. Consistent with this distribution, cultured motoneurons from limb-innervating brachial and lumbar segments showed a more potent response to HGF/SF than did thoracic motoneurons. By the end of the period of motoneuron cell death, levels of c-Met mRNA in motoneurons were markedly reduced, suggesting that the effects of HGF/SF may be limited to the period of motoneuron cell death. HGF/SF may play an important role during motoneuron development as a muscle-derived survival factor for a subpopulation of limb-innervating motoneurons.

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