scholarly journals The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies

2008 ◽  
Vol 107 (5) ◽  
pp. 1358-1368 ◽  
Author(s):  
Birk Poller ◽  
Heike Gutmann ◽  
Stephan Krähenbühl ◽  
Babette Weksler ◽  
Ignacio Romero ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Human Brain ◽  
Cell Line ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Drug Transport ◽  
Brain Endothelial Cell ◽  
Transport Studies ◽  
Blood Brain Barrier Model ◽  
Barrier Model

scholarly journals Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

2009 ◽  
Vol 8 (11) ◽  
pp. 1803-1807 ◽  
Author(s):  
Kiem Vu ◽  
Babette Weksler ◽  
Ignacio Romero ◽  
Pierre-Olivier Couraud ◽  
Angie Gelli
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endothelial Cell ◽  
Human Brain ◽  
Cell Line ◽  
Blood Brain Barrier ◽  
Central Nervous System Infection ◽  
Brain Barrier ◽  
Brain Endothelial Cell ◽  
Blood Brain

ABSTRACT Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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