Challenge-induced plasma exudation and mucinous secretion in human airways

2005 ◽  
Vol 25 (4) ◽  
pp. 241-245 ◽  
Author(s):  
Lennart Greiff ◽  
Morgan Andersson ◽  
William B. Coman ◽  
Henrik Lindberg ◽  
Gyorgy Marko-Varga ◽  
...  
1989 ◽  
Vol 66 (1) ◽  
pp. 268-272 ◽  
Author(s):  
M. G. Belvisi ◽  
D. F. Rogers ◽  
P. J. Barnes

Opioid drugs have been shown to inhibit neurogenic plasma exudation in skin by a presynaptic mechanism. We determined whether a similar inhibitory effect operates in the airways of anesthetized guinea pigs in vivo with the use of Evans blue dye as a marker of plasma leakage. Stimulation of the vagus nerve significantly increased leakage of dye in trachea and main bronchi (by approximately 300 and 600%, respectively). Similar increases in leakage were seen in the presence of atropine and propranolol. Morphine (1–30 mg/kg iv) inhibited leakage in a dose-related manner with complete inhibition in the trachea at a dose of 30 mg/kg. The inhibition was blocked by the opioid receptor-antagonist naloxone (1 mg/kg iv). Intravenous substance P significantly increased leakage but was not inhibited by morphine. We conclude that morphine inhibits neurogenic plasma leakage by presynaptic inhibition of release of neuropeptides from sensory nerve endings. If similar mechanisms are operative in human airways, inhibition of neurogenic plasma leakage by opioid drugs devoid of central effects may be of value in the therapy of asthma.


Allergy ◽  
1995 ◽  
Vol 50 (7) ◽  
pp. 593-597 ◽  
Author(s):  
L. Greiff ◽  
M. Andersson ◽  
C. Svensson ◽  
M. Nilsson ◽  
I. Erjefält ◽  
...  

Author(s):  
Digamber Singh

The human respiratory tract has a complex airflow pattern. If any obstruction is present in the airways, it will change the airflow pattern and deposit particles inside the airways. This is the concern of breath quality (inspired air), and it is decreasing due to the unplanned production of material goods. This is a primary cause of respiratory illness (asthma, cancer, etc.). Therefore, it is important to identify the flow characteristics in the human airways and airways with a glomus tumour with particle deposition. A numerical diagnosis is presented with an asymmetric unsteady-state light breathing condition (10 l/min). An in vitro human respiratory tract model has been reconstructed using computed tomography scan techniques and an artificial glomus tumour developed 2 cm above a carina on the posterior wall of the trachea. The transient flow characteristics are numerically simulated with a realizable (low Reynolds number) k–ɛ turbulence model. The flow disturbance is captured around the tumour, which influenced the upstream and downstream of the flow. The flow velocity pattern, wall shear stress and probable area of inflammation (hotspot) due to suspended particle deposition are determined, which may assist doctors more effectively in aerosol therapy and prosthetics of human airways illness.


1983 ◽  
Vol 14 (3) ◽  
pp. 184-186 ◽  
Author(s):  
C. Melandri ◽  
G. Tarroni ◽  
V. Prodi ◽  
T.De Zaiacomo ◽  
M. Formignani ◽  
...  

1991 ◽  
Vol 203 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Roberto Jongejan ◽  
Johan De Jongste ◽  
Rolien Raatgeep ◽  
Theo Stijnen ◽  
Ivan Bonta ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document