Lymphadenectomy in the staging and treatment of intrahepatic cholangiocarcinoma: a population-based study using the National Cancer Institute SEER database

Objective. To characterize the disease progression and median survival of patients with prostate cancer (PCa) according to the prostatic-specific acid phosphatase (PAP) analysis in a population-based study from the Surveillance, Epidemiology, and End Results (SEER) database.Materials and Methods. Prostate cancer patients with completed PAP results were identified using the SEER database of the National Cancer Institute. The Mann-Whitney Sum test was utilized to compare the statistical significance for measurement data and ranked data. Data were stratified by ages, races, TNM Classification of Malignant Tumors (TNM), pathological grades, number of tumors, PAP, and survival duration. Multivariable logistic analysis was performed to identify predictors of the presence of invasion and metastases. Cox regression was analyzed for the factors associated with all-cause mortality and prostate cancer-specific mortality. Moreover, survival curve was used to detect the survival months. The unknown data were excluded from these tests.Results. In total, there are 5184 PAP+ patients and 3161 PAP- patients involved. The Mann-Whitney Sum test showed that slightly greater tumor size (P=0.03), elevated lymphatic (P=0.005) and distant (P<0.001) metastasis rate, higher pathological grade (P<0.001), localized tumor number (P<0.001), and shortened survival months (P<0.001) were observed in the PAP+ group compared with the PAP- group. In the multivariable logistic regression, invasion and metastasis Hazard Ratio (HR) were elevated significantly (P<0.001) in the PAP+ individuals. In the survival analysis, PAP- patients experienced the prolonged median survival. In the postsurgical patients, the survival months were still longer in PAP+ patients compared with the negative ones (P<0.001), though surgery prolonged the survival months of both groups. Survival months stratified by localized, invasion, and metastasis situations were analyzed. In the three stratified subgroups, the survival duration is significantly decreased in the PAP+ individuals in the localized PCa group (P<0.001) and the metastasis group (P=0.013).Conclusions. The findings of this study provide population-based estimates of the PCa progress and prognosis for patients with different PAP results, which may suggest a renewed period for the PAP.

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Acinar Cell Carcinoma of Pancreas: A Population Based Study of 253 Patients Using SEER Database (1973 - 2008)

Journal of Surgical Research ◽

10.1016/j.jss.2012.10.228 ◽

2013 ◽

Vol 179 (2) ◽

pp. 194

Author(s):

S. Patil ◽

R.S. Chamberlain

Keyword(s):

Cell Carcinoma ◽

Acinar Cell ◽

Acinar Cell Carcinoma ◽

Population Based ◽

Seer Database ◽

Population Based Study ◽

Carcinoma Of Pancreas

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Conditional Survival After Surgical Resection of Appendiceal Tumors: a Population-based Study

10.21203/rs.3.rs-403708/v1 ◽

2021 ◽

Author(s):

Shutao Zhao ◽

Chang Lu ◽

Junan Li ◽

Chao Zhang ◽

Xudong Wang

Keyword(s):

Prognostic Factors ◽

Cox Regression ◽

Population Based ◽

Conditional Survival ◽

Seer Database ◽

Cancer Specific Survival ◽

Population Based Study ◽

Factors Affecting ◽

Probability Of Survival ◽

N Stage

Abstract Background: This study aimed to evaluate the conditional survival (CS) of appendiceal tumors (ATs) after surgery.Methods: A total of 3,031 patients with ATs who underwent surgery were included in the Surveillance Epidemiology and End Results (SEER) database from 2004 to 2016. A multivariate Cox regression model was used to analyze the prognostic factors affecting overall survival (OS) and cancer-specific survival (CSS). CS was used to calculate the probability of survival for another 3 years after the patient had survived x years. The formulas were COS3 = OS (x + 3) /OS (x), and CCS3 = CSS (x + 3)/CSS (x).Results: The 1-year, 3-year, and 5-year OSs for all patients were 95.6%, 83.3%, and 73.9%, respectively, while the 1-year, 3-year, and 5-year CSSs were 97.0%, 87.1%, and 79.9%, respectively. Age, grade, histology, N stage, carcinoembryonic antigen (CEA), and radiation were independent prognostic factors for OS and CSS. For patients that survived for 1 year, 3 years, and 5 years, their COS3s were 81.7%, 83.9%, and 87.0%, respectively. The CCS3s were 85.5%, 88.3%, and 92.0% respectively. In patients with poor clinicopathological factors, COS3 and CCS3 increased significantly, and the survival gap between OS and COS3, CSS and CCS3 was more obvious.Conclusions: CS for appendiceal tumors were dynamic and increased over time, especially in patients with poor prognosis.

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