Clinical significance of elevated serum levels of matrix metalloproteinase-3 and C-reactive protein in patients with rheumatoid arthritis

2007 ◽  
Vol 10 (4) ◽  
pp. 295-299 ◽  
Author(s):  
Hayato NAGASAWA ◽  
Hideto KAMEDA ◽  
Koichi AMANO ◽  
Tsutomu TAKEUCHI
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Clinical Significance ◽  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein

scholarly journals Elevated Serum Levels of Resistin, Leptin, and Adiponectin are Associated with C-reactive Protein and also Other Clinical Conditions in Rheumatoid Arthritis

2011 ◽  
Vol 50 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Takumi Yoshino ◽  
Natsuko Kusunoki ◽  
Nahoko Tanaka ◽  
Kaichi Kaneko ◽  
Yoshie Kusunoki ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Elevated Serum ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Clinical Conditions

Serum Levels of Matrix Metalloproteinase 3 (Stromelysin 1) for Monitoring Synovitis in Rheumatoid Arthritis

2007 ◽  
Vol 131 (4) ◽  
pp. 563-570
Author(s):  
Ari Kobayashi ◽  
Satoko Naito ◽  
Hiroyuki Enomoto ◽  
Takayuki Shiomoi ◽  
Tokuhiro Kimura ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
White Blood Cells ◽  
Serum Levels ◽  
Cartilage Destruction ◽  
Serum Samples ◽  
Tissue Samples ◽  
Matrix Metalloproteinase 3 ◽  
Reactive Protein ◽  
Synovial Tissues

Abstract Context.—Matrix metalloproteinase 3 (MMP-3) is expressed in synovial tissues and involved in cartilage destruction in rheumatoid arthritis and osteoarthritis. Objective.—To study whether measurement of MMP-3 serum concentrations is useful to monitor the activity of rheumatoid synovitis. Design.—Levels of MMP-3 in serum and synovial tissue samples obtained from 29 rheumatoid arthritis patients and 20 osteoarthritis patients were measured by the 1-step sandwich enzyme immunoassay system. Results.—Levels of MMP-3 in the serum and synovial samples were significantly higher in rheumatoid arthritis than in osteoarthritis (P < .001), and the levels correlated directly with each other (r = 0.712, P < .001; N = 49). Immunohistochemistry demonstrated almost exclusive localization of MMP-3 to the lining cells in rheumatoid synovium. The immunoreactivity correlated directly with the scores of synovial inflammatory cell infiltration (r = 0.606, P < .001; n = 29) and the MMP-3 levels in the synovial tissues (r = 0.564, P = .001; n = 29) and those in the serum samples (r = 0.529, P = .003; n = 29) in rheumatoid arthritis. Levels of MMP-3 in rheumatoid serum samples dropped to low values at 1 and 2 weeks after total knee arthroplasty, while the levels of C-reactive protein increased at 1 week and the erythrocyte sedimentation rate and counts of white blood cells and platelets were unchanged at 1 and 2 weeks postoperative. Conclusions.—Our results demonstrate that MMP-3 levels in the serum of rheumatoid arthritis patients correlate with the levels produced by the synovial lining cells and suggest that the activity of rheumatoid synovitis can be monitored by measuring serum levels of MMP-3.

scholarly journals Clinical significance of serum matrix metalloproteinase-3 level in patients with rheumatoid arthritis

Ensho Saisei ◽  
2005 ◽  
Vol 25 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Hayato Nagasawa ◽  
Hideto Kameda ◽  
Koichi Amano ◽  
Tsutomu Takeuchi
Keyword(s):  
Rheumatoid Arthritis ◽  
Matrix Metalloproteinase ◽  
Clinical Significance ◽  
Matrix Metalloproteinase 3

scholarly journals Expression of ICAM1 and VCAM1 Serum Levels in Rheumatoid Arthritis Clinical Activity. Association with Genetic Polymorphisms

2009 ◽  
Vol 26 (3) ◽  
pp. 119-126 ◽  
Author(s):  
Rosa Elena Navarro-Hernández ◽  
Edith Oregon-Romero ◽  
Mónica Vázquez-Del Mercado ◽  
Héctor Rangel-Villalobos ◽  
Claudia Azucena Palafox-Sánchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Status ◽  
Serum Levels ◽  
Clinical Activity ◽  
C Reactive Protein ◽  
Soluble Adhesion Molecules ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Pcr Rflp ◽  
Elisa Technique

To investigate the association of sICAM-1 and sVCAM-1 with ICAM1 721G>A and VCAM1 1238G>C polymorphisms and rheumatoid arthritis (RA) clinical activity, sixty RA patients and 60 healthy non-related subjects (HS) matched for age and sex were recruited. Soluble adhesion molecules were determined by ELISA technique. Rheumatoid factor (RF), C reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) were measured by routine methods. Disability and clinical activity was measured with Spanish-HAQ-DI and DAS28 scores, respectively. The ICAM1 and VCAM1 polymorphism were identified using the PCR-RFLP procedure. Inter-group comparison showed increased levels of sICAM-1 and sVCAM-1 in RA patients (284 and 481 ng/mL) versus HS (132 and 280 ng/mL); in the RA group, significant correlations between sVCAM-1 and RF (r= 0.402), ESR (r= 0.426), Spanish-HAQ-DI (r= 0.276), and DAS28 (r= 0.342) were found, whereas sICAM-1 only correlated with RF (r= 0.445). In RA patients, a significant association with the 721A allele of ICAM1 polymorphism (p= 0.04), was found. In addition, the allele impact (G/A+A/A) of this polymorphism was confirmed, (p= 0.038, OR = 2.3, C.I. 1.1–5.0). sVCAM-1 and sICAM-1 serum levels reflected the clinical status in RA, independently of the ICAM1 and VCAM1 polymorphism. However, the ICAM1 721A allele could be a genetic marker to RA susceptibility.

Biomarkers of Bone Metabolism in Ankylosing Spondylitis in Relation to Osteoproliferation and Osteoporosis

2014 ◽  
Vol 41 (7) ◽  
pp. 1349-1356 ◽  
Author(s):  
Eva Klingberg ◽  
Merja Nurkkala ◽  
Hans Carlsten ◽  
Helena Forsblad-d’Elia
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Bone Metabolism ◽  
Activity Index ◽  
Elevated Serum ◽  
Serum Levels ◽  
Spinal Mobility ◽  
C Reactive Protein ◽  
Mineral Density ◽  
Reactive Protein

Objective.To identify biomarkers for bone metabolism in patients with ankylosing spondylitis (AS) and to determine the relationship between these biomarkers and disease activity, back mobility, osteoproliferation, and bone mineral density (BMD).Methods.Serum levels of Wingless protein (Wnt-3a), Dickkopf-1 (DKK-1), sclerostin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), and osteoprotegerin were assessed using ELISA. Ankylosing Spondylitis Disease Activity Score-C reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis patient global score, and C-reactive protein (CRP) were used as disease activity measures, and Bath Ankylosing Spondylitis Metrology Index (BASMI) as a measure of spinal mobility. Lateral spine radiographs were scored for chronic AS-related changes (mSASSS). BMD was measured with dual-energy x-ray absorptiometry.Results.Two hundred four patients with AS (NY criteria; 57% men), with a mean age of 50 ± 13 years and disease duration 15 ± 11 years, and 80 age and sex-matched controls were included. The patients with AS had significantly higher serum levels of Wnt-3a (p < 0.001) and lower levels of sclerostin (p = 0.014) and sRANKL (p = 0.047) compared with the controls. High CRP was associated with low sclerostin (rS = −0.21, p = 0.003) and DKK-1 (rS = −0.14, p = 0.045). In multiple linear regression analyses, increasing BASMI and mSASSS were independently associated with older age, male sex, high CRP, and elevated serum levels of Wnt-3a. In addition, mSASSS remained associated with a high number of smoking pack-years after adjusting for age. Low BMD of femoral neck was associated with high mSASSS after adjusting for age.Conclusion.Serum levels of Wnt-3a are elevated in AS and associated with increased BASMI and mSASSS, independent of age, indicating that Wnt-3a could be a biomarker for the osteoproliferative process.

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