Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder

Objective.To identify biomarkers for bone metabolism in patients with ankylosing spondylitis (AS) and to determine the relationship between these biomarkers and disease activity, back mobility, osteoproliferation, and bone mineral density (BMD).Methods.Serum levels of Wingless protein (Wnt-3a), Dickkopf-1 (DKK-1), sclerostin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), and osteoprotegerin were assessed using ELISA. Ankylosing Spondylitis Disease Activity Score-C reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis patient global score, and C-reactive protein (CRP) were used as disease activity measures, and Bath Ankylosing Spondylitis Metrology Index (BASMI) as a measure of spinal mobility. Lateral spine radiographs were scored for chronic AS-related changes (mSASSS). BMD was measured with dual-energy x-ray absorptiometry.Results.Two hundred four patients with AS (NY criteria; 57% men), with a mean age of 50 ± 13 years and disease duration 15 ± 11 years, and 80 age and sex-matched controls were included. The patients with AS had significantly higher serum levels of Wnt-3a (p < 0.001) and lower levels of sclerostin (p = 0.014) and sRANKL (p = 0.047) compared with the controls. High CRP was associated with low sclerostin (rS = −0.21, p = 0.003) and DKK-1 (rS = −0.14, p = 0.045). In multiple linear regression analyses, increasing BASMI and mSASSS were independently associated with older age, male sex, high CRP, and elevated serum levels of Wnt-3a. In addition, mSASSS remained associated with a high number of smoking pack-years after adjusting for age. Low BMD of femoral neck was associated with high mSASSS after adjusting for age.Conclusion.Serum levels of Wnt-3a are elevated in AS and associated with increased BASMI and mSASSS, independent of age, indicating that Wnt-3a could be a biomarker for the osteoproliferative process.

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Prognostic and Predictive Value of Serum C-Reactive Protein Levels in Patients with Metastatic Or Locally Recurrent Gastric Cancer

The International Journal of Biological Markers ◽

10.5301/jbm.5000210 ◽

2016 ◽

Vol 31 (3) ◽

pp. 294-299 ◽

Cited By ~ 3

Author(s):

Zhigang Chen ◽

Yongchen Sun ◽

Ji Wang ◽

Xudong Shen ◽

Lei Chen ◽

...

Keyword(s):

Gastric Cancer ◽

Overall Survival ◽

Malignant Tumors ◽

Elevated Serum ◽

Roc Curves ◽

Serum Levels ◽

C Reactive Protein ◽

Term Survival ◽

Reactive Protein ◽

Serum Crp

Background and Aims Increasing evidence suggests that elevated serum levels of C-reactive protein (CRP) are associated with poor survival in many malignant tumors. However, the prognostic value of CRP in advanced gastric cancer (AGC) remains uncertain. This study was undertaken to evaluate the significance of serum CRP as a biomarker of long-term survival in patients with AGC. Methods The serum CRP levels of AGC patients were analyzed for clinicopathological significance. Data were collected retrospectively for 244 patients treated between October 1, 2006 and September 30, 2013. The prognostic effect of serum CRP levels was evaluated. Results The baseline CRP level before chemotherapy was significantly associated with overall survival. The median survival was 351 days for patients with CRP ≥10 mg/L and 370 days for patients with CRP c10 mg/L (p = 0.033). Cox analysis revealed CRP to be an independent prognostic factor for overall survival. In the 93 patients whose baseline CRP was ≥10 mg/L, a cutoff point of 22% for the CRP declining rate provided optimum sensitivity and specificity for 1-year survival based on ROC curves. A CRP declining rate >22% was found to predict longer overall survival (410 days versus 299 days; p = 0.001). Conclusions Elevated serum CRP baseline levels before chemotherapy were associated with reduced overall survival in patients with AGC. The CRP declining rate was also associated with overall survival. The CRP baseline concentration before chemotherapy and CRP declining rate after chemotherapy may be used as novel, widely available and real-time independent prognostic and predictive markers of AGC.

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Periodontitis is associated with elevated serum levels of cardiac biomarkers—Soluble ST2 and C‐reactive protein

Journal Of Clinical Periodontology ◽

10.1111/jcpe.13149 ◽

2019 ◽

Vol 46 (8) ◽

pp. 809-818 ◽

Cited By ~ 4

Author(s):

Kitti Torrungruang ◽

Dissayawadee Katudat ◽

Rangsini Mahanonda ◽

Piyamitr Sritara ◽

Artit Udomsak

Keyword(s):

Elevated Serum ◽

Serum Levels ◽

Cardiac Biomarkers ◽

C Reactive Protein ◽

Soluble St2 ◽

Reactive Protein

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C-reactive protein and parathyroid hormone in acute severe psychotic disorders (schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder)

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.2104 ◽

2017 ◽

Vol 41 (S1) ◽

pp. S185-S186

Author(s):

S. Arya ◽

H. Ahmadkhaniha ◽

K. Alavi ◽

B. Arya ◽

Z. Zarei

Keyword(s):

Bipolar Disorder ◽

Vitamin D ◽

Psychotic Disorder ◽

Psychotic Disorders ◽

Sun Exposure ◽

Serum Levels ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Calcium Phosphorus

Introductionand objectives Schizophrenia accompanies with elevated C-reactive protein (CRP) and vitamin D deficiency. However, there are scarce documentations regarding bipolar disorder and methamphetamine-induced psychotic disorder.AimTo compare serum levels of vitamin D, parathyroid hormone (PTH), calcium, phosphorus and CRP levels in psychotic disorder patients and control group.MethodsA case-control study was conducted on four groups: acute phase of schizophrenia, acute manic episode of bipolar disorder, methamphetamine-induced psychotic disorder and healthy control subjects. Sample size was 45 in each group. Weekly duration of sun exposure, monthly vitamin D intake and serum levels of vitamin D, calcium, phosphorus, PTH and CRP were assessed. Brief Psychiatric Rating Scale (BPRS) was used to evaluate psychotic symptoms.ResultsDuration of sun exposure and monthly vitamin D intake were comparable among groups. Serum levels of vitamin D, calcium and phosphorus were not statistically different between groups (P = 0.463, P = 0.086 and P = 0.339, respectively). Serum levels of PTH were significantly higher in control group (P < 0.001). CRP levels were significantly lower in control subjects (P < 0.001). The levels of serum vitamin D and CRP did not show statistically significant difference among three groups of patients.ConclusionAcute psychotic disorders seem to be associated with higher CRP and lower PTH levels. Clinical importance of the findings and relation of these differences to the metabolic and inflammatory bases of psychosis are not clear yet.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Elevated serum levels of C-reactive protein are indicative of a poor prognosis in patients with esophageal cancer

Diseases of the Esophagus ◽

10.1111/j.1442-2050.2005.00474.x ◽

2005 ◽

Vol 18 (3) ◽

pp. 146-150 ◽

Cited By ~ 57

Author(s):

P. Guillem ◽

J. P. Triboulet

Keyword(s):

Esophageal Cancer ◽

Poor Prognosis ◽

Elevated Serum ◽

Serum Levels ◽

C Reactive Protein ◽

Reactive Protein

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Sustained Low-Grade Pro-inflammatory State in Unmedicated, Remitted Women with Major Depressive Disorder as Evidenced by Elevated Serum Levels of the Acute Phase Proteins C-reactive Protein and Serum Amyloid A

Biological Psychiatry ◽

10.1016/j.biopsych.2006.09.033 ◽

2007 ◽

Vol 62 (4) ◽

pp. 309-313 ◽

Cited By ~ 71

Author(s):

Mitchel A. Kling ◽

Salvatore Alesci ◽

Gyorgy Csako ◽

Rene Costello ◽

David A. Luckenbaugh ◽

...

Keyword(s):

Serum Amyloid A ◽

Acute Phase Proteins ◽

Elevated Serum ◽

Serum Levels ◽

Low Grade ◽

C Reactive Protein ◽

Major Depressive ◽

Reactive Protein ◽

Amyloid A ◽

Inflammatory State

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Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia

Psychiatry Research ◽

10.1016/j.psychres.2006.07.011 ◽

2007 ◽

Vol 149 (1-3) ◽

pp. 267-271 ◽

Cited By ~ 101

Author(s):

Xiaoduo Fan ◽

Cynthia Pristach ◽

Emily Y. Liu ◽

Oliver Freudenreich ◽

David C. Henderson ◽

...

Keyword(s):

Elevated Serum ◽

Serum Levels ◽

C Reactive Protein ◽

Reactive Protein ◽

Severe Psychopathology

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Does Chronic Low-grade Systemic Inflammation Change Tumor Markers Levels in Patients on Hemodialysis?

Folia Medica ◽

10.3897/folmed.62.e51457 ◽

2020 ◽

Vol 62 (4) ◽

pp. 838-842

Author(s):

Gilmar Pereira Silva ◽

Vítor Pereira Xavier Grangeiro ◽

Carmelita Félix Dantas de Oliveira

Keyword(s):

Tumor Markers ◽

Systemic Inflammation ◽

Elevated Serum ◽

Serum Levels ◽

Hemodialysis Patients ◽

Low Grade ◽

C Reactive Protein ◽

Reactive Protein ◽

Significant Difference ◽

The University

Introduction: End-stage renal disease (ESRD) patients are known to have a high risk of developing cancer-related inflammation. Elevated serum levels of tumor markers in ESRD/hemodialysis patients makes analysis and interpretation difficult.  Aim: To verify the possible relationship between chronic low-grade systemic inflammation serum levels determined by C-reactive protein (CRP) and the tumor biomarkers in patients on hemodialysis.  Materials and methods: A prospective study of prevalence was conducted in the Hemodialysis Sector of the University Hospital of the University of Brasília between July 2016 and December 2016 in men aged 18 to 60 years without clinically detectable cancer. We assessed inflammation by serum high-sensitivity CRP test (hs-CRP) and serum tumor in the case groups and controls. The hemodialysis group was split into two subgroups: group 1: patients with inflammation (CRP > 5 mg/L, n=27), and group 2: patients without inflam-mation (CRP ≤5 mg/L, n=33). Results: There was no significant difference in age mean levels between case groups and controls (44.00±08.00 vs. 41.00±07.00, p=0.08). There was no difference or correlation (p>0.05) between tumor markers levels and patients with and without inflammation.  Conclusions: The results of this study suggest that chronic low-grade systemic inflammation defined by C-reactive protein serum levels does not promote elevated serum PSA levels in chronic hemodialysis patients.

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