A Randomized Trial of Weighted Vest Use in Ambulatory Older Adults: Strength, Performance, and Quality of Life Outcomes

BACKGROUND Deprescribing, a relatively recent concept, has been proposed as a promising solution to the growing issues of polypharmacy and use of medications of questionable benefit among older adults. However, little is known about the health outcomes of deprescribing interventions. OBJECTIVE This study aims to contribute to the knowledge on deprescribing by addressing two specific objectives: 1) describe the impact of deprescribing in adults’ ≥60 years on health outcomes or quality of life; and 2) determine the characteristics of effective interventions in deprescribing. METHODS Primary studies targeting three concepts (older adults, deprescribing, and health/quality of life outcomes) will be included in the review. The search will be performed using key international databases (MEDLINE, EMBASE, CINAHL, Ageline, PsycInfo) and a special effort will be made to identify grey literature. Two reviewers will independently screen the articles, extract the information and evaluate the quality of the selected studies. If methodologically feasible, meta-analyses will be performed for groups of intervention studies reporting on deprescribing interventions for similar medications, used for similar or identical indications and reporting on similar outcomes (for example benzodiazepines used against insomnia and reporting on quality of sleep or quality of life). Alternatively, results will be presented in bottom-line statements (Objectives 1) and a matrix outlining effective interventions (Objective 2). RESULTS The knowledge synthesis may be limited by the availability of high-quality, clinical trials on deprescribing and its outcomes in older adults. Additionally, analyses will likely be affected by studies on the deprescribing of different types of molecules within the same indication, e.g. different pharmacological classes and medications to treat hypertension, and different measures of health and quality of life outcomes for the same indication. CONCLUSIONS Deprescribing becomes more widespread, therefore knowledge on its effects on health are needed. CLINICALTRIAL CRD42015020866

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Implant supported dental rehabilitation following segmental mandibular reconstruction- quality of life outcomes of a prospective randomized trial

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2016.04.013 ◽

2016 ◽

Vol 44 (7) ◽

pp. 800-810 ◽

Cited By ~ 22

Author(s):

Vinay V. Kumar ◽

P.C. Jacob ◽

Supriya Ebenezer ◽

Moni A. Kuriakose ◽

Vikram Kekatpure ◽

...

Keyword(s):

Quality Of Life ◽

Randomized Trial ◽

Mandibular Reconstruction ◽

Prospective Randomized Trial ◽

Life Outcomes ◽

Quality Of Life Outcomes ◽

Reconstruction Quality ◽

Dental Rehabilitation

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Quality of Life Outcomes After Stereotactic Ablative Radiation Therapy (SABR) Versus Standard of Care Treatments in the Oligometastatic Setting: A Secondary Analysis of the SABR-COMET Randomized Trial

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2019.08.041 ◽

2019 ◽

Vol 105 (5) ◽

pp. 943-947 ◽

Cited By ~ 7

Author(s):

Robert Olson ◽

Suresh Senan ◽

Stephen Harrow ◽

Stewart Gaede ◽

Alexander Louie ◽

...

Keyword(s):

Quality Of Life ◽

Radiation Therapy ◽

Randomized Trial ◽

Secondary Analysis ◽

Standard Of Care ◽

Life Outcomes ◽

Quality Of Life Outcomes ◽

Stereotactic Ablative Radiation Therapy

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Enhancing Older Adults’ Well-Being and Quality of Life through Purposeful Activity: A Systematic Review of Intervention Studies

The Gerontologist ◽

10.1093/geront/gnab017 ◽

2021 ◽

Author(s):

Rebecca Owen ◽

Katherine Berry ◽

Laura J E Brown

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Functional Role ◽

Social Roles ◽

Well Being ◽

Life Outcomes ◽

Quality Of Life Outcomes ◽

Health And Social Care ◽

Purposeful Activity

Abstract Background and Objectives Population aging represents a significant challenge for health and social care services. Older adults who engage in activities that offer a sense of purpose have significantly better physical and psychological health outcomes. However, age-related functional limitations and losses of social roles can present barriers to engaging in purposeful activity, especially for those older adults within the ‘oldest old’ age range (i.e. 80 years and over). This review aimed to determine the nature and effectiveness of purposeful activity interventions in older adults, aged ≥80 years, with respect to well-being and quality of life outcomes. Research Design and Methods Three databases were searched from their inception to April 2020. The search yielded 8,916 records, which resulted in eight eligible studies. Results The interventions were divided into two groups: (1) interventions that gave participants a specific functional role, such as volunteer or mentor (n=5); (2) interventions that supported participants to develop a new skill (n=3). The quality of the evidence was variable. The strongest evidence was for interventions that assigned a functional role, which appeared to be somewhat effective in improving well-being outcomes. Discussion and Implications There is preliminary evidence that purposeful activity interventions, particularly those that involved taking on a functional role, can improve well-being and quality of life outcomes in older adults aged 80 years and over. These findings have implications for professionals and carers to support older adults to access more purposeful social roles and create opportunities for helping and reciprocation.

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