Effect of periodontal treatment on IL-1β, IL-1ra, and IL-10 levels in gingival crevicular fluid in patients with aggressive periodontitis

Aim. The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods. Twenty-six generalized aggressive periodontitis patients were treated with three different methods (SRP, SRP+diode laser, and SRP+Er,Cr:YSGG laser) applied to three different half-jaws in the same patients. Pre- and posttreatment clinical periodontal parameters and GCF IL-1β and IL-37 levels were measured. Results. There was a statistically significant decrease (p<0.05) between pretreatment and posttreatment clinical periodontal parameters and IL-1β and IL-37 levels. When the reduction rates of IL-37 and IL-1β levels after treatment were evaluated, the decrease in IL-37 and IL-1β levels after treatment was lowest in the SRP group and highest in the SRP+Er,Cr:YSGG group. In addition, the amount of decrease in IL-1β in SRP+diode and SRP+Er,Cr:YSGG groups was found to be higher than that in IL-37. Furthermore, there was a positive correlation between IL-37 and IL-1β in all groups (p<0.01). Conclusion. Er,Cr:YSGG laser is more effective than diode laser for the treatment of aggressive periodontitis. IL-37 and IL-1β are cytokines that function together and thus must be evaluated together.

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Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis

Journal of Periodontal Research ◽

10.1111/jre.12137 ◽

2013 ◽

Vol 49 (5) ◽

pp. 574-583 ◽

Cited By ~ 16

Author(s):

R. Lu ◽

H. Meng ◽

X. Gao ◽

L. Xu ◽

X. Feng

Keyword(s):

Fatty Acid ◽

Short Chain Fatty Acid ◽

Gingival Crevicular Fluid ◽

Aggressive Periodontitis ◽

Chain Fatty Acid ◽

Periodontal Treatment ◽

Short Chain ◽

Crevicular Fluid

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Effects of smoking on the gingival crevicular fluid levels of interleukin‐17A, interleukin‐17E, and oxidative stress following periodontal treatment process

Journal of Periodontal Research ◽

10.1111/jre.12831 ◽

2021 ◽

Author(s):

Muge Lütfioğlu ◽

Umur Sakallıoğlu ◽

Eser Elif Sakallıoğlu ◽

Feyza O. Özden ◽

Sebati Sinan Ürkmez ◽

...

Keyword(s):

Oxidative Stress ◽

Treatment Process ◽

Gingival Crevicular Fluid ◽

Periodontal Treatment ◽

Interleukin 17A ◽

Crevicular Fluid ◽

Fluid Levels ◽

And Oxidative Stress

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Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

BioMed Research International ◽

10.1155/2014/420830 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Oya Türkoğlu ◽

Elif Azarsız ◽

Gülnur Emingil ◽

Necil Kütükçüler ◽

Gül Atilla

Keyword(s):

Gingival Crevicular Fluid ◽

Periodontal Diseases ◽

Study Groups ◽

Aggressive Periodontitis ◽

Control Group ◽

Proteinase 3 ◽

Cathepsin C ◽

Probing Depth ◽

Inflammatory Processes ◽

Crevicular Fluid

Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases.Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA.Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting ageP<0.05. No differences were found in GCF cathepsin C levels among the study groupsP>0.05. Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amountsP<0.01but not with cathepsin C total amountsP>0.05.Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.

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