scholarly journals Effect of nonsurgical periodontal treatment in conjunction with either systemic administration of amoxicillin and metronidazole or additional photodynamic therapy on the concentration of matrix metalloproteinases 8 and 9 in gingival crevicular fluid in patients with aggressive periodontitis

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Anna Skurska ◽  
Ewa Dolinska ◽  
Małgorzata Pietruska ◽  
Jan K. Pietruski ◽  
Violetta Dymicka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Matrix Metalloproteinases ◽  
Gingival Crevicular Fluid ◽  
Aggressive Periodontitis ◽  
Systemic Administration ◽  
Periodontal Treatment ◽  
Crevicular Fluid

Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment

2017 ◽  
Vol 22 (2) ◽  
pp. 1083-1092 ◽  
Author(s):  
Federica Romano ◽  
Loretta Bongiovanni ◽  
Laura Bianco ◽  
Federica Di Scipio ◽  
Zhiqian Yang ◽  
...  
Keyword(s):  
Gingival Crevicular Fluid ◽  
Aggressive Periodontitis ◽  
Periodontal Treatment ◽  
Crevicular Fluid

scholarly journals Effects of Er,Cr:YSGG and Diode Lasers on Clinical Parameters and Gingival Crevicular Fluid IL-1β and IL-37 Levels in Generalized Aggressive Periodontitis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Ahmet Cemil Talmac ◽  
Metin Calisir ◽  
Emre Gurkan Eroglu ◽  
Abdullah Seckin Ertugrul
Keyword(s):  
Diode Laser ◽  
Gingival Crevicular Fluid ◽  
Diode Lasers ◽  
Aggressive Periodontitis ◽  
Periodontal Treatment ◽  
Clinical Parameters ◽  
Positive Correlation ◽  
Cytokine Levels ◽  
Before And After ◽  
Crevicular Fluid

Aim. The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods. Twenty-six generalized aggressive periodontitis patients were treated with three different methods (SRP, SRP+diode laser, and SRP+Er,Cr:YSGG laser) applied to three different half-jaws in the same patients. Pre- and posttreatment clinical periodontal parameters and GCF IL-1β and IL-37 levels were measured. Results. There was a statistically significant decrease (p<0.05) between pretreatment and posttreatment clinical periodontal parameters and IL-1β and IL-37 levels. When the reduction rates of IL-37 and IL-1β levels after treatment were evaluated, the decrease in IL-37 and IL-1β levels after treatment was lowest in the SRP group and highest in the SRP+Er,Cr:YSGG group. In addition, the amount of decrease in IL-1β in SRP+diode and SRP+Er,Cr:YSGG groups was found to be higher than that in IL-37. Furthermore, there was a positive correlation between IL-37 and IL-1β in all groups (p<0.01). Conclusion. Er,Cr:YSGG laser is more effective than diode laser for the treatment of aggressive periodontitis. IL-37 and IL-1β are cytokines that function together and thus must be evaluated together.

scholarly journals Clinical and Biological Effects of Adjunctive Photodynamic Therapy in Refractory Periodontitis

2019 ◽  
Vol 10 (2) ◽  
pp. 139-145
Author(s):  
Rola Al Habashneh ◽  
Mohammad A Mashal ◽  
Yousef Khader ◽  
Rana Qudah
Keyword(s):  
Photodynamic Therapy ◽  
Gingival Crevicular Fluid ◽  
Biological Effects ◽  
Gingival Recession ◽  
Periodontal Treatment ◽  
Control Group ◽  
Clinical Parameters ◽  
Biological Parameters ◽  
Probing Depth ◽  
Crevicular Fluid

Introduction: To date, no novel treatment approach is available for optimum outcomes regarding refractory periodontitis. The aim of the present study was to assess the efficiency of photodynamic therapy (PDT) in treating patients diagnosed with refractory periodontitis and compare the clinical and biological outcomes of conventional periodontal treatment with or without adjunctive PDT in these patients, by assessing clinical parameters (plaque index [PI], gingival recession [GR], bleeding on probing [BOP], periodontal probing depth [PPD] and clinical attachment level [CAL]) as well as biological parameters (IL-1β) in the gingival crevicular fluid (GCF). Methods: Sixteen patients within the age of 30 to 60 years, with a mean age of 40 years old, diagnosed with refractory periodontitis were included. In this split mouth design study, 2 quads (1 upper + 1 lower) from the same patient were randomly treated with (scaling and root planing [SRP]+PDT) together. The other 2 quadrants (1 upper + 1 lower) were treated by SRP only and selected to serve as controls. Clinical parameters including PI, GR, BOP, PPD and CAL and biological parameters (IL-1β) in the GCF were measured at baseline, then at, 2 and 6 months after therapy. Results: A statistically significant reduction in several clinical parameters as, BOP (P < 0.001), PI (P < 0.001), PPD (P < 0.001) and CAL (P < 0.001) in quadrant treated with SRP and adjunctive PDT when compared to control group treated with SRP alone was observed and both therapies showed non-statistically significant differences in the reduction of IL-1β level. Conclusion: The inclusion of PDT as an adjunctive measure to nonsurgical conventional periodontal treatment seems to be a useful therapeutic measure in refractory periodontitis treatment.

Antimicrobial Photodynamic Therapy in the Non-Surgical Treatment of Aggressive Periodontitis: Cytokine Profile in Gingival Crevicular Fluid, Preliminary Results

2009 ◽  
Vol 80 (1) ◽  
pp. 98-105 ◽  
Author(s):  
Rafael Ramos de Oliveira ◽  
Humberto Oswaldo Schwartz-Filho ◽  
Arthur Belém Novaes ◽  
Gustavo Pompermaier Garlet ◽  
Raphael Freitas de Souza ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Treatment ◽  
Gingival Crevicular Fluid ◽  
Aggressive Periodontitis ◽  
Cytokine Profile ◽  
Antimicrobial Photodynamic Therapy ◽  
Preliminary Results ◽  
Crevicular Fluid ◽  
Non Surgical Treatment

scholarly journals Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Oya Türkoğlu ◽  
Elif Azarsız ◽  
Gülnur Emingil ◽  
Necil Kütükçüler ◽  
Gül Atilla
Keyword(s):  
Gingival Crevicular Fluid ◽  
Periodontal Diseases ◽  
Study Groups ◽  
Aggressive Periodontitis ◽  
Control Group ◽  
Proteinase 3 ◽  
Cathepsin C ◽  
Probing Depth ◽  
Inflammatory Processes ◽  
Crevicular Fluid

Aim. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases.Design. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA.Results. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting ageP<0.05. No differences were found in GCF cathepsin C levels among the study groupsP>0.05. Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amountsP<0.01but not with cathepsin C total amountsP>0.05.Conclusions. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.

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