Experimental basis of standardized specimen collection: The effect of the site of venipuncture on the blood picture, the white blood cell differential count, and the serum albumin concentration

We measured hematocrit and serum albumin concentration at birth and red blood cell and plasma volume soon after birth in prematurely born infants with erythroblastosis fetalis of varying severity and examined the realtionships between these variables and the presence and severity of hydrops fetalis. Blood volumes in most of these infants were similar to the established normals for newborn infants without erythroblastosis. There was no simple association between blood volume and the presence of hydrops. Nonhydropic and severely hydropic infants had, on the average, similar and normal blood volumes, while mildly hydropic infants had low blood volumes. Anemia correlated fairly well with severity of hydrops but almost a quarter of the infants with severe hydrops were only mildly anemic. Red blood cell volume decreased and plasma volume increased proportionally with the degree of anemia at birth. Thus, hydropic infants with severe anemia had large plasma volumes while those with milder anemia did not. On the other hand, hypoalbuminemia was common and correlated closely with severity of hydrops. We suggest that hydrops results at least in part from low plasma colloid osmotic pressure due to hypoalbuminemia.

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Serum Albumin Concentration and Cognitive Impairment

Current Alzheimer Research ◽

10.2174/1872209197471563128 ◽

2009 ◽

Vol 999 (999) ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

David J. Llewellyn

Keyword(s):

Cognitive Impairment ◽

Serum Albumin ◽

Albumin Concentration ◽

Serum Albumin Concentration

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Low serum albumin concentration is associated with increased risk of osteoporosis in postmenopausal patients with rheumatoid arthritis

Journal of Orthopaedic Science ◽

10.1016/j.jos.2021.08.018 ◽

2021 ◽

Author(s):

Yoshio Nagayama ◽

Kosuke Ebina ◽

Hideki Tsuboi ◽

Makoto Hirao ◽

Jun Hashimoto ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Serum Albumin ◽

Albumin Concentration ◽

Serum Albumin Concentration ◽

Increased Risk ◽

Low Serum

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Serum Albumin and Future Risk of Hip, Humeral, and Wrist Fractures in Caucasian Men: New Findings from a Prospective Cohort Study

Medical Principles and Practice ◽

10.1159/000499738 ◽

2019 ◽

Vol 28 (5) ◽

pp. 401-409 ◽

Cited By ~ 2

Author(s):

Setor K. Kunutsor ◽

Ari Voutilainen ◽

Michael R. Whitehouse ◽

Samuel Seidu ◽

Jussi Kauhanen ◽

...

Keyword(s):

Serum Albumin ◽

Area Under The Curve ◽

Fracture Prevention ◽

Albumin Concentration ◽

Serum Albumin Concentration ◽

Baseline Serum ◽

Increased Risk ◽

New Findings ◽

Caucasian Men ◽

Low Serum

Objective: Low serum albumin concentration is associated with poor health outcomes, but its relationship with the risk of fractures has not been reliably quantified. We aimed to assess the prospective association of serum albumin with the risk of fractures in a general population. Subjects and Methods: Baseline serum albumin concentrations were measured in 2,245 men aged 42–61 years in the Kuopio Ischemic Heart Disease study. Hazard ratios (HRs) (95% confidence intervals) were calculated for incident fractures. Results: A total of 121 fractures (hip, humeral, or wrist) were recorded during a median follow-up of 25.6 years. The risk of fractures increased linearly below a serum albumin concentration of ∼48 g/L. The age-adjusted HR (95% CI) for fractures per 1 standard deviation lower serum albumin was 1.24 (1.05–1.48). On further adjustment for several conventional and emerging risk factors, the HR was attenuated to 1.21 (1.01–1.45). Comparing the bottom versus top quartile of serum albumin levels, the corresponding adjusted HRs were 2.48 (1.37–4.48) and 2.26 (1.23–4.14). The association of serum albumin with fracture risk did not differ substantially according to age, body mass index, blood pressure, physical activity, alcohol consumption, socioeconomic status, inflammation, prevalent diseases, and smoking. Serum albumin at a threshold of 41.5 g/L demonstrated an area under the curve of 0.5850. Conclusion: In middle-aged Caucasian men, low serum albumin is associated with an increased risk of future fractures. The potential relevance of serum albumin concentrations in fracture prevention and prediction deserves further evaluation.

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