scholarly journals Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Maryam Mardani ◽  
Hossein Mofidi ◽  
Ladan Dastgheib ◽  
Sara Ranjbar ◽  
Nasrin Hamidizadeh
Keyword(s):  
Lichen Planus ◽  
Crucial Role ◽  
Oral Lichen Planus ◽  
Elevated Serum ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Healthy Controls ◽  
Cytokine Network ◽  
Interleukin 23 ◽  
Oral Lichen

Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. Method. The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann–Whitney test. Results. IL-23 levels in the patient serum with oral lichen planus ( P value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls ( P value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus ( P value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. Conclusions. Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

2018 ◽  
Author(s):  
Hamid Reza Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Background and Aim: Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Materials and Methods: Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the NOS questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Results: Out of 70 studies found in the databases, eight studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of  IgA, IgG, and IgM were -0.13 g/L [95%CI: -0.24, -0.02; P = 0.02], 1.01 g/L [95%CI: -0.91, 2.93; P = 0.30], and -0.06 g/L [95%CI: -0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95%CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95%CI: -0.20, 1.38; P = 0.14], respectively. Conclusions: Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had a higher diagnostic value than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

scholarly journals Serum and Salivary IgA, IgG, and IgM Levels in Oral Lichen Planus: A Systematic Review and Meta-Analysis of Case-Control Studies

Medicina ◽  
2018 ◽  
Vol 54 (6) ◽  
pp. 99 ◽  
Author(s):  
Hamid Mozaffari ◽  
Elisa Zavattaro ◽  
Abas Abdolahnejad ◽  
Pia Lopez-Jornet ◽  
Neda Omidpanah ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Inflammatory Factors ◽  
Cochrane Library ◽  
Healthy Controls ◽  
Case Control Studies ◽  
Salivary Iga ◽  
Oral Lichen

Immunoglobulins (IgA, IgG, and IgM) are significant anti-inflammatory factors. The meta-analysis aimed to assess the serum and salivary levels of Igs as more important immunoglobulins in patients affected by oral lichen planus (OLP) compared to the healthy controls. Four databases, including PubMed/Medline, Scopus, Web of Science, and Cochrane Library as well as Iranian databases were checked up to January 2018 without language restriction. The quality of each involved study was done using the Newcastle–Ottawa Quality Assessment Scale (NOS) questionnaire. A random-effects model analysis was done by RevMan 5.3 software applying the mean difference (MD) plus 95% confidence intervals (CIs). The CMA 2.0 software was applied to calculate the publication bias among the studies. Out of 70 studies found in the databases, 8 studies were involved and analyzed in the meta-analysis. The meta-analysis included 282 OLP patients and 221 healthy controls. The pooled MDs of serum levels of IgA, IgG, and IgM were −0.13 g/L [95% CI: −0.24, −0.02; P = 0.02], 1.01 g/L [95% CI: −0.91, 2.93; P = 0.30], and −0.06 g/L [95% CI: −0.25, 0.14; P = 0.56], respectively; whereas, the salivary IgA and IgG levels were 71.54 mg/L [95% CI: 12.01, 131.07; P = 0.02] and 0.59 mg/L [95% CI: −0.20, 1.38; P = 0.14], respectively. Considering the few studies performed on saliva, the results suggested that the salivary levels, especially IgA level had higher values than the serum levels. Therefore, the salivary immunoglobulins can play a significant function in the OLP pathogenesis.

Elevated serum levels of the apoptosis related molecules TNF-alpha, Fas/Apo-1 and Bcl-2 in oral lichen planus

2004 ◽  
Vol 33 (7) ◽  
pp. 386-390 ◽  
Author(s):  
A. Sklavounou-Andrikopoulou ◽  
E. Chrysomali ◽  
M. Iakovou ◽  
G. A. Garinis ◽  
A. Karameris
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Elevated Serum ◽  
Serum Levels ◽  
Tnf Alpha ◽  
Oral Lichen

Interleukin-10 in Oral Lichen Planus – Review and Meta-Analysis

2020 ◽  
Vol 16 (1) ◽  
pp. 37-43
Author(s):  
Farzaneh Agha-Hosseini ◽  
Nima Rezaei ◽  
Mahdieh-Sadat Moosavi
Keyword(s):  
Autoimmune Diseases ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Chronic Inflammatory Disease ◽  
Over Expression ◽  
Significant Difference ◽  
Oral Lichen

Background: Interleukin 10 (IL-10) is a powerful anti-inflammatory cytokine capable of preventing inflammatory and autoimmune diseases. Oral lichen planus (OLP) is an autoimmune, chronic, inflammatory disease with relapsing nature involving oral mucous membranes. It was prevsiouly assumed that like other autoimmune diseases, IL-10 may have a role in OLP pathogenesis, and many studies focused on that. But there are obvious controversies among IL-10 levels in OLP patients. Objective: In this review with Meta-Analysis, we attempt to assess IL-10 expression in OLP patients. Methods: The search was conducted via Pubmed, Ovid, and Google Scholar, to identify articles published up to Jun 2020. A meta-Analysis by Revman 5.3 was conducted based on serum levels of IL-10 in 313 OLPs and 203 controls. Results: With Meta-Analysis in 313 OLPs and 203 controls, the Mean difference between IL-10 in OLPs and controls was obtained as 0.26 (95% CI: -0.51-1.03), demonstrating no statistically significant difference. Conclusion: IL-10, in concert with its receptors, has a crucial role in the pathogenesis of various diseases, including inflammatory, infectious, and autoimmune diseases. Both over-expression, as well as IL-10 deficiency, have been described in oral lichen planus. With Meta-Analysis on serum IL-10 levels, it is speculated that no significant relationship exists between IL-10 and OLP pathogenesis. With respect to the importance of cytokines in the autoimmunity process, performing additional studies is of necessity to understand the association of other cytokines with OLP predisposition and its underlying pathological processes.

Evaluation of the serum levels of galectin-3 in patients with oral lichen planus disease

Oral Diseases ◽  
2019 ◽  
Vol 25 (2) ◽  
pp. 466-470 ◽  
Author(s):  
Janan Ghapanchi ◽  
Azadeh Andisheh-Tadbir ◽  
Pooriya Torkaman ◽  
Mahyar Malekzadeh ◽  
Maryam Mardani
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Serum Levels ◽  
Galectin 3 ◽  
Oral Lichen

scholarly journals Role of apoptosis in erosive and reticular oral lichen planus exhibiting variable epithelial thickness

2008 ◽  
Vol 19 (3) ◽  
pp. 179-185 ◽  
Author(s):  
Juliana M. Caldeira Brant ◽  
Anilton C. Vasconcelos ◽  
Luciana V. Rodrigues
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Mechanical Trauma ◽  
Epithelial Thickness ◽  
Healthy Mucosa ◽  
Toxic Agents ◽  
Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease with different clinical types. Reticular and erosive forms are the most common. Although the cause of OLP remains speculative, many findings suggest auto-immune involvement, mediated by T lymphocytes against the basal keratinocytes. Inflammation, mechanical trauma or toxic agents can affect the epithelial homeostasia. Increased apoptosis may cause a decrease in epithelial thickness reflecting in the activity of the lesion. The objective of this study was to evaluate the occurrence of apoptosis and epithelial thickness in reticular and erosive forms of OLP. 15 samples of OLP each type (reticular and erosive) plus 10 of healthy mucosa were collected and processed. After morphometry, the apoptotic index and epitelial thickness were obtained. TUNEL and M30 CytoDEATH immunohistochemical assay were used to validate the morphologic criteria used. Apoptosis in the erosive OLP was significantly more intense than in the reticular type and both forms of OLP presented more apoptosis than the healthy oral mucosa. Healthy oral mucosa was thicker than both OLP forms and thicker in OLP reticular form than in the erosive one. The clinical differences between reticular and erosive forms of OLP are related to variations in epithelial thickness and in intensity of apoptosis.

scholarly journals Salivary Cortisol Levels in Patients with Oral Lichen Planus—A Pilot Case-Control Study

2019 ◽  
Vol 7 (2) ◽  
pp. 59 ◽  
Author(s):  
Ivana Skrinjar ◽  
Valentina Vidranski ◽  
Bozana Loncar Brzak ◽  
Danica Vidovic Juras ◽  
Ana Andabak Rogulj ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Salivary Cortisol ◽  
Oral Lichen Planus ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Unstimulated Saliva ◽  
Cortisol Levels ◽  
Oral Lichen ◽  
Control Study

It is known that cortisol level increases in stress situations. The aim of the study was to measure the levels of salivary cortisol in patients with oral lichen planus (OLP) and healthy controls. This was a case-control pilot study which included seven patients with reticular (non-symptomatic) OLP, eight patients with atrophic/erosive (symptomatic) OLP, and nine healthy controls. We hypothesized that patients with an atrophic/erosive type of OLP have higher levels of cortisol compared to patients with the reticular type of OLP and healthy controls. In each participant, unstimulated saliva was collected in order to determine cortisol levels by using commercially available ELISA kit. Our results have shown no differences between levels of salivary cortisol in OLP patients and healthy controls. We can conclude that further research with a larger number of OLP patients is needed to determine the correlation between OLP and stress.

scholarly journals Overexpression and Selectively Regulatory Roles of IL-23/IL-17 Axis in the Lesions of Oral Lichen Planus

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Rui Lu ◽  
Xin Zeng ◽  
Qi Han ◽  
Mu Lin ◽  
Long Long ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Immune Disorders ◽  
Oral Keratinocytes ◽  
Regulatory Pathway ◽  
Normal Oral Mucosa ◽  
Oral Lichen

Interleukin- (IL-) 23/IL-17 axis is a newly discovered proinflammatory signaling pathway and has been implicated in the pathogenesis of many chronic inflammatory and immune disorders. Here we investigated whether the IL-23/IL-17 axis was present and functional in the lesions of oral lichen planus (OLP), a chronic inflammatory disease affecting the oral mucosa. Using immunohistochemistry and quantitative PCR, we found that the subunits of IL-23 and IL-17 were overexpressed in OLP lesions than in normal oral mucosa tissues. In addition, the expressions of IL-23 and IL-17 are positively correlated in reticular OLP tissues. Results from in vitro studies revealed that exogenous IL-23 could increase the percentage of Th17 cells and IL-17 production in the CD4+T cells from reticular OLP patients. Furthermore, we also found that exogenous IL-17 could significantly enhance the mRNA expressions ofβ-defensin-2, -3, CCL-20, IL-8, and TNF-α, but notβ-defensin-1, CXCL-9, -10, -11, CCL-5, and IL-6 in human oral keratinocytes. Taken together, our results revealed an overexpression pattern and selectively regulatory roles of IL-23/IL-17 axis in the OLP lesions, suggesting that it may be a pivotal regulatory pathway in the complex immune network of OLP lesions.

scholarly journals The treatment of the lysozyme-containing drugs of patients with oral lichen planus together with dental pathology

2016 ◽  
Author(s):  
O. V. Yeliseyeva
Keyword(s):  
Lipid Peroxidation ◽  
Lichen Planus ◽  
Oral Mucosa ◽  
Oral Lichen Planus ◽  
Alveolar Bone ◽  
Chronic Inflammatory Disease ◽  
Pathogenic Agent ◽  
Dental Pathology ◽  
The Common ◽  
Oral Lichen

Prevalence and severity of generalized parodontitis depend especially on the course of diseases affecting theoral mucosa and those ones which are characterized by involvement of the oral mucosa. These diseases include mainly lichen planus. The common pathogenic agent of generalized parodontitis and lichen planus as well as of combination of them is inflammation, as generalized parodontitis is inflammation of parardontium tissue characterized by destruction of periodontium and dental ligamentous apparatus of the alveolar bone and lichen planus is a chronic inflammatory disease of skin and oral mucosa. The purpose is to study processes of lipid peroxidation in the saliva of patients with lichen planus of the skin along with chronic generalized parodontitis.

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